Cited by 74Estrogen and related hormone effectsProtein Tyrosine PhosphatasesBreast Cancer Treatment Studies

DUSP22/LMW-DSP2 regulates estrogen receptor-α-mediated signaling through dephosphorylation of Ser-118

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Sekine, Y, Ikeda, O, Hayakawa, Y, Tsuji, S, Imoto, S, Aoki, N, Sugiyama, K, Matsuda, T·2007·Oncogene

Abstract

In the previous study, we demonstrated the involvement of dual specificity phosphatase 22 (DUSP22/LMW-DSP2) in regulating the leukemia inhibitory factor/interleukin-6/signal transducer and activator of transcription 3-mediated signaling pathway. In this study, we show beta-estradiol (E2)-induced DUSP22 mRNA expression in estrogen receptor alpha (ERalpha)-positive breast cancer cells, whereas E2-induced phosphorylation and activation of ERalpha was suppressed by overexpression of DUSP22 but not catalytically inactive mutants. Furthermore, small-interfering RNA-mediated reduction of DUSP22 expression enhanced ERalpha-mediated transcription and endogenous gene expression. In fact, DUSP22 associated with ERalpha in vivo and both endogenous proteins interacted in ERalpha-positive breast cancer T47D cells. These results strongly suggest that DUSP22 acts as a negative regulator of the ERalpha-mediated signaling pathway.

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  • MGMT, DUSP22, CDCA2, ID2, TNFRSF1B, ZNF681, and IGSF21 may have a role in the etiology and pathogenesis of endometriosis.

    “The MGMT, DUSP22, CDCA2, ID2, TNFRSF1B, ZNF681, and IGSF21 may have a role in the etiology and pathogenesis of this disease.[31][32][33][34][35][36][37][38][39][40]”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [33]

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Authors
Sekine, Y., Ikeda, O., Hayakawa, Y., Tsuji, S., Imoto, S., Aoki, N., Sugiyama, K., & Matsuda, T.
Affiliations
  • Hokkaido University (JP)
  • Mie University (JP)
  • Boehringer Ingelheim (Japan) (JP)
Corresponding author
Matsuda, T
Venue
Oncogene
Published
2007-03-26
Volume
26
Issue
41
Pages
6038-6049
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
OpenAlex
W2019924027
Cited by
74
References
43
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 9 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 1
FWCI
3.75
Type
journal article
Language
en
Open access
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
DUSP22, estrogen receptor alpha, beta-estradiol, ERα phosphorylation, ERα-positive breast cancer, negative transcriptional regulation, protein-protein interaction, T47D cells
MeSH terms
Breast Neoplasms, Estradiol, Female, HeLa Cells, Humans, Phosphoprotein Phosphatases, Phosphoserine, RNA, Messenger, Tumor Cells, Cultured, Signal Transduction, Transcriptional Activation, Polymerase Chain Reaction, Protein Tyrosine Phosphatases, Estrogen Receptor alpha, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases

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