The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation and retrieval of circulating tumor cells using centrifugal forces
Open accessAbstract
Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral microchannel with inherent centrifugal forces for continuous, size-based separation of CTCs from blood (Dean Flow Fractionation (DFF)) which facilitates easy coupling with conventional downstream biological assays. Device performance was optimized using cancer cell lines (> 85% recovery), followed by clinical validation with positive CTCs enumeration in all samples from patients with metastatic lung cancer (n = 20; 5-88 CTCs per mL). The presence of CD133⁺ cells, a phenotypic marker characteristic of stem-like behavior in lung cancer cells was also identified in the isolated subpopulation of CTCs. The spiral biochip identifies and addresses key challenges of the next generation CTCs isolation assay including antibody independent isolation, high sensitivity and throughput (3 mL/hr); and single-step retrieval of viable CTCs.
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Cites
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Maheswaran, S., Sequist, L. V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C. V., Inserra, E., Diederichs, S., Iafrate, A. J., Bell, D. W., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800668 · Cited by 1,617
Cited by
Amini, H., Lee, W., & Di Carlo, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00128a · Cited by 722
Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
Boussommier-Calleja, A., Li, R., Chen, M. B., Wong, S. C., & Kamm, R. D. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2015.12.003 · Cited by 224
“Eventually, different components could be integrated in one microfluidic chip for increased throughput and automation, e.g. isolation of CTCs followed by diagnostic tests in a single microfluidic set-up.”
BackgroundExpansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model
Zhang, Z., Shiratsuchi, H., Lin, J., Chen, G., Reddy, R. M., Azizi, E., Fouladdel, S., Chang, A. C., Lin, L., Jiang, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2592 · Cited by 207
Khoo, B. L., Grenci, G., Jing, T., Lim, Y. B., Lee, S. C., Thiery, J. P., Han, J., & Lim, C. T. (2016) · Science Advances · doi:10.1126/sciadv.1600274 · Cited by 147
Self-citationAbdulla, A., Liu, W., Gholamipour-Shirazi, A., Sun, J., & Ding, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04210 · Cited by 131
Metadata
- Authors
- Hou, H. W., Warkiani, M. E., Khoo, B. L., Li, Z. R., Soo, R. A., Tan, D. S.-W., Lim, W.-T., Han, J., Bhagat, A. A. S., & Lim, C. T.
- Venue
- Scientific Reports
- Published
- 2013-02-12
- Volume
- 3
- Issue
- 1
- Pages
- 1259-1259
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2115158793
- Cited by
- 736
- References
- 1
- FWCI
- 40.74
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hou, H. W., Warkiani, M. E., Khoo, B. L., Li, Z. R., Soo, R. A., Tan, D. S.-W., Lim, W.-T., Han, J., Bhagat, A. A. S., & Lim, C. T. (2013). Isolation and retrieval of circulating tumor cells using centrifugal forces. Scientific Reports. https://doi.org/10.1038/srep01259
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