Cited by 498Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research

The DOI matches its Crossref record; 142 of the 143 references it cites were found in a registry or an index.

Hox genes in hematopoiesis and leukemogenesis

Argiropoulos, B, Humphries, R K·2007·Oncogene

Open this paper in CoChat — free account

Abstract

Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily at the level of hematopoietic stem cell function. A large body of evidence now links Hox genes to leukemic transformation including dysregulated HOX expression in leukemic patient samples, their involvement as oncogenic fusion proteins with NUP98 and their requirement for the oncogenicity of Mll fusions. In recent years, much attention has been devoted to the identification and characterization of leukemic stem cells. Given the documented role of Hox genes in hematopoiesis and leukemogenesis, we propose that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells.

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1210760

Cites

142 of 142 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516
Identification of human brain tumour initiating cells
Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,564
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
O'Brien, C. A., Pollett, A. F., Gallinger, S., & Dick, J. E. (2006) · Nature · doi:10.1038/nature05372 · Cited by 4,174
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Hox genes in vertebrate development
Krumlauf, R. K. (1994) · Cell · doi:10.1016/0092-8674(94)90290-9 · Cited by 2,079
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
Yeoh, A. E. J., Ross, M. E., Shurtleff, S. A., Williams, W. K., Patel, D. H., Mahfouz, R. A., Behm, F. G., Raimondi, S. C., Relling, M. V., Patel, A. R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00032-6 · Cited by 1,914
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties
Ponti, D., Costa, A., Zaffaroni, N., Pratesi, G., Petrangolini, G., Coradini, D., Pilotti, S., Pierotti, M. A., & Daidone, M. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0626 · Cited by 1,725
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
Armstrong, S. A., Staunton, J. E., Silverman, L. B., Pieters, R., den Boer, M. L., Minden, M. D., Sallan, S. E., Lander, E. S., Golub, T. R., & Korsmeyer, S. J. (2001) · Nature Genetics · doi:10.1038/ng765 · Cited by 1,721
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Krivtsov, A. V., Twomey, D., Feng, Z., Stubbs, M. C., Wang, Y., Faber, J., Levine, J. E., Wang, J., Hahn, W. C., Gilliland, D. G., et al. (2006) · Nature · doi:10.1038/nature04980 · Cited by 1,513 · cited 3×
“Support for this hypothesis comes from multiple murine studies demonstrating that purified committed hematopoietic progenitors, with limited self-renewal capacities, engineered to overexpress the Hox gene regulators MLL-AF9 (Krivtsov et al., 2006), MLL-ENL (Cozzio et al.”
Background
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Genome Regulation by Polycomb and Trithorax Proteins
Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,418
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
Hope, K. J., Jin, L., & Dick, J. E. (2004) · Nature Immunology · doi:10.1038/ni1080 · Cited by 986
HOMEODOMAIN PROTEINS
Gehring, W. J., Affolter, M., & Bürglin, T. R. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002415 · Cited by 861
Characterization of clonogenic multiple myeloma cells
Matsui, W. H., Huff, C. A., Wang, Q., Malehorn, M., Barber, J. P., Tanhehco, Y. C., Smith, B. D., Civin, C. I., & Jones, R. J. (2003) · Blood · doi:10.1182/blood-2003-09-3064 · Cited by 794
Hematopoietic Stem Cells
Bryder, D., Rossi, D. J., & Weissman, I. L. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060312 · Cited by 764
HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700
Self-citation
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
Huntly, B. J. P., Shigematsu, H., Deguchi, K., Lee, B. H., Mizuno, S., Duclos, N., Rowan, R., Amaral, S., Curley, D., Williams, I. R., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.015 · Cited by 697
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
Bhardwaj, G., Murdoch, B., Wu, D., Baker, D. P., Williams, K. P., Chadwick, K., Ling, L. E., Karanu, F., & Bhatia, M. (2001) · Nature Immunology · doi:10.1038/84282 · Cited by 676
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitorsPreprint
Cozzio, A., Passegue, E. A., Ayton, P. M., Karsunky, H., Cleary, M. L., & Weissman, I. L. (2003) · Genes & Development · doi:10.1101/gad.1143403 · Cited by 656
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
Varnum‐Finney, B., Xu, L., Brashem‐Stein, C., Nourigat, C., Flowers, D. A., Bakkour, S., Pear, W. S., & Bernstein, I. D. (2000) · Nature Medicine · doi:10.1038/81390 · Cited by 642
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
Kroon, E., Krosl, J., Thorsteinsdottir, U., Baban, S., Buchberg, A. M., & Sauvageau, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3714 · Cited by 640
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.Preprint
Sauvageau, G., Þorsteinsdóttir, U., Eaves, C. J., Lawrence, H. J., Largman, C., Lansdorp, P. M., & Humphries, R. K. (1995) · Genes & Development · doi:10.1101/gad.9.14.1753 · Cited by 586
Self-citation
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
Somervaille, T. C. P., & Cleary, M. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.020 · Cited by 582
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515
Hox cofactors in vertebrate development
Moens, C. B., & Selleri, L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.032 · Cited by 515
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.
