Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering

Hydrogels for tissue engineering: scaffold design variables and applications

Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136 · see citing works

Cell Migration: Integrating Signals from Front to Back

Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 4,929 · see citing works

Hydrogels for biomedical applications

Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864 · see citing works

How Matrix Metalloproteinases Regulate Cell Behavior

Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959 · see citing works

Integrin signaling

Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869 · see citing works

Fabrication of novel biomaterials through molecular self-assembly

Zhang, S. (2003) · Nature Biotechnology · doi:10.1038/nbt874 · Cited by 3,353 · see citing works

Designing materials for biology and medicine

Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198 · see citing works

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191 · see citing works

Taking Cell-Matrix Adhesions to the Third Dimension

Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027 · see citing works

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

Hersel, U., Dahmen, C., & Kessler, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00343-0 · Cited by 2,590 · see citing works

Tissue Engineering--Current Challenges and Expanding Opportunities

Griffith, L. G., & Naughton, G. K. (2002) · Science · doi:10.1126/science.1069210 · Cited by 2,348 · see citing works

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

Geiger, B., Bershadsky, A. D., Pankov, R. G., & Yamada, K. M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099066 · Cited by 2,213 · see citing works

Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers

Silva, G. A., Czeisler, C. M., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,169 · see citing works

Water Gelation by Small Organic Molecules

Estroff, L. A., & Hamilton, A. D. (2004) · Chemical Reviews · doi:10.1021/cr0302049 · Cited by 2,038 · see citing works

Novel crosslinking methods to design hydrogels

Hennink, W. E., & van Nostrum, C. F. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00240-x · Cited by 1,979 · see citing works

Out of Eden: Stem Cells and Their Niches

Watt, F. M., & Hogan, A. B. L. M. (2000) · Science · doi:10.1126/science.287.5457.1427 · Cited by 1,754 · see citing works

Polymeric system for dual growth factor delivery

Richardson, T. P., Peters, M. C., Ennett, A. B., & Mooney, D. J. (2001) · Nature Biotechnology · doi:10.1038/nbt1101-1029 · Cited by 1,753 · see citing works

Socializing with the Neighbors

Fuchs, E. V., Tumbar, T., & Guasch, G. (2004) · Cell · doi:10.1016/s0092-8674(04)00255-7 · Cited by 1,711 · see citing works

Biomimetic materials for tissue engineering

Shin, H., Jo, S., & Mikos, A. G. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00339-9 · Cited by 1,616 · see citing works

Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics

Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., & Hubbell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737381100 · Cited by 1,508 · see citing works

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

Palecek, S. P., Loftus, J. C., Ginsberg, M. H., Lauffenburger, D. A., & Horwitz, A. F. (1997) · Nature · doi:10.1038/385537a0 · Cited by 1,427 · see citing works

Compensation mechanism in tumor cell migration

Wolf, K., Mazo, I. B., Leung, H. C. H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Bröcker, E., & Friedl, P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209006 · Cited by 1,392 · see citing works

Biology's new dimension

Abbott, A. (2003) · Nature · doi:10.1038/424870a · Cited by 1,237 · see citing works

New Challenges in Biomaterials

Peppas, N. A., & Langer, R. (1994) · Science · doi:10.1126/science.8134835 · Cited by 1,145 · see citing works

Mesenchymal stem cells: building blocks for molecular medicine in the 21st century

Caplan, A. I., & Bruder, S. P. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02016-0 · Cited by 1,138 · see citing works

Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds

Holmes, T. C., Lacalle, S. D., Su, X., Liu, G., Rich, A., & Zhang, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6728 · Cited by 1,124 · see citing works

Reversible Hydrogels from Self-Assembling Artificial Proteins

Petka, W. A., Harden, J. L., McGrath, K. P., Wirtz, D., & Tirrell, D. A. (1998) · Science · doi:10.1126/science.281.5375.389 · Cited by 1,076 · see citing works

Biomaterials in Tissue Engineering

Hubbell, J. A. (1995) · Nature Biotechnology · doi:10.1038/nbt0695-565 · Cited by 1,060 · see citing works

Living Tissue Formed in Vitro and Accepted as Skin-Equivalent Tissue of Full Thickness

Bell, E., Ehrlich, H. P., Buttle, D. J., & Nakatsuji, T. (1981) · Science · doi:10.1126/science.7008197 · Cited by 1,054 · see citing works

Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair

Kisiday, J. D., Jin, M. M., Kurz, B., Hung, H.-H. K., Semino, C. E., Zhang, S., & Grodzinsky, A. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142309999 · Cited by 1,045 · see citing works

Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.2.1.9 · Cited by 1,016 · see citing works

Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin

Yannas, I. V., Lee, E., Orgill, D. P., Skrabut, E. M., & Murphy, G. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.933 · Cited by 972 · see citing works

Cell adhesion and motility depend on nanoscale RGD clustering

Maheshwari, G., Brown, G., Lauffenburger, D. A., Wells, A. H., & Griffith, L. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.10.1677 · Cited by 951 · see citing works

Cell interactions with three-dimensional matrices

Cukierman, E., Pankov, R. G., & Yamada, K. M. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00364-2 · Cited by 889 · see citing works

An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation.

