Drug delivery in pluronic micelles: Effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Open accessAbstract
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20-100 kHz). Even a short (15-30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed.
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The study showed increased DOX release under high-frequency ultrasound.
“The study showed increased DOX release under high-frequency ultrasound [206].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [206]
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- Authors
- Marin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y.
- Affiliations
- University of Utah (US)
- Brigham Young University (US)
- Corresponding author
- Rapoport, Natalya Y
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 84
- Issue
- 1-2
- Pages
- 39-47
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W1969929756
- Cited by
- 213
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 21 · 2012: 17
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- DSpace at AUS (American University of Sharjah) (acceptedVersion)
- DSpace at AUS (American University of Sharjah) (submittedVersion)
- Funders
- National Institutes of Health (5r01ca076562-03)
- National Cancer Institute (CA 76562)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Ultrasound and Cavitation Phenomena
- Keywords
- Pluronic micelles, high-frequency ultrasound, doxorubicin, drug release, intracellular drug uptake, cavitation, multidrug resistance, ovarian carcinoma, breast cancer, HL-60 cells, MCF-7 cells, power density
- MeSH terms
- Algorithms, Antibiotics, Antineoplastic, Breast Neoplasms, Doxorubicin, Electron Spin Resonance Spectroscopy, Excipients, Female, Flow Cytometry, Humans, Micelles, Ovarian Neoplasms, Spectrometry, Fluorescence, Surface Properties, Ultrasonics, Leukemia, Promyelocytic, Acute, Drug Delivery Systems, HL-60 Cells, Poloxamer
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