Sauvageau, G., Lansdorp, P. M., Eaves, C. J., Hogge, D. E., Dragowska, W. H., Reid, D. S., Largman, C., Lawrence, H. J., & Humphries, R. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12223 · Cited by 497
Self-citation
Divergent homeo box proteins recognize similar DNA sequences in Drosophila
Hoey, T., & Levine, M. (1988) · Nature · doi:10.1038/332858a0 · Cited by 490
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
Miyamoto, T., Weissman, I. L., & Akashi, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7521 · Cited by 465
JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells
Passegue, E. A., Wagner, E. F., & Weissman, I. L. (2004) · Cell · doi:10.1016/j.cell.2004.10.010 · Cited by 442
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9Preprint
Ayton, P. M., & Cleary, M. L. (2003) · Genes & Development · doi:10.1101/gad.1111603 · Cited by 438
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
Xin, L., Lawson, D. A., & Witte, O. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502320102 · Cited by 426
Expressing the human genome
Tupler, R. G., Perini, G., & Green, M. R. (2001) · Nature · doi:10.1038/35057011 · Cited by 419
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
Soulier, J., Clappier, E., Cayuela, J., Régnault, A., García-Peydró, M., Dombret, H., Baruchel, A., Toribio, M. L., & Sigaux, F. (2005) · Blood · doi:10.1182/blood-2004-10-3900 · Cited by 400
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia
Taussig, D. C. (2005) · Blood · doi:10.1182/blood-2005-03-1072 · Cited by 379
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
Alcalay, M., Tiacci, E., Bergomas, R., Bigerna, B., Venturini, E., Minardi, S. P., Meani, N., Diverio, D., Bernard, L., Tizzoni, L., et al. (2005) · Blood · doi:10.1182/blood-2005-02-0560 · Cited by 362
CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity
Kasper, L. H., Brindle, P. K., Schnabel, C., Pritchard, C., Cleary, M., & van Deursen, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.764 · Cited by 357
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation
Ferrando, A. A., Armstrong, S. A., Neuberg, D. S., Sallan, S. E., Silverman, L. B., Korsmeyer, S. J., & Look, A. T. (2003) · Blood · doi:10.1182/blood-2002-10-3221 · Cited by 350
Overexpression of the myeloid leukemia–associatedHoxa9 gene in bone marrow cells induces stem cell expansion
Þorsteinsdóttir, U., Mamo, A., KROON, E. J., Jerome, L., Bijl, J. J., Lawrence, H. J., Humphries, R. K., & Sauvageau, G. (2002) · Blood · doi:10.1182/blood.v99.1.121 · Cited by 346
Self-citation
Meis1, a PBX1-Related Homeobox Gene Involved in Myeloid Leukemia in BXH-2 Mice
Moskow, J. J., Bullrich, F., Huebner, K., Daar, I. O., & Buchberg, A. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5434 · Cited by 335
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
Zeisig, B. B., Milne, T., García-Cuéllar, M.-P., Schreiner, S., Martin, M.-E., Fuchs, U., Borkhardt, A., Chanda, S. K., Walker, J. R., Soden, R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.617-628.2004 · Cited by 330
Overexpression of HOXA10 in Murine Hematopoietic Cells Perturbs both Myeloid and Lymphoid Differentiation and Leads to Acute Myeloid Leukemia
Þorsteinsdóttir, U., Sauvageau, G., Hough, M. R., Dragowska, W. H., Lansdorp, P. M., Lawrence, H. J., Largman, C., & Humphries, R. K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.495 · Cited by 323
Self-citation
The pathophysiology of HOX genes and their role in cancer
Dg, G., Thompson, A., Kwasniewska, A., McGonigle, G. J., Halliday, H. L., & Lappin, T. R. J. (2005) · The Journal of Pathology · doi:10.1002/path.1710 · Cited by 308
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Hisa, T., Spence, S. E., Rachel, R. A., Fujita, M., Nakamura, T., Ward, J. M., Devor-Henneman, D. E., Saiki, Y., Kutsuna, H., Tessarollo, L., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600038 · Cited by 306
