The human dopamine D4 receptor repeat sequences modulate expression

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088

Multiple dopamine D4 receptor variants in the human population

Tol, H. H. M. V., Wu, C. M., Guan, H.-C., Ohara, K., Bunzow, J. R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H. B., & Jovanovic, V. (1992) · Nature · doi:10.1038/358149a0 · Cited by 955

Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants

Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858

Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder.

Faraone, S., Doyle, A., Mick, E., & Biederman, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1052 · Cited by 740

Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.

LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C. G., Wigal, T. L., King, N., & Kennedy, J. L. (1996) · PubMed · Cited by 678

A hypervariable segment in the human dopamine receptor D4 (DRD4) gene

Lichter, J. B., Barr, C. L., Kennedy, J. L., Tol, H. H. M. V., Kídd, K. K., & Livak, K. J. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.6.767 · Cited by 524

Evidence of positive selection acting at the human dopamine receptor D4 gene locus

Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506

The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms

Makeyev, A. V., & Liebhaber, S. A. (2002) · RNA · doi:10.1017/s1355838202024627 · Cited by 469

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

Chang, F., Kídd, K. K., Livak, K. J., PAKSTIS, A. J., & Kídd, K. K. (1996) · Human Genetics · doi:10.1007/s004390050166 · Cited by 438

Dopamine D4 Receptor-Knock-Out Mice Exhibit Reduced Exploration of Novel Stimuli

Dulawa, S. C., Grandy, D. K., Low, M. J., Paulus, M. P., & Geyer, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09550.1999 · Cited by 432

The dopamine D4 receptor: one decade of research

Oak, J. N., Oldenhof, J., & Tol, H. H. M. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00562-8 · Cited by 421

Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention

Swanson, J., Oosterlaan, J., Murias, M., Schuck, S., Flodman, P., Spence, M. A., Wasdell, M., Ding, Y., Chi, H.-C., Smith, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080070897 · Cited by 267

Translation of 15‐lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

Ostareck‐Lederer, A., Ostareck, D. H., Standart, N., & Thiele, B. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06402.x · Cited by 257

Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes.

Asghari, V, Schoots, O., van Kats, S., Ohara, K., Jovanovic, V, Guan, H. C., Bunzow, J. R., Petronis, A., & Van Tol, H. H. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09692-0 · Cited by 239

A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor Transmission

Kotecha, S. A., Oak, J. N., Jackson, M. F., Perez, Y., Orser, B. A., Tol, H. H. M. V., & MacDonald, J. F. (2002) · Neuron · doi:10.1016/s0896-6273(02)00859-0 · Cited by 229

Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase.

Cohen, A. I., Todd, R. D., Harmon, S. K., & O’Malley, K. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12093 · Cited by 202

Polymorphisms in dopamine receptors: what do they tell us?

Wong, A. H. C., Buckle, C. E., & Tol, H. H. M. V. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00815-3 · Cited by 176

Dopamine D4Receptors Modulate GABAergic Signaling in Pyramidal Neurons of Prefrontal Cortex

Wang, X., Zhong, P., & Yan, Z. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09185.2002 · Cited by 155

Object-oriented Transcription Factors Database (ooTFD)

GHOSH, D. K. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.308 · Cited by 131

Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants

Jovanović, V., Guan, H., & Tol, H. H. M. V. (1999) · Pharmacogenetics · doi:10.1097/00008571-199910000-00003 · Cited by 116

Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors

Nir, I., Harrison, J. M., Haque, R., Low, M. J., Grandy, D. K., Rubinstein, M., & Iuvone, P. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02063.2002 · Cited by 114

Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear

Falzone, T. L., Gelman, D. M., Young, J. I., Grandy, D. K., Low, M. J., & Rubinstein, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01842.x · Cited by 109

Dopamine D 4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys

Jentsch, J. D., Taylor, J. R., Redmond, D. E., Elsworth, J. D., Youngren, K. D., & Roth, R. H. (1999) · Psychopharmacology · doi:10.1007/s002130050865 · Cited by 89

Selective Reconstitution of Human D4 Dopamine Receptor Variants with G i α Subtypes

Kazmi, M. A., Snyder, L., Cypess, A. M., Graber, S. G., & Sakmar, T. P. (2000) · Biochemistry · doi:10.1021/bi992354c · Cited by 66

The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys

Arnsten, A. F. T. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00133-0 · Cited by 64

Dopamine D4 Receptors

Helmeste, D. M., & Tang, S. W. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.82.1 · Cited by 62

Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3′-UTR control element DICE

Reimann, I., Huth, A., Thiele, H., & Thiele, B. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5315 · Cited by 61

Genomic Organization and Promoter Analysis of the Human G-Protein-Coupled K+Channel Kir3.1 (KCNJ3/HGIRK1)

Schoots, O., Voskoglou, T., & Tol, H. H. M. V. (1997) · Genomics · doi:10.1006/geno.1996.4495 · Cited by 33

TransTerm, the translational signal database, extended to include full coding sequences and untranslated regions

Dalphin, M. E., Stockwell, P. A., Tate, W. P., & Brown, C. M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.293 · Cited by 28

Dopamine D4 Receptor-Mediated Inhibition of Cyclic Adenosine 3',5'-Monophosphate Production Does Not Affect Prolactin Regulation

Sanyal, S., & Tol, H. H. M. V. (1997) · Endocrinology · doi:10.1210/endo.138.5.5145 · Cited by 17

Promoter‐independent regulation of cell‐specific dopamine receptor expression

Knapp, M., Wong, A. H. C., Schoots, O., Guan, H. C., & Tol, H. H. M. V. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00961-2 · Cited by 9

Genetics of dopamine receptors and drug addiction: a comprehensive review

Foll, B. L., Gallo, A., Strat, Y. L., Lü, L., & Gorwood, P. A. P. M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283242f05 · Cited by 395

The molecular genetic architecture of human personality: beyond self-report questionnaires

Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001814 · Cited by 367

Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study.

Eisenberg, D. T. A., MacKillop, J., Modi, M. E., Beauchemin, J., Dang, D., Lisman, S. A., Lum, J. K., & Wilson, D. S. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-2 · Cited by 264

The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men

Dreber, A., Apicella, C. L., Eisenberg, D. T. A., Garcia, J. R., Zamore, R. S., Lum, J. K., & Campbell, B. (2009) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2008.11.001 · Cited by 217

Dopamine receptor genetic polymorphisms and body composition in undernourished pastoralists: An exploration of nutrition indices among nomadic and recently settled Ariaal men of northern Kenya

Eisenberg, D. T. A., Campbell, B., Gray, P. B., & Sorenson, M. D. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-173 · Cited by 197

Allele‐specific transcriptional activity of the variable number of tandem repeats in 5′ region of the DRD4 gene is stimulus specific in human neuronal cells

Paredes, U. M., Quinn, J. P., & D'Souza, U. M. (2013) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00857.x · Cited by 10

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression

Fuke, S., Suo, S., Takahashi, N., Koike, H., Sasagawa, N., & Ishiura, S. (2001) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500026 · Cited by 415

Repeat sequences in the gene encoding the human D4 dopamine receptor

O’Dowd, B. F. (1992) · Gene · doi:10.1016/0378-1119(92)90207-6 · Cited by 9

Echoes of D4 receptor repeats

MAKOFF, A. J. (1992) · Nature · doi:10.1038/360424a0 · Cited by 2

Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression

Miller, G. M., & Madras, B. K. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000921 · Cited by 233