Massia, S. P., & Hubbell, J. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.5.1089 · Cited by 879 · see citing works

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

Weissman, I. L. (2000) · Science · doi:10.1126/science.287.5457.1442 · Cited by 852 · see citing works

Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

Lutolf, M. P., Weber, F. E., Schmoekel, H. G., Schense, J. C., Kohler, T., Müller, R., & Hubbell, J. A. (2003) · Nature Biotechnology · doi:10.1038/nbt818 · Cited by 850 · see citing works

Fibroblast biology in three-dimensional collagen matrices

Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819 · see citing works

Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles

Nowak, A. P., Breedveld, V., Pakstis, L., Ozbas, B., Pine, D. J., Pochan, D. J., & Deming, T. J. (2002) · Nature · doi:10.1038/417424a · Cited by 809 · see citing works

De novo reconstitution of a functional mammalian urinary bladder by tissue engineering

Oberpenning, F., Meng, J., Yoo, J., & Atala, A. (1999) · Nature Biotechnology · doi:10.1038/6146 · Cited by 800 · see citing works

Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells

Anderson, D. G., Levenberg, S., & Langer, R. (2004) · Nature Biotechnology · doi:10.1038/nbt981 · Cited by 747 · see citing works

Biomolecule-sensitive hydrogels

Miyata, T., Uragami, T., & Nakamae, K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00241-1 · Cited by 736 · see citing works

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering

Mann, B. K., Gobin, A. S., Tsai, A. T., Schmedlen, R. H., & West, J. L. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00051-5 · Cited by 705 · see citing works

Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds

Levenberg, S., Huang, N. F., Lavik, E., Rogers, A. B., Itskovitz‐Eldor, J., & Langer, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735463100 · Cited by 691 · see citing works

Prespecification and plasticity: shifting mechanisms of cell migration

Friedl, P. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.001 · Cited by 670 · see citing works

The biology of cell locomotion within three-dimensional extracellular matrix

Friedl, P., & Br�cker, E.-B. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050498 · Cited by 664 · see citing works

Integrin signaling and cell growth control

Howe, A. K., Aplin, A. E., Alahari, S. K., & Juliano, R. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80144-0 · Cited by 654 · see citing works

Polymeric Biomaterials with Degradation Sites for Proteases Involved in Cell Migration

West, J. L., & Hubbell, J. A. (1998) · Macromolecules · doi:10.1021/ma981296k · Cited by 627 · see citing works

Mathematical model for the effects of adhesion and mechanics on cell migration speed

DiMilla, P. A., Barbee, K., & Lauffenburger, D. A. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82027-6 · Cited by 626 · see citing works

Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains

Wang, C., Stewart, R. J., & Kopec̆ek, J. (1999) · Nature · doi:10.1038/17092 · Cited by 583 · see citing works

Modeling tissue-specific signaling and organ function in three dimensions

Schmeichel, K. L., & Bissell, M. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00503 · Cited by 583 · see citing works

Semi-wet peptide/protein array using supramolecular hydrogel

Kiyonaka, S., Sada, K., Yoshimura, I., Shinkai, S., Kato, N., & Hamachi, I. (2003) · Nature Materials · doi:10.1038/nmat1034 · Cited by 559 · see citing works

The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

Park, K. I., Teng, Y. D., & Snyder, E. Y. (2002) · Nature Biotechnology · doi:10.1038/nbt751 · Cited by 554 · see citing works

Cell‐demanded release of VEGF from synthetic, biointeractive cell‐ingrowth matrices for vascularized tissue growth

Zisch, A. H., Lütolf, M. P., Ehrbar, M., Raeber, G. P., Rizzi, S. C., Davies, N. H., Schmoekel, H. G., Bezuidenhout, D., Djonov, V., Zilla, P., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1041fje · Cited by 534 · see citing works

Cell‐Responsive Synthetic Hydrogels

Lütolf, M. P., Raeber, G. P., Zisch, A. H., Tirelli, N., & Hubbell, J. A. (2003) · Advanced Materials · doi:10.1002/adma.200304621 · Cited by 526 · see citing works

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis

Ozawa, C. R., Banfi, A., Glazer, N. L., Thurston, G., Springer, M. L., Kraft, P. E., McDonald, D. M., & Blau, H. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18420 · Cited by 517 · see citing works

Role of the extracellular matrix in morphogenesis

Kleinman, H. K., Philp, D., & Hoffman, M. P. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.002 · Cited by 484 · see citing works

Bioactive biomaterials

Hubbell, J. A. (1999) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(99)80021-4 · Cited by 474 · see citing works