Mice Bearing a Targeted Interruption of the Homeobox Gene HOXA9 Have Defects in Myeloid, Erythroid, and Lymphoid Hematopoiesis
Lawrence, H. J., Helgason, C. D., Sauvageau, G., Fong, S., Izon, D. J., Humphries, R. K., & Largman, C. (1997) · Blood · doi:10.1182/blood.v89.6.1922 · Cited by 303
Self-citation
Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
Amsellem, S., Pflumio, F., Bardinet, D., Izac, B., Charneau, P., Roméo, P., Dubart‐Kupperschmitt, A., & Fichelson, S. (2003) · Nature Medicine · doi:10.1038/nm953 · Cited by 295
Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia
Þorsteinsdóttir, U., KROON, E. J., Jerome, L., Blasi, F., & Sauvageau, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.224-234.2001 · Cited by 283
Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny
Pineault, N., Helgason, C. D., Lawrence, H. J., & Humphries, R. K. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00757-3 · Cited by 278
Self-citation
AbdB-Like Hox Proteins Stabilize DNA Binding by the Meis1 Homeodomain Proteins
Shen, W.-F., Montgomery, J. C., Rozenfeld, S. B., Moskow, J. J., Lawrence, H. J., Buchberg, A. M., & Largman, C. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6448 · Cited by 278
Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia
Ozeki, K. (2003) · Blood · doi:10.1182/blood-2003-06-1845 · Cited by 276
Maintenance of functional equivalence during paralogous Hox gene evolution
Greer, J. M., Puetz, J., Thomas, K. R., & Capecchi, M. R. (2000) · Nature · doi:10.1038/35001077 · Cited by 247
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
Davidson, A. J., Ernst, P., Wang, Y., Dekens, M. P. S., Kingsley, P. D., Palis, J., Korsmeyer, S. J., Daley, G. Q., & Zon, L. I. (2003) · Nature · doi:10.1038/nature01973 · Cited by 245
The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis
Lawrence, H. J., Sauvageau, G., Humphries, R. K., & Largman, C. (1996) · Stem Cells · doi:10.1002/stem.140281 · Cited by 241
Self-citation
Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−
Blair, A., Hogge, D. E., & Sutherland, H. J. (1998) · Blood · doi:10.1182/blood.v92.11.4325 · Cited by 239
Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.Preprint
Horan, G. S. B., Ramírez‐Solis, R., Featherstone, M., Wolgemuth, D. J., Bradley, A., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.13.1667 · Cited by 232
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia
Lin, Y., Slape, C. I., Zhang, Z., & Aplan, P. D. (2005) · Blood · doi:10.1182/blood-2004-12-4794 · Cited by 231
NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice
KROON, E. J., Þorsteinsdóttir, U., Mayotte, N., Nakamura, T., & Sauvageau, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.350 · Cited by 225
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells
Lawrence, H. J., Christensen, J. L., Fong, S., Hu, Y., Weissman, I. L., Sauvageau, G., Humphries, R. K., & Largman, C. (2005) · Blood · doi:10.1182/blood-2005-05-2003 · Cited by 223
Self-citation
Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias
Lawrence, H. J., Rozenfeld, S. B., Cruz, C., Matsukuma, K., Kwong, A., Kömüves, L. G., Buchberg, A. M., & Largman, C. (1999) · Leukemia · doi:10.1038/sj.leu.2401578 · Cited by 222
Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells
Kawagoe, H., Humphries, R. K., Blair, A., Sutherland, H., & Hogge, D. E. (1999) · Leukemia · doi:10.1038/sj.leu.2401410 · Cited by 222
Self-citation
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00681-6 · Cited by 221
Self-citation
Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications
Zákány, J., Fromental-Ramain, C., Warot, X. M., & Duboule, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13695 · Cited by 218
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
Ekker, S. C., Jackson, D. G., von Kessler, D. P., Sun, B. K., Young, K. E., & Beachy, P. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06662.x · Cited by 209
Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia
Drabkin, H., Parsy, C., Ferguson, K., Guilhot, F., Lacotte, L., Roy, L., Zeng, C. X., Barón, A. E., Hunger, S. P., Varella-Garcia, M., et al. (2002) · Leukemia · doi:10.1038/sj.leu.2402354 · Cited by 185
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis
Kato, Y., Iwama, A., Tadokoro, Y., Shimoda, K., Minoguchi, M., Akira, S., Tanaka, M., Miyajima, A., Kitamura, T., & Nakauchi, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042541 · Cited by 184
Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality
Rozovskaia, T., Feinstein, E., Mor, O., Foà, R., Blechman, J. A., Nakamura, T., Croce, C. M., Cimino, G. G., & Canaani, E. (2001) · Oncogene · doi:10.1038/sj.onc.1204174 · Cited by 181
Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation
Sauvageau, G., Þorsteinsdóttir, U., Hough, M. R., Hugo, P., Lawrence, H. J., Largman, C., & Humphries, R. K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80238-1 · Cited by 179
Self-citation
Leukaemic transformation by CALM–AF10 involves upregulation of Hoxa5 by hDOT1L
Okada, Y., Jiang, Q., Lemieux, M., Jeannotte, L., Su, L., & Zhang, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1464 · Cited by 179
An Mll-Dependent Hox Program Drives Hematopoietic Progenitor Expansion
Ernst, P., Mabon, M. E., Davidson, A. J., Zon, L. I., & Korsmeyer, S. J. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.012 · Cited by 179
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver
DiMartino, J. F., Selleri, L., Traver, D. J., Firpo, M. T., Rhee, J. W., Warnke, R. A., O’Gorman, S., Weissman, I. L., & Cleary, M. L. (2001) · Blood · doi:10.1182/blood.v98.3.618 · Cited by 172
The specificity of homeotic gene function
Mann, R. S. (1995) · BioEssays · doi:10.1002/bies.950171007 · Cited by 165
c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells
Hess, J. L., Bittner, C. B., Zeisig, D. T., Bach, C., Fuchs, U., Borkhardt, A., Frampton, J., & Slany, R. K. (2006) · Blood · doi:10.1182/blood-2005-12-5014 · Cited by 165
HOXandNon‐HOXHomeobox Genes in Leukemic Hematopoiesis
Owens, B. M., & Hawley, R. G. (2002) · Stem Cells · doi:10.1634/stemcells.20-5-364 · Cited by 165
Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
So, C. W. E., Karsunky, H., Wong, P., Weissman, I. L., & Cleary, M. L. (2004) · Blood · doi:10.1182/blood-2003-10-3722 · Cited by 158
Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells
Satoh, Y., Matsumura, I., Tanaka, H., Ezoe, S., Sugahara, H., Mizuki, M., Shibayama, H., Ishiko, E., Ishiko, J., Nakajima, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400407200 · Cited by 154
Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size
Þorsteinsdóttir, U., Sauvageau, G., & Humphries, R. K. (1999) · Blood · doi:10.1182/blood.v94.8.2605.420k19_2605_2612 · Cited by 154
Self-citation
Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
Jin, G., Yamazaki, Y., Takuwa, M., Takahara, T., Kaneko, K., Kuwata, T., Miyata, S., & Nakamura, T. (2007) · Blood · doi:10.1182/blood-2006-08-041202 · Cited by 149
Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1
Pineault, N., Buske, C., Feuring‐Buske, M., Abramovich, C., Rosten, P., Hogge, D. E., Aplan, P. D., & Humphries, R. K. (2003) · Blood · doi:10.1182/blood-2002-08-2484 · Cited by 148
Self-citation
Molecular characterization of acute leukemias by use of microarray technology
Kohlmann, A., Schoch, C., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W., & Haferlach, T. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10225 · Cited by 145
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo
Fischbach, N. A., Rozenfeld, S. B., Shen, W.-F., Fong, S., Chrobak, D., Ginzinger, D. G., Kogan, S. C., Radhakrishnan, A., Beau, M. M. L., Largman, C., et al. (2004) · Blood · doi:10.1182/blood-2004-04-1583 · Cited by 143
