Optical biosensors: A decade in review

Singh, Amit Kumar; Mittal, Shweta; Das, Mangal; Saharia, Ankur; Tiwari, Manish

doi:10.1016/j.aej.2022.12.040

Cited by 292Advanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionAnalytical Chemistry and Sensors

Optical biosensors: A decade in review

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Singh, Amit Kumar, Mittal, Shweta, Das, Mangal, Saharia, Ankur, Tiwari, Manish·2023·Alexandria Engineering Journal

DOI 10.1016/j.aej.2022.12.040

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Abstract

Miniaturized, specific, rapid response and economical biosensors are finding applications in biotechnology, environmental studies, agriculture, food inspection and safety, disease diagnosis and medical utilities. Of the many categories of biosensors, optical biosensors have brought about an extra edge in sensing applications due to their selective, rapid and extremely sensitive measurements. Biosensors are analytical tools used to detect specific analytes such as cholesterol, urea, etc. having biomolecules such as nucleic acids, proteins, carbohydrates as key element for detecting these analytes along with a transducer and a data analysis and visualization tool. In case of optical biosensors the analyte is detected using light with either label based or label free techniques. In this paper some of the marked advances in the last decade in the field of optical biosensors have been reviewed with an emphasis on their fabrication approaches and growing application areas. Along with some of the carefully selected article on new developments in optical biosensors through the last decade, a brief historical review of optical biosensors since the breakthrough in optical biosensors in 1970s has also been presented. Another focus of the current review is the classification of biosensors, typical structures along with emerging developments in optical biosensing that are likely to impact the current decade. Major application areas and emerging applications through the last decade have been outlined to present a clear picture on the versatility of optical biosensors. Finally, the review also considers the challenges and future of emerging optical biosensing technologies in the current decade.

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Label-based optical techniques are colorimetric or fluorometric methods that have demonstrated great promise for monitoring metabolites, glucose, and other biomarkers in sweat, tears, or interstitial fluid.
“Label-based optical techniques are colorimetric or fluorometric methods [172] which have demonstrated great promise for monitoring of metabolites, glucose, and other biomarkers in sweat, tears, or interstitial fluid, providing valuable insights for disease management and preventive healthcare [173,174].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [172]
Integration of these materials into flexible substrates and microfluidic devices has facilitated the development of wearable devices that are lightweight, conformable, and comfortable for long-term use.
“Integration of these materials into flexible substrates and microfluidic devices has facilitated the development of wearable devices that are lightweight, conformable, and comfortable for long-term use [172].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [172]

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Authors: Singh, A. K., Mittal, S., Das, M., Saharia, A., & Tiwari, M.
Affiliations: Manipal University Jaipur (IN)
Vellore Institute of Technology University (IN)
Corresponding author: Tiwari, Manish
ORCID: Singh, Amit Kumar
Das, Mangal
Saharia, Ankur
Venue: Alexandria Engineering Journal
Publisher: Elsevier BV
Published: 2023-03
Volume: 67
Pages: 673-691
ISSN: 1110-0168 (ISSN-L)
DOI: 10.1016/j.aej.2022.12.040
OpenAlex: W4320474624
Cited by: 292
References: 266
Citations by year: 2026: 64 · 2025: 108 · 2024: 87 · 2023: 33
FWCI: 26.02
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Alexandria Engineering Journal (publishedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
Keywords: optical biosensors, biosensor fabrication, label-free detection, biosensor classification, biosensor applications, biosensor miniaturization, disease diagnosis, food safety, environmental monitoring

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Optical biosensors: A decade in review

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