Infantile zinc deficiency: Association with autism spectrum disorders
Open accessAbstract
Elucidation of the pathogenesis and effective treatment of autism spectrum disorders is one of the challenges today. In this study, we examine hair zinc concentrations for 1,967 children with autistic disorders (1,553 males and 414 females), and show considerable association with zinc deficiency. Histogram of hair zinc concentration was non-symmetric with tailing in lower range, and 584 subjects were found to have lower zinc concentrations than -2 standard deviation level of its reference range (86.3-193 ppm). The incidence rate of zinc deficiency in infant group aged 0-3 year-old was estimated 43.5 % in male and 52.5 % in female. The lowest zinc concentration of 10.7 ppm was detected in a 2-year-old boy, corresponding to about 1/12 of the control mean level. These findings suggest that infantile zinc deficiency may epigenetically contribute to the pathogenesis of autism and nutritional approach may yield a novel hope for its treatment and prevention.
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Low levels of zinc have been measured in the infant hair of individuals with ASD.
“Low levels of zinc have been measured in the infant hair of individuals with ASD [170]”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [170]
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References 53 · Cited by 185
- Authors
- Yasuda, H., Yoshida, K., Yasuda, Y., & Tsutsui, T.
- Corresponding author
- Yasuda, Hiroshi
- Venue
- Scientific Reports
- Published
- 2011-11-03
- Volume
- 1
- Issue
- 1
- Pages
- 129-129
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3216610
- OpenAlex
- W2169507217
- Cited by
- 185
- References
- 53
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 19 · 2021: 15 · 2020: 21 · 2019: 11 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 8 · 2014: 10 · 2013: 15 · 2012: 5
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- autism spectrum disorder, zinc status, autism pathogenesis, dietary intervention, epigenetics
- MeSH terms
- Adolescent, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Hair, Humans, Infant, Infant, Newborn, Japan, Male, Reference Values, Zinc, Incidence, Epigenesis, Genetic
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