Mutations in Paralogous Hox Genes Result in Overlapping Homeotic Transformations of the Axial Skeleton: Evidence for Unique and Redundant Function
Horan, G. S. B., Kovács, E. N., Behringer, R. R., & Featherstone, M. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1150 · Cited by 141
Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
Brun, A. C. M., Björnsson, J. M., Magnusson, M., Larsson, N., Levéen, P., Ehinger, M., Nilsson, E., & Karlsson, S. (2004) · Blood · doi:10.1182/blood-2003-10-3557 · Cited by 139
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes
Dik, W. A., Brahim, W., Braun, C., Asnafi, V., Dastugue, N., Bernard, O., van Dongen, J. J. M., Langerak, A. W., Macintyre, E. A., & Delabesse, É. (2005) · Leukemia · doi:10.1038/sj.leu.2403891 · Cited by 138
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells
Buske, C. (2002) · Blood · doi:10.1182/blood-2002-01-0220 · Cited by 135
The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
van der Lugt, N. M. T., Alkema, M. J., Berns, A. J. M., & Deschamps, J. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00570-9 · Cited by 134
moz regulates Hox expression and pharyngeal segmental identity in zebrafish
Miller, C. T., Maves, L., & Kimmel, C. B. (2004) · Development · doi:10.1242/dev.01134 · Cited by 134
The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
Daser, A., & Rabbitts, T. H. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.01.007 · Cited by 131
Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
Kumar, A. R., Hudson, W. A., Chen, W., Nishiuchi, R., Yao, Q., & Kersey, J. H. (2003) · Blood · doi:10.1182/blood-2003-07-2582 · Cited by 130
Gene Expression Profiling of Acute Myeloid Leukemia with Translocation t(8;16)(p11;p13) and MYST3-CREBBP Rearrangement Reveals a Distinctive Signature with a Specific Pattern of HOX Gene Expression
Camós, M., Esteve, J., Jares, P., Colomer, D., Rozman, M., Villamor, N., Costa, D., Carrió, A., Nomdedeu, J. F., Montserrat, E., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4601 · Cited by 129
Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia
Deshpande, A. J., Cusan, M., Rawat, V. P. S., Reuter, H., Krause, A., Pott, C., Quintanilla‐Martínez, L., Kakadia, P. M., Kuchenbauer, F. C., Ahmed, F., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.023 · Cited by 126
Self-citation
Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus
Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2005) · Blood · doi:10.1182/blood-2004-12-4664 · Cited by 122
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
Speleman, F., Cauwelier, B., Dastugue, N., Cools, J., Verhasselt, B., Poppe, B. G., Roy, N. V., Vandesompele, J., Graux, C., Uyttebroeck, A., et al. (2005) · Leukemia · doi:10.1038/sj.leu.2403657 · Cited by 121
Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1
Calvo, K. R., Sykes, D. B., Pasillas, M. P., & Kamps, M. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205516 · Cited by 120
Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient inHoxb3andHoxb4
Bjürnsson, J. M., Larsson, N., Brun, A. C. M., Magnusson, M., Andersson, E., Lundstrüm, P., Larsson, J., Repetowska, E., Ehinger, M., Humphries, R. K., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.11.3872-3883.2003 · Cited by 120
Self-citation
The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis
Davidson, A. J., & Zon, L. I. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.01.003 · Cited by 119
Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation
Giampaolo, A., Sterpetti, P., Bulgarini, D., Samoggia, P., Pelosi, E., Valtieri, M., & Peschle, C. (1994) · Blood · doi:10.1182/blood.v84.11.3637.bloodjournal84113637 · Cited by 119
Targeted Mutations inHoxa-9andHoxb-9Reveal Synergistic Interactions
Chen, F., & Capecchi, M. R. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8440 · Cited by 116
NUP98 gene fusions in hematologic malignancies
Lam, D., & Aplan, P. (2001) · Leukemia · doi:10.1038/sj.leu.2402269 · Cited by 111
Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia
Fine, B. M., Stanulla, M., Schrappe, M., Ho, M., Viehmann, S. F., Harbott, J., & Boxer, L. M. (2003) · Blood · doi:10.1182/blood-2003-05-1518 · Cited by 108
Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics
Uchida, N., Dykstra, B. J., Lyons, K., Leung, F. Y. K., & Eaves, C. J. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.09.001 · Cited by 108
Hox C Cluster Genes Are Dispensable for Overall Body Plan of Mouse Embryonic Development
Suemori, H., & Noguchi, S. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9651 · Cited by 107
Loss of Function of the Homeobox Gene Hoxa-9 Perturbs Early T-Cell Development and Induces Apoptosis in Primitive Thymocytes
Izon, D. J., Rozenfeld, S. B., Fong, S. T., Kömüves, L. G., Largman, C., & Lawrence, H. J. (1998) · Blood · doi:10.1182/blood.v92.2.383 · Cited by 105
Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face
Crump, J. G., Swartz, M. E., Eberhart, J. K., & Kimmel, C. B. (2006) · Development · doi:10.1242/dev.02435 · Cited by 100
The Role of NUP98 Gene Fusions in Hematologic Malignancy
Slape, C. I., & Aplan, P. D. (2004) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190310001659325 · Cited by 99
Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes
Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3902-3916.2006 · Cited by 97
Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1
Pineault, N., Abramovich, C., Ohta, H., & Humphries, R. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1907-1917.2004 · Cited by 91
Self-citation
The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia.
Braekeleer, M. D., Morel, F., Bris, M. L., Herry, A., & Douet‐Guilbert, N. (2005) · PubMed · Cited by 90
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
Ghannam, G., Takeda, A., Camarata, T., Moore, M. A. S., Viale, A. J., & Yaseen, N. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307280200 · Cited by 87
Characterization of HOX Gene Expression During Myelopoiesis: Role of HOX A5 in Lineage Commitment and Maturation
Fuller, J. F., McAdara, J. K., Yaron, Y., Sakaguchi, M., Fraser, J. K., & Gasson, J. C. (1999) · Blood · doi:10.1182/blood.v93.10.3391.410k26_3391_3400 · Cited by 86
The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1
Krošl, J., Beslu, N., Mayotte, N., Humphries, R. K., & Sauvageau, G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00090-6 · Cited by 82
Self-citation
Frequent co‐expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement
Imamura, T., Morimoto, A., Takanashi, M., Hibi, S., Sugimoto, T., Ishii, E., & Imashuku, S. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03803.x · Cited by 82
Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements.
Tsutsumi, S., Taketani, T., Nishimura, K., Ge, X., Taki, T., Sugita, K., Ishii, E., Hanada, R., Ohki, M., Aburatani, H., et al. (2003) · PubMed · Cited by 81
Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model
岩崎, 正., Kuwata, T., Yamazaki, Y., Jenkins, N. A., Copeland, N. G., Osato, M., Ito, Y., KROON, E. J., Sauvageau, G., & Nakamura, T. (2004) · Blood · doi:10.1182/blood-2004-04-1508 · Cited by 77
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
Bansal, D., Scholl, C., Fröhling, S., McDowell, E. P., Lee, B. H., Döhner, K., Ernst, P., Davidson, A. J., Daley, G. Q., Zon, L. I., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604579103 · Cited by 75
Enforced Expression of NUP98-HOXA9 in Human CD34+ Cells Enhances Stem Cell Proliferation
Chung, K. Y., Morrone, G., Schuringa, J. J., Plasilova, M. L., Shieh, J.-H., Zhang, Y., Zhou, P., & Moore, M. A. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0706 · Cited by 75
Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells
Bijl, J. J. (2005) · Blood · doi:10.1182/blood-2005-06-2245 · Cited by 74
Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.
Shen, W. F., Detmer, K., Mathews, C. H. E., Hack, F. M., Morgan, D. A., Largman, C., & Lawrence, H. J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05137.x · Cited by 73
Continuous MLL-ENL Expression Is Necessary to Establish a “Hox Code” and Maintain Immortalization of Hematopoietic Progenitor Cells
Horton, S. J., Grier, D. G., McGonigle, G. J., Thompson, A., Morrow, M., Silva, I. D., MOULDING, D. A., Kioussis, D., Lappin, T. R. J., Brady, H. J. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1691 · Cited by 71
Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c- FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats
Bai, X., Gu, B.-W., Yin, T., Niu, C. S., Xi, X., Zhang, J., Zhu, C. H., & Chen, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3101 · Cited by 70
Molecular interactions involved in HOXB4-induced activation of HSC self-renewal
Beslu, N., Krošl, J., Laurin, M., Mayotte, N., Humphries, R. K., & Sauvageau, G. (2004) · Blood · doi:10.1182/blood-2004-04-1653 · Cited by 69
Self-citation
MEIS1 and HOXA7 genes in human acute myeloid leukemia
Afonja, O., Smith, J. E., Jr., Cheng, D. M., Goldenberg, A. S., Amorosi, E. L., Shimamoto, T., Nakamura, S., Ohyashiki, K., Ohyashiki, J. H., Toyama, K., et al. (2000) · Leukemia Research · doi:10.1016/s0145-2126(00)00059-x · Cited by 67
MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.
Schreiner, S., Birke, M. T., García-Cuéllar, M.-P., Zilles, O., Greil, J., & Slany, R. K. (2001) · PubMed · Cited by 64
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia
Palmqvist, L., Argiropoulos, B., Pineault, N., Abramovich, C., Sly, L. M., Krystal, G., Wan, A., & Humphries, R. K. (2006) · Blood · doi:10.1182/blood-2005-12-007005 · Cited by 62
Self-citation
NUP98 Fusion in Human Leukemia: Dysregulation of the Nuclear Pore and Homeodomain Proteins
Nakamura, T. (2005) · International Journal of Hematology · doi:10.1532/ijh97.04160 · Cited by 60
Identification of homeobox genes expressed in human haemopoietic progenitor cells
Moretti, P. A. B., Simmons, P. J., Thomas, P. Q., Haylock, D. N., Rathjen, P. D., Vadas, M. A., & D’Andrea, R. J. (1994) · Gene · doi:10.1016/0378-1119(94)90380-8 · Cited by 60
Expression ofHOXGenes in Acute Leukemia Cell Lines with and withoutMLLTranslocations
Quentmeier, H., Dirks, W. G., MacLeod, R. A. F., Reinhardt, J., Zaborski, M., & Drexler, H. G. (2003) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190310001609942 · Cited by 59
Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions
Ohta, H., Sekulovic, S., Bakovic, S., Eaves, C. J., Pineault, N., Gasparetto, M., Smith, C. A., Sauvageau, G., & Humphries, R. K. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.02.012 · Cited by 59
Self-citation
Functional Equivalence and Rescue Among Group 11HoxGene Products in Vertebral Patterning
Zákány, J., Gérard, M., Favier, B., Potter, S. S., & Duboule, D. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0137 · Cited by 55
Differential Effects of HOXB4 on Nonhuman Primate Short- and Long-Term Repopulating Cells
Zhang, X., Beard, B. C., Beebe, K., Storer, B. E., Humphries, R. K., & Kiem, H. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030173 · Cited by 55
Self-citation
Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique
Cauwelier, B., Cavé, H., Gervais, C., Lessard, M., Barin, C., Pérot, C., van den Akker, J., Mugneret, F., Charrin, C., Pagès, M.-P., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404410 · Cited by 53
Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation
Mamo, A. (2006) · Blood · doi:10.1182/blood-2005-06-2244 · Cited by 49
HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation
Bergeron, J., Clappier, E., Cauwelier, B., Dastugue, N., Millien, C., Delabesse, É., Beldjord, K., Speleman, F., Soulier, J., Macintyre, E. A., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404187 · Cited by 40
Transplantable cell lines generated with NUP98–Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA
Pineault, N., Abramovich, C., & Humphries, R. K. (2005) · Leukemia · doi:10.1038/sj.leu.2403696 · Cited by 38
Self-citation
HOXB gene expression and function in differentiating purified hematopoietic progenitors.
