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Cited by 182

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Ultrasound and pH Dually Responsive Polymer Vesicles for Anticancer Drug Delivery

Open access
Chen, Wenqin, Du, Jianzhong·2013·Scientific Reports
DOI 10.1038/srep02162
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Abstract

Recently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative diseases. However, the evolution of stimuli-responsive vesicles from bench to bedside still seems far away for the limitations of current stimuli forms such as temperature, light, redox, etc. Since ultrasound combined with chemotherapy has been widely used in tumor treatment and the pH in tumor tissues is relatively low, we designed herein a novel polymer vesicle that respond to both physical (ultrasound) and chemical (pH) stimuli based on a PEO-b-P(DEA-stat-TMA) block copolymer, where PEO is short for poly(ethylene oxide), DEA for 2-(diethylamino)ethyl methacrylate and TMA for (2-tetrahydrofuranyloxy)ethyl methacrylate. These dually responsive vesicles show noncytotoxicity below 250 μg/mL and can encapsulate anticancer drugs, exhibiting retarded release profile and controllable release rate when subjected to ultrasound radiation or varying pH in tris buffer at 37°C.

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Metadata

Authors
Chen, W., & Du, J.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2013-07-08
Volume
3
Issue
1
Pages
2162-2162
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep02162
OpenAlex
W2053678405
Cited by
182
References
1
FWCI
6.71
Type
journal article
Language
en
Open access
gold

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