The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Development of Miniaturized Walking Biological Machines
Open accessAbstract
The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the bio-bot, and a base structure to define the asymmetric shape for locomotion. The cantilever structure was seeded with a sheet of contractile cardiomyocytes. We evaluated the locomotive mechanisms of several designs of bio-bots by changing the cantilever thickness. The bio-bot that demonstrated the most efficient mechanism of locomotion maximized the use of contractile forces for overcoming friction of the supporting leg, while preventing backward movement of the actuating leg upon relaxation. The maximum recorded velocity of the bio-bot was ~236 µm s(-1), with an average displacement per power stroke of ~354 µm and average beating frequency of ~1.5 Hz.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Muscular Thin Films for Building Actuators and Powering Devices
Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765
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Soft robotics: a bioinspired evolution in robotics
Kim, S., Laschi, C., & Trimmer, B. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2013.03.002 · Cited by 2,092
Phototactic guidance of a tissue-engineered soft-robotic ray
Park, S.-J., Gazzola, M., Park, K. S., Park, S., Di Santo, V., Blevins, E. L., Lind, J. U., Campbell, P. H., Dauth, S., Capulli, A. K., et al. (2016) · Science · doi:10.1126/science.aaf4292 · Cited by 721
Self-citation3D biofabrication strategies for tissue engineering and regenerative medicine
Bajaj, P., Schweller, R. M., Khademhosseini, A., West, J. L., & Bashir, R. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105155 · Cited by 632
Self-citationYang, Y., Song, X., Li, X., Chen, Z., Zhou, C., Zhou, Q., & Chen, Y. (2018) · Advanced Materials · doi:10.1002/adma.201706539 · Cited by 538
Biohybrid actuators for robotics: A review of devices actuated by living cells
Ricotti, L., Trimmer, B., Feinberg, A. W., Raman, R., Parker, K. K., Bashir, R., Sitti, M., Martel, S., Dario, P., & Menciassi, A. (2017) · Science Robotics · doi:10.1126/scirobotics.aaq0495 · Cited by 527
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Metadata
- Authors
- Chan, V., Park, K., Collens, M. B., Kong, H., Saif, T. A., & Bashir, R.
- Venue
- Scientific Reports
- Published
- 2012-11-15
- Volume
- 2
- Issue
- 1
- Pages
- 857-857
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2151203874
- Cited by
- 228
- References
- 3
- FWCI
- 21.07
- Type
- journal article
- Language
- en
- Open access
- gold
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