The DOI matches its Crossref record; 142 of the 143 references it cites were found in a registry or an index.
Hox genes in hematopoiesis and leukemogenesis
Abstract
Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily at the level of hematopoietic stem cell function. A large body of evidence now links Hox genes to leukemic transformation including dysregulated HOX expression in leukemic patient samples, their involvement as oncogenic fusion proteins with NUP98 and their requirement for the oncogenicity of Mll fusions. In recent years, much attention has been devoted to the identification and characterization of leukemic stem cells. Given the documented role of Hox genes in hematopoiesis and leukemogenesis, we propose that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells.
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“The homeobox protein HOXA9 contributes to haematopoiesis and is frequently overexpressed in human AMLs,8 notably in patients harbouring the IDH1R132H mutation.9”
From Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia (2018) · cites this paper as [8]
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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
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The Hox genes and their roles in oncogenesis
Shah, N., & Sukumar, S. V. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2826 · Cited by 845
Buenrostro, J. D., Corces, M. R., Lareau, C. A., Wu, B., Schep, A. N., Aryee, M. J., Majeti, R., Chang, H. Y., & Greenleaf, W. J. (2018) · Cell · doi:10.1016/j.cell.2018.03.074 · Cited by 670
Metadata
- Authors
- Argiropoulos, B., & Humphries, R. K.
- Affiliations
- BC Cancer Agency (CA)
- Corresponding author
- Humphries, R K
- Venue
- Oncogene
- Published
- 2007-10-15
- Volume
- 26
- Issue
- 47
- Pages
- 6766-6776
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1976021347
- Cited by
- 492
- References
- 143
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 22 · 2018: 20 · 2017: 28 · 2016: 28 · 2015: 27 · 2014: 38 · 2013: 43 · 2012: 38
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Keywords
- Hox genes, hematopoiesis, leukemogenesis, hematopoietic stem cells, leukemia stem cells, MLL fusion, self-renewal, bone marrow transplantation, fusion oncogenes
- MeSH terms
- Animals, Genes, Homeobox, Hematopoiesis, Humans, Leukemia, Homeodomain Proteins
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