The application of bone morphogenetic proteins to dental tissue engineering

Nakashima, M., & Reddi, A. H. (2003) · Nature Biotechnology · doi:10.1038/nbt864 · Cited by 472 · see citing works

Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction

Niece, K. L., Hartgerink, J. D., Donners, J. J. J. M., & Stupp, S. I. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028215r · Cited by 462 · see citing works

Polymeric Growth Factor Delivery Strategies for Tissue Engineering

Chen, R. R., & Mooney, D. J. (2003) · Pharmaceutical Research · doi:10.1023/a:1025034925152 · Cited by 435 · see citing works

Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus

Koo, L. Y., Irvine, D. J., Mayes, A. M., Lauffenburger, D. A., & Griffith, L. G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1423 · Cited by 420 · see citing works

Protein-based materials, toward a new level of structural control

van Hest, J. C. M., & Tirrell, D. A. (2001) · Chemical Communications · doi:10.1039/b105185g · Cited by 416 · see citing works

The Use of Fibrin Glue in Skin Grafts and Tissue-Engineered Skin Replacements: A Review

Currie, L. J., Sharpe, J. R., & Martin, R. H. (2001) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200111000-00045 · Cited by 390 · see citing works

The application of recombinant human collagen in tissue engineering

Yang, C., Hillas, P. J., B??ez, J. A., Nokelainen, M., Balan, J., Tang, J., Spiro, R., & Polarek, J. W. (2004) · BioDrugs · doi:10.2165/00063030-200418020-00004 · Cited by 385 · see citing works

Materials as morphogenetic guides in tissue engineering

Hubbell, J. A. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.09.004 · Cited by 380 · see citing works

Emerging Design Principles in Biomaterials and Scaffolds for Tissue Engineering

Griffith, L. G. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03056.x · Cited by 372 · see citing works

Electrospinning of poly(ethylene-co-vinyl alcohol) fibers

Kenawy, E., Layman, J. M., Watkins, J. R., Bowlin, G. L., Matthews, J. A., Simpson, D. G., & Wnek, G. E. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00422-2 · Cited by 359 · see citing works

Biopolymeric delivery matrices for angiogenic growth factors

Zisch, A. H., Lütolf, M. P., & Hubbell, J. A. (2003) · Cardiovascular Pathology · doi:10.1016/s1054-8807(03)00089-9 · Cited by 357 · see citing works

Cell-Demanded Liberation of VEGF 121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth

Ehrbar, M., Djonov, V., Schnell, C., Tschanz, S. A., Martiny‐Baron, G., Schenk, U., Wood, J. M., Burri, P. H., Hubbell, J. A., & Zisch, A. H. (2004) · Circulation Research · doi:10.1161/01.res.0000126411.29641.08 · Cited by 357 · see citing works

The stem-cell niche theory: lessons from flies

Lin, H. (2002) · Nature Reviews Genetics · doi:10.1038/nrg952 · Cited by 355 · see citing works

Covalently conjugated VEGF–fibrin matrices for endothelialization

Zisch, A. H., Schenk, U., Schense, J. C., Sakiyama‐Elbert, S. E., & Hubbell, J. A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00266-8 · Cited by 350 · see citing works

Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

Basbaum, C. B., & Werb, Z. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80116-5 · Cited by 324 · see citing works

Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds

Semino, C. E., Merok, J. R., Crane, G. G., Panagiotakos, G., & Zhang, S. (2003) · Differentiation · doi:10.1046/j.1432-0436.2003.7104503.x · Cited by 319 · see citing works

Biologically Engineered Protein-graft-Poly(ethylene glycol) Hydrogels: A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair

Halstenberg, S., Panitch, A., Rizzi, S. C., Hall, H., & Hubbell, J. A. (2002) · Biomacromolecules · doi:10.1021/bm015629o · Cited by 315 · see citing works

Synthesis and Characterization of Injectable Poly(N-isopropylacrylamide-co-acrylic acid) Hydrogels with Proteolytically Degradable Cross-Links

Kim, S., & Healy, K. E. (2003) · Biomacromolecules · doi:10.1021/bm0340467 · Cited by 303 · see citing works

Smart and genetically engineered biomaterials and drug delivery systems

Kopec̆ek, J. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(03)00164-7 · Cited by 292 · see citing works

Forces on adhesive contacts affect cell function

Galbraith, C. G., & Sheetz, M. P. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80030-6 · Cited by 273 · see citing works

A Combinatorial Approach for Polymer Design

Brocchini, S., James, K., Tangpasuthadol, V., & Kohn, J. (1997) · Journal of the American Chemical Society · doi:10.1021/ja970389z · Cited by 260 · see citing works

Cell migration through defined, synthetic extracellular matrix analogues

Gobin, A. S., & West, J. L. (2002) · The FASEB Journal · doi:10.1096/fj.01-0759fje · Cited by 257 · see citing works