Giampaolo, A., Pelosi, E., Valtieri, M., Montesoro, E., Sterpetti, P., Samoggia, P., CAMAGNA, A., Mastroberardino, G., Gabbianelli, M., & Testa, U. (1995) · PubMed · Cited by 33
Ascorbate levels in red blood cells and urine in patients with sickle cell anemia
Westerman, M. P., Zhang, Y., McConnell, J. P., Chezick, P. A., Neelam, R., Freels, S. A., Feldman, L., Allen, S., Baridi, R., Feldman, L. E., et al. (2000) · American Journal of Hematology · doi:10.1002/1096-8652(200010)65:2 · Cited by 32
Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation
Morgado, E., Albouhair, S., & Lavau, C. (2007) · Blood · doi:10.1182/blood-2006-01-039586 · Cited by 28
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1lo hematopoietic stem cells
Cellot, S., Krošl, J., Chagraoui, J., Meloche, S., Humphries, R. K., & Sauvageau, G. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.02.013 · Cited by 28
Self-citation
Relationship between light intensity and phase resetting in a mammalian circadian system
Sharma, V. K., Chandrashekaran, M. K., Singaravel, M., & Subbaraj, R. (1999) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19990201)283:2 · Cited by 24
Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow
Ko, K., Lam, Q. L. K., Zhang, M., Wong, C. K. Y., Lo, C. K. C., Kahmeyer-Gabbe, M., Tsang, W. H., Tsang, S. L., Chan, L. C., Sham, M. H., et al. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2006.10.014 · Cited by 24
Signal transduction between red cells and other blood cells
Low, P. S., Li, Q., Kiyatkin, A. B., Rathinavelu, P., Geahlen, R. L., & Harrison, M. L. (1995) · Stem Cells · doi:10.1002/stem.5530130116 · Cited by 21

Sorted by citations

Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers
Chi, P., Allis, C. D., & Wang, G. G. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2876 · Cited by 1,131
Acute lymphoblastic leukaemia
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
The Hox genes and their roles in oncogenesis
Shah, N., & Sukumar, S. V. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2826 · Cited by 845
Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation
Buenrostro, J. D., Corces, M. R., Lareau, C. A., Wu, B., Schep, A. N., Aryee, M. J., Majeti, R., Chang, H. Y., & Greenleaf, W. J. (2018) · Cell · doi:10.1016/j.cell.2018.03.074 · Cited by 670

See all 498

Authors: Argiropoulos, B., & Humphries, R. K.
Affiliations: BC Cancer Agency (CA)
Corresponding author: Humphries, R K
ORCID: Argiropoulos, B
Humphries, R K
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2007-10-15
Volume: 26
Issue: 47
Pages: 6766-6776
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1210760
OpenAlex: W1976021347
Cited by: 492
References: 143
Citations by year: 2026: 8 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 22 · 2018: 20 · 2017: 28 · 2016: 28 · 2015: 27 · 2014: 38 · 2013: 43 · 2012: 38
FWCI: 4.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: Hox genes, hematopoiesis, leukemogenesis, hematopoietic stem cells, leukemia stem cells, MLL fusion, self-renewal, bone marrow transplantation, fusion oncogenes
MeSH terms: Animals, Genes, Homeobox, Hematopoiesis, Humans, Leukemia, Homeodomain Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hox genes in hematopoiesis and leukemogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks