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Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo
Open accessAbstract
To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual micron-sized particles deposited into the airways of live mice. The aim of this study was to image changes in MCT produced by a rehydrating treatment based on hypertonic saline (HS), a current CF clinical treatment. Live mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic saline; or no treatment, using a nebuliser integrated within a small-animal ventilator circuit. Marker particle motion was tracked for 20 minutes using PCXI. There were statistically significant increases in MCT in the isotonic and HS-P308 groups. The ability to quantify in vivo changes in MCT may have utility in pre-clinical research studies designed to bring new genetic and pharmaceutical treatments for respiratory diseases into clinical trials.
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Metadata
- Authors
- Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N. R., Stahr, C. S., Boucher, R. C., Fouras, A., & Parsons, D. W.
- Venue
- Scientific Reports
- Published
- 2014-07-16
- Volume
- 4
- Issue
- 1
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2602364388
- Cited by
- 733
- References
- 0
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo. https://app.cochat.ai/papers/10.1038/srep05361
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- Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N. R., Stahr, C. S., Boucher, R. C., Fouras, A., & Parsons, D. W. (2014). Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo. Scientific Reports. https://doi.org/10.1038/srep05361
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