Engineering the morphology of a self-assembling protein fibre

Ryadnov, M. G., & Woolfson, D. N. (2003) · Nature Materials · doi:10.1038/nmat885 · Cited by 256 · see citing works

Molecular basis of endothelial cell morphogenesis in three‐dimensional extracellular matrices

Davis, G. E., Bayless, K. J., & Mavila, A. (2002) · The Anatomical Record · doi:10.1002/ar.10159 · Cited by 247 · see citing works

Synthetic extracellular matrices for in situ tissue engineering

Pratt, A. B., Weber, F. E., Schmoekel, H. G., Müller, R., & Hubbell, J. A. (2004) · Biotechnology and Bioengineering · doi:10.1002/bit.10897 · Cited by 230 · see citing works

Engineering the Extracellular Matrix: A Novel Approach to Polymeric Biomaterials. I. Control of the Physical Properties of Artificial Protein Matrices Designed to Support Adhesion of Vascular Endothelial Cells

Welsh, E. R., & Tirrell, D. A. (2000) · Biomacromolecules · doi:10.1021/bm0002914 · Cited by 217 · see citing works

Supramolecular chemistry and self-assembly

Menger, F. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062524299 · Cited by 213 · see citing works

Manipulating angiogenesis in medicine

Carmeliet, P. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01297.x · Cited by 208 · see citing works

Comparative Cell Response to Artificial Extracellular Matrix Proteins Containing the RGD and CS5 Cell-Binding Domains

Liu, J. C., Heilshorn, S. C., & Tirrell, D. A. (2004) · Biomacromolecules · doi:10.1021/bm034340z · Cited by 188 · see citing works

Development of growth factor fusion proteins for cell‐triggered drug delivery

Sakiyama‐Elbert, S. E., Panitch, A., & Hubbell, J. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0564fje · Cited by 181 · see citing works

Protein-based signaling systems in tissue engineering

Boontheekul, T., & Mooney, D. J. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.004 · Cited by 180 · see citing works

Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration

Kuntz, R. M., & Saltzman, W. M. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78793-9 · Cited by 175 · see citing works

Three-dimensional Migration of Neurites Is Mediated by Adhesion Site Density and Affinity

Schense, J. C., & Hubbell, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6813 · Cited by 163 · see citing works

Cell signaling events: a view from the matrix

Ramirez, F., & Rifkin, D. B. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00002-7 · Cited by 163 · see citing works

Elastic protein-based polymers in soft tissue augmentation and generation

Urry, D. W., Pattanaik, A., Xu, J., Woods, T. C., McPherson, D. T., & Parker, T. M. (1998) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856298x00316 · Cited by 163 · see citing works

Biophysical Integration of Effects of Epidermal Growth Factor and Fibronectin on Fibroblast Migration

Maheshwari, G., Wells, A. H., Griffith, L. G., & Lauffenburger, D. A. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77435-7 · Cited by 154 · see citing works

Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands

Irvine, D. J., Hue, K., Mayes, A. M., & Griffith, L. G. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75379-4 · Cited by 143 · see citing works

Transplantation of brain cells assembled around a programmable synthetic microenvironment

Mahoney, M. J., & Saltzman, W. M. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-934 · Cited by 134 · see citing works

Biomaterials and Scaffolds in Reparative Medicine

Chaikof, E. L., Matthew, H. W. T., Kohn, J., Mikos, A. G., Prestwich, G. D., & Yip, C. M. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03057.x · Cited by 124 · see citing works

Stem cells in regenerative biology and medicine

Stocum, D. L. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00429.x · Cited by 101 · see citing works

Molecular Signaling in Bioengineered Tissue Microenvironments

Bottaro, D. P., Liebmann-Vinson, A., & Heidaran, M. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03068.x · Cited by 101 · see citing works

Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide

Brandley, B. K., & Schnaar, R. L. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90159-0 · Cited by 95 · see citing works

Three‐dimensional culture of differentiating marrow stromal osteoblasts in biomimetic poly(propylene fumarate‐co‐ethylene glycol)‐based macroporous hydrogels

Behravesh, E., & Mikos, A. G. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10003 · Cited by 86 · see citing works

Effect of Chemistry and Morphology on the Biofunctionality of Self-Assembling Diblock Copolypeptide Hydrogels

Pakstis, L., Ozbas, B., Hales, K., Nowak, A. P., Deming, T. J., & Pochan, D. J. (2003) · Biomacromolecules · doi:10.1021/bm034249v · Cited by 79 · see citing works

Tissue engineering strategies for in vivo neovascularisation

Ennett, A. B., & Mooney, D. J. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.8.805 · Cited by 77 · see citing works

Elastic molecular machines in metabolism and soft-tissue restoration

Urry, D. W., & Urry, D. W. (1999) · Trends in biotechnology · doi:10.1016/s0167-7799(99)01306-2 · Cited by 76 · see citing works

Integration of Combinatorial Synthesis, Rapid Screening, and Computational Modeling in Biomaterials Development

