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Cited by 82Lipid metabolism and biosynthesisNeurobiology and Insect Physiology ResearchCancer, Lipids, and Metabolism

Glial β-oxidation regulates Drosophila energy metabolism

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Schulz, Joachim G., Laranjeira, Antonio, Van Huffel, Leen, Gärtner, Annette, Vilain, Sven, Bastianen, Jarl, Van Veldhoven, Paul P., Dotti, Carlos G.·2015·Scientific Reports
DOI 10.1038/srep07805PMC PMC4295106
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Abstract

The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we here show in vivo that loss of the Drosophila carnitine palmitoyltransferase 2 (CPT2), an enzyme required for mitochondrial β-oxidation of long-chain fatty acids as substrates for energy production, results in the accumulation of triacylglyceride-filled lipid droplets in adult Drosophila brain but not in obesity. CPT2 rescue in glial cells alone is sufficient to restore triacylglyceride homeostasis, and we suggest that this is mediated by the release of ketone bodies from the rescued glial cells. These results demonstrate that the adult brain is able to catabolize fatty acids for cellular energy production.

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  • Loss of a mitochondrial fatty acid importer leads to lipid droplet accumulation in the Drosophila brain.

    “These findings are in line with a previous report in Drosophila that loss of a mitochondrial FA importer leads to LD accumulation in the brain (Schulz et al., 2015).”

    From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Schulz et al., 2015

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Authors
Schulz, J. G., Laranjeira, A., Van Huffel, L., Gärtner, A., Vilain, S., Bastianen, J., Van Veldhoven, P. P., & Dotti, C. G.
Affiliations
  • KU Leuven (BE)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
  • Schulz, Joachim G.
  • Dotti, Carlos G.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2015-01-15
Volume
5
Issue
1
Pages
7805-7805
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep07805
PMC
PMC4295106
OpenAlex
W2053363717
Cited by
82
References
1
Citations by year
2026: 6 · 2025: 8 · 2024: 12 · 2023: 10 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 1 · 2015: 2
FWCI
3.38
Type
journal article
Language
en
Update notices
addendum (2020-07-31)
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
Funders
  • Fonds Wetenschappelijