The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement
Open accessAbstract
Detecting and quantifying biomarkers and viruses in biological samples have broad applications in early disease diagnosis and treatment monitoring. We have demonstrated a label-free optical sensing mechanism using nanostructured photonic crystals (PC) to capture and quantify intact viruses (HIV-1) from biologically relevant samples. The nanostructured surface of the PC biosensor resonantly reflects a narrow wavelength band during illumination with a broadband light source. Surface-adsorbed biotarget induces a shift in the resonant Peak Wavelength Value (PWV) that is detectable with <10 pm wavelength resolution, enabling detection of both biomolecular layers and small number of viruses that sparsely populate the transducer surface. We have successfully captured and detected HIV-1 in serum and phosphate buffered saline (PBS) samples with viral loads ranging from 10(4) to 10(8) copies/mL. The surface density of immobilized biomolecular layers used in the sensor functionalization process, including 3-mercaptopropyltrimethoxysilane (3-MPS), N-gamma-Maleimidobutyryl-oxysuccinimide ester (GMBS), NeutrAvidin, anti-gp120, and bovine serum albumin (BSA) were also quantified by the PC biosensor.
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Chaotic Mixer for Microchannels
Stroock, A. D., Dertinger, S. K. W., Ajdari, A., Mezić, I., Stone, H. A., & Whitesides, G. M. (2002) · Science · doi:10.1126/science.1066238 · Cited by 3,435
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Metasurface Micro/Nano-Optical Sensors: Principles and Applications
Qin, J., Jiang, S., Wang, Z., Cheng, X., Li, B., Shi, Y., Tsai, D. P., Liu, A. Q., Huang, W., & Zhu, W. (2022) · ACS Nano · doi:10.1021/acsnano.2c03310 · Cited by 359
Optical biosensors: A decade in review
Singh, A. K., Mittal, S., Das, M., Saharia, A., & Tiwari, M. (2023) · Alexandria Engineering Journal · doi:10.1016/j.aej.2022.12.040 · Cited by 292
Metadata
- Authors
- Shafiee, H., Lidstone, E. A., Jahangir, M., Inci, F., Hanhauser, E., Henrich, T. J., Kuritzkes, D. R., Cunningham, B. T., & Demirci, U.
- Venue
- Scientific Reports
- Published
- 2014-02-28
- Volume
- 4
- Issue
- 1
- Pages
- 4116-4116
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2120938435
- Cited by
- 190
- References
- 1
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shafiee, H., Lidstone, E. A., Jahangir, M., Inci, F., Hanhauser, E., Henrich, T. J., Kuritzkes, D. R., Cunningham, B. T., & Demirci, U. (2014). Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement. Scientific Reports. https://doi.org/10.1038/srep04116
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