Smith, J. R., Seyda, A., Weber, N., KNIGHT, D. D., Abramson, S. D., & Kohn, J. (2004) · Macromolecular Rapid Communications · doi:10.1002/marc.200300193 · Cited by 72 · see citing works

Taking stock and planning for the next decade: Realistic prospects for stem cell therapies for the nervous system

Snyder, E. Y., Daley, G. Q., & Goodell, M. A. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20033 · Cited by 72 · see citing works

Quantitative Analysis of Adhesion-Mediated Cell Migration in Three-Dimensional Gels of RGD-Grafted Collagen

Burgess, B. T., Myles, J. L., & Dickinson, R. B. (2000) · Annals of Biomedical Engineering · doi:10.1114/1.259 · Cited by 67 · see citing works

Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain

Ulbrich, K., Zacharieva, E. I., Obereigner, B., & Kopec̆ek, J. (1980) · Biomaterials · doi:10.1016/0142-9612(80)90017-4 · Cited by 63 · see citing works

Regenerative biology and engineering: strategies for tissue restoration

Stocum, D. L. (1998) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1998.60404.x · Cited by 46 · see citing works

Apical (Retrograde) Peri-implantitis: A Case Report of an Active Lesion

Flanagan, D. (2002) · Journal of Oral Implantology · doi:10.1563/1548-1336(2002)028 · Cited by 43 · see citing works

Artificial Niches for Human Adult Neural Stem Cells: Possibility for Autologous Transplantation Therapy

Liu, C. Y., Westerlund, U., Svensson, M. A., Moe, M. C., Varghese, M., Berg–Johnsen, J., Apuzzo, M. L. J., Tirrell, D. A., & Langmoen, I. A. (2003) · Stem Cells and Development · doi:10.1089/15258160360732713 · Cited by 37 · see citing works

Engineering of the Extracellular Matrix: Working toward Neural Stem Cell Programming and Neurorestoration— Concept and Progress Report

Liu, C., Apuzzo, M., & Tirrell, D. (2003) · Neurosurgery · doi:10.1227/01.neu.0000057747.93237.8f · Cited by 30 · see citing works

Engineering the extracellular matrix : a novel approach to polymeric biomaterials.

Welsh, E. R. (1999) · Scholarworks (University of Massachusetts Amherst) · doi:10.7275/10431 · Cited by 22 · see citing works

Wound repair and regeneration

Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works

The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334 · see citing works

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works

Chitosan—A versatile semi-synthetic polymer in biomedical applications

Dash, M., Chiellini, E., Ottenbrite, R. M., & Chiellini, E. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.02.001 · Cited by 2,920 · see citing works

Hydrogels as extracellular matrix mimics for 3D cell culture

Tibbitt, M. W., & Anseth, K. S. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22361 · Cited by 2,727 · see citing works

Hydrogels in regenerative medicine

Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703 · see citing works

Exploring and Engineering the Cell Surface Interface

Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607 · see citing works

Chitosan-based hydrogels for controlled, localized drug delivery

Bhattarai, N., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.019 · Cited by 2,457 · see citing works

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443 · see citing works

Capturing complex 3D tissue physiology in vitro

Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,274 · see citing works

Hyaluronic Acid Hydrogels for Biomedical Applications

Burdick, J. A., & Prestwich, G. D. (2011) · Advanced Materials · doi:10.1002/adma.201003963 · Cited by 2,152 · see citing works

A practical guide to hydrogels for cell culture

Caliari, S. R., & Burdick, J. A. (2016) · Nature Methods · doi:10.1038/nmeth.3839 · Cited by 2,075 · see citing works

Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives

Chen, X., Pradhan, T., Wang, F., Kim, J. S., & Yoon, J. (2011) · Chemical Reviews · doi:10.1021/cr200201z · Cited by 1,986 · see citing works

Designing Cell-Compatible Hydrogels for Biomedical Applications

Seliktar, D. (2012) · Science · doi:10.1126/science.1214804 · Cited by 1,930 · see citing works

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917 · see citing works

Modeling physiological events in 2D vs. 3D cell culture

Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849 · see citing works

Alginate Hydrogels as Biomaterials

Augst, A., Kong, H. J., & Mooney, D. J. (2006) · Macromolecular Bioscience · doi:10.1002/mabi.200600069 · Cited by 1,849 · see citing works

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760 · see citing works

Polymer brushes via surface-initiated controlled radical polymerization: synthesis, characterization, properties, and applications

Barbey, R., Lavanant, L., Paripovic, D., Schüwer, N., Sugnaux, C., Tugulu, S., & Klok, H.-A. (2009) · Chemical Reviews · doi:10.1021/cr900045a · Cited by 1,753 · see citing works

Modeling Tissue Morphogenesis and Cancer in 3D

Yamada, K. M., & Cukierman, E. (2007) · Cell · doi:10.1016/j.cell.2007.08.006 · Cited by 1,751 · see citing works

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748 · see citing works

Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications

Li, Y., Rodrigues, J., & Tomás, H. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15203c · Cited by 1,451 · see citing works

Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering

Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457 · see citing works

Design properties of hydrogel tissue-engineering scaffolds

Zhu, J., & Marchant, R. E. (2011) · Expert Review of Medical Devices · doi:10.1586/erd.11.27 · Cited by 1,434 · see citing works

Designing materials to direct stem-cell fate

Lütolf, M. P., Gilbert, P. M., & Blau, H. M. (2009) · Nature · doi:10.1038/nature08602 · Cited by 1,389 · see citing works

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

Lee, K., Silva, E. A., & Mooney, D. J. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0223 · Cited by 1,393 · see citing works

Nanotechnological strategies for engineering complex tissues

Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367 · see citing works

Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications

Nicodemus, G. D., & Bryant, S. J. (2008) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2007.0332 · Cited by 1,242 · see citing works

Supramolecular polymeric hydrogels

Appel, E. A., del Barrio, J., Loh, X. J., & Scherman, O. A. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35264h · Cited by 1,167 · see citing works

Biomimetic porous scaffolds for bone tissue engineering

Wu, S., Liu, X., Yeung, K., Liu, C., & Yang, X. (2014) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2014.04.001 · Cited by 1,163 · see citing works

Advancing biomaterials of human origin for tissue engineering

Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158 · see citing works

Printing and Prototyping of Tissues and Scaffolds

Derby, B. (2012) · Science · doi:10.1126/science.1226340 · Cited by 1,108 · see citing works

Vascularization is the key challenge in tissue engineering

Novosel, E. C., Kleinhans, C., & Kluger, P. J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.004 · Cited by 1,067 · see citing works

PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine

Lin, C., & Anseth, K. S. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9801-2 · Cited by 1,067 · see citing works

Hydrogel scaffolds for tissue engineering: Progress and challenges

El-sherbiny, I. M., & Yacoub, M. H. (2013) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2013.38 · Cited by 1,067 · see citing works

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg, M. S., Langer, R., & Jia, X. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207779996931 · Cited by 1,057 · see citing works

Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks

Griffin, D., Weaver, W., Scumpia, P. O., Carlo, D. D., & Segura, T. (2015) · Nature Materials · doi:10.1038/nmat4294 · Cited by 881 · see citing works

Cell–matrix adhesion

Berrier, A. L., & Yamada, K. M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21237 · Cited by 969 · see citing works

Sol–gel based materials for biomedical applications

Owens, G. J., Singh, R. K., Foroutan, F., Al-Qaysi, M., Han, C., Mahapatra, C., Kim, H., & Knowles, J. C. (2016) · Progress in Materials Science · doi:10.1016/j.pmatsci.2015.12.001 · Cited by 961 · see citing works

Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators

Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., et al. (2013) · ACS Nano · doi:10.1021/nn305559j · Cited by 946 · see citing works

Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells

Nayak, T. R., Andersen, H. L., Makam, V. S., Khaw, C., Bae, S., Xu, X., Ee, P. L. R., Ahn, J., Hong, B. H., Pastorin, G., et al. (2011) · ACS Nano · doi:10.1021/nn200500h · Cited by 917 · see citing works

Self-Healing Injectable Hydrogels for Tissue Regeneration

Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 923 · see citing works

Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

Naahidi, S., Jafari, M., Logan, M., Wang, Y., Yuan, Y., Bae, H., Dixon, B., & Chen, P. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.05.006 · Cited by 910 · see citing works

Engineered biomaterials for in situ tissue regeneration

Gaharwar, A. K., Singh, I., & Khademhosseini, A. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0209-x · Cited by 872 · see citing works

3D printing of hydrogels: Rational design strategies and emerging biomedical applications

Li, J., Wu, C., Chu, P. K.-H., & Gelinsky, M. (2020) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2020.100543 · Cited by 867 · see citing works

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

DeForest, C. A., Polizzotti, B. D., & Anseth, K. S. (2009) · Nature Materials · doi:10.1038/nmat2473 · Cited by 847 · see citing works

Extracellular matrix-based materials for regenerative medicine

Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works

Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825 · see citing works

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter, J. R., Ruckh, T. T., & Popat, K. C. (2009) · Biotechnology Progress · doi:10.1002/btpr.246 · Cited by 812 · see citing works

Rheological properties of peptide-based hydrogels for biomedical and other applications

Yan, C., & Pochan, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b919449p · Cited by 805 · see citing works

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels

Chen, Y., Lin, R., Qi, H., Yang, Y., Bae, H., Melero‐Martin, J. M., & Khademhosseini, A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101662 · Cited by 782 · see citing works

Hydrogels in sensing applications

Buenger, D., Topuz, F., & Gröll, J. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.09.001 · Cited by 763 · see citing works

Biofabrication strategies for 3D in vitro models and regenerative medicine

Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753 · see citing works

Graphene-based materials for tissue engineering

Shin, S. R., Li, Y.-C., Jang, H. L., Khoshakhlagh, P., Akbari, M., Nasajpour, A., Zhang, Y. S., Tamayol, A., & Khademhosseini, A. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.03.007 · Cited by 725 · see citing works

Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering

Wang, H., & Heilshorn, S. C. (2015) · Advanced Materials · doi:10.1002/adma.201501558 · Cited by 722 · see citing works

Strategies and Molecular Design Criteria for 3D Printable Hydrogels

Jüngst, T., Smolan, W., Schacht, K., Scheibel, T., & Gröll, J. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00303 · Cited by 716 · see citing works

Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues

McKee, C. T., Last, J. A., Russell, P., & Murphy, C. J. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0520 · Cited by 711 · see citing works

Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering

Lee, S., & Shin, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.016 · Cited by 707 · see citing works

The myofibroblast: Paradigm for a mechanically active cell

Hinz, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 695 · see citing works

Nonthermal Plasma Technology as a Versatile Strategy for Polymeric Biomaterials Surface Modification: A Review

Desmet, T., Morent, R., Geyter, N. D., Leys, C., Schacht, E. H., & Dubruel, P. (2009) · Biomacromolecules · doi:10.1021/bm900186s · Cited by 691 · see citing works

Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells

Zhou, M., Smith, A. M., Das, A. K., Hodson, N. W., Collins, R. F., Ulijn, R. V., & Gough, J. E. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.010 · Cited by 673 · see citing works

Calcium phosphate coatings for bio-implant applications: Materials, performance factors, and methodologies

Paital, S. R., & Dahotre, N. B. (2009) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2009.05.001 · Cited by 673 · see citing works

Stimuli-responsive surfaces for bio-applications

Mendes, P. M. (2008) · Chemical Society Reviews · doi:10.1039/b714635n · Cited by 664 · see citing works

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

Sabeh, F., Shimizu‐Hirota, R., & Weiss, S. J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807195 · Cited by 658 · see citing works

Toward delivery of multiple growth factors in tissue engineering

Chen, F., Zhang, M., & Wu, Z. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.053 · Cited by 655 · see citing works

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

Legant, W. R., Miller, J. S., Blakely, B. L., Cohen, D. M., Genin, G. M., & Chen, C. S. (2010) · Nature Methods · doi:10.1038/nmeth.1531 · Cited by 647 · see citing works

Two‐Dimensional Fluorinated Graphene: Synthesis, Structures, Properties and Applications

Feng, W., Peng, L., Feng, Y., & Yu, H. (2016) · Advanced Science · doi:10.1002/advs.201500413 · Cited by 642 · see citing works

Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography

Gauvin, R., Chen, Y.-C., Lee, J. W., Soman, P., Zorlutuna, P., Nichol, J. W., Bae, H., Chen, S., & Khademhosseini, A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.048 · Cited by 641 · see citing works

Injectable matrices and scaffolds for drug delivery in tissue engineering

Kretlow, J. D., Klouda, L., & Mikos, A. G. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.013 · Cited by 629 · see citing works

Physicochemical regulation of biofilm formation

Renner, L. D., & Weibel, D. B. (2011) · MRS Bulletin · doi:10.1557/mrs.2011.65 · Cited by 624 · see citing works

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji, S., Kwon, I. K., & Park, K. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.018 · Cited by 615 · see citing works

Surface-Initiated Polymer Brushes in the Biomedical Field: Applications in Membrane Science, Biosensing, Cell Culture, Regenerative Medicine and Antibacterial Coatings

Krishnamoorthy, M., Hakobyan, S., Ramstedt, M., & Gautrot, J. E. (2014) · Chemical Reviews · doi:10.1021/cr500252u · Cited by 606 · see citing works

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

Loessner, D., Stok, K. S., Lutolf, M. P., Hutmacher, D. W., Clements, J. A., & Rizzi, S. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.064 · Cited by 602 · see citing works

Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks

Xu, X., Jha, A. K., Harrington, D. A., Farach‐Carson, M. C., & Jia, X. (2012) · Soft Matter · doi:10.1039/c2sm06463d · Cited by 601 · see citing works

Interstitial flow and its effects in soft tissues.

Swartz, M., & Fleury, M. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.151850 · Cited by 627 · see citing works

Self-assembled hydrogels utilizing polymer–nanoparticle interactions

Appel, E. A., Tibbitt, M. W., Webber, M. J., Mattix, B. A., Omid Veiseh, A., & Langer, R. (2015) · Nature Communications · doi:10.1038/ncomms7295 · Cited by 574 · see citing works

Elastomeric biomaterials for tissue engineering

Chen, Q., Liang, S., & Thouas, G. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.05.003 · Cited by 564 · see citing works

Silk fibroin as a vehicle for drug delivery applications

Wenk, E., Merkle, H. P., & Meinel, L. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.007 · Cited by 560 · see citing works

Synthetic polypeptides for biomedical applications

Deming, T. J. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.010 · Cited by 555 · see citing works

3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages

Habanjar, O., Diab‐Assaf, M., Caldefie‐Chezet, F., & Delort, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212200 · Cited by 556 · see citing works

Probing the role of multicellular organization in three-dimensional microenvironments

Albrecht, D. R., Underhill, G. H., Wassermann, T., Sah, R. L., & Bhatia, S. N. (2006) · Nature Methods · doi:10.1038/nmeth873 · Cited by 553 · see citing works

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

Kim, J., Li, A. W., Choi, Y., Lewin, S. A., Verbeke, C. S., Dranoff, G., & Mooney, D. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3071 · Cited by 541 · see citing works

Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery

Phelps, E. A., Enemchukwu, N. O., Fiore, V. F., Sy, J. C., Murthy, N., Sulchek, T., Barker, T. H., & Garcı́a, A. J. (2011) · Advanced Materials · doi:10.1002/adma.201103574 · Cited by 541 · see citing works

Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering

Liu, X., Callahan, L. A. S., Hu, J., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.068 · Cited by 540 · see citing works

Tissue Engineering for Cutaneous Wounds

Clark, R. A. F., Ghosh, K., & Tonnesen, M. G. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700715 · Cited by 540 · see citing works

Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering

Singelyn, J. M., DeQuach, J. A., Seif-Naraghi, S. B., Littlefield, R. B., Schup-Magoffin, P. J., & Christman, K. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.045 · Cited by 535 · see citing works

In situ-forming injectable hydrogels for regenerative medicine

Yang, J., Yeom, J., Hwang, B. W., Hoffman, A. S., & Hahn, S. K. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.006 · Cited by 534 · see citing works

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

Spicer, C. D. (2019) · Polymer Chemistry · doi:10.1039/c9py01021a · Cited by 530 · see citing works

A self-assembling peptide acting as an immune adjuvant

Rudra, J. S., Tian, Y. F., Jung, J. P., & Collier, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912124107 · Cited by 523 · see citing works

Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells

Kim, J., Kim, I. S., Cho, T. H., Lee, K. B., Hwang, S. J., Tae, G., Noh, I., Lee, S. H., Park, Y., & Sun, K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.050 · Cited by 520 · see citing works

Bioinspired fabrication of high strength hydrogels from non-covalent interactions

Wang, W., Zhang, Y., & Liu, W. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.04.001 · Cited by 518 · see citing works

The Potential of Cellulose Nanocrystals in Tissue Engineering Strategies

Domingues, R. M. A., Gomes, M. E., & Reis, R. L. (2014) · Biomacromolecules · doi:10.1021/bm500524s · Cited by 510 · see citing works

Design principles of food gels

Cao, Y., & Mezzenga, R. (2020) · Nature Food · doi:10.1038/s43016-019-0009-x · Cited by 510 · see citing works

Extracellular matrix-based biomaterial scaffolds and the host response

Aamodt, J. M., & Grainger, D. W. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.003 · Cited by 509 · see citing works

In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy

Xu, L., Pan, F., Yu, G., Yang, L. J., Zhang, E., & Yang, K. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.001 · Cited by 505 · see citing works

3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 504 · see citing works

Rational design of hydrogels for tissue engineering: Impact of physical factors on cell behavior

Brandl, F., Sommer, F., & Göpferich, A. M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.017 · Cited by 496 · see citing works

Mimicking biological functionality with polymers for biomedical applications

Green, J. J., & Elisseeff, J. H. (2016) · Nature · doi:10.1038/nature21005 · Cited by 494 · see citing works

Electrospun materials as potential platforms for bone tissue engineering

Jang, J., Castaño, Ó., & Kim, H. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.008 · Cited by 493 · see citing works

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination

Kloxin, A. M., Kloxin, C. J., Bowman, C. N., & Anseth, K. S. (2010) · Advanced Materials · doi:10.1002/adma.200904179 · Cited by 477 · see citing works

Synthetic Biomaterials as Cell-Responsive Artificial Extracellular Matrices

Lütolf, M. P., & Hubbell, J. A. (2008) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781848161832_0013 · Cited by 2 · see citing works

Synthetic Extracellular Microenvironment for Modulating Stem Cell Behaviors

Chandra, P. K., & Lee, S. J. (2015) · Biomarker Insights · doi:10.4137/bmi.s20057 · Cited by 27 · see citing works

3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate

Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 504 · see citing works

Engineering ECM signals into biomaterials

Wade, R. J., & Burdick, J. A. (2012) · Materials Today · doi:10.1016/s1369-7021(12)70197-9 · Cited by 209 · see citing works

Design of three‐dimensional biomimetic scaffolds

Owen, S. C., & Shoichet, M. S. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32834 · Cited by 205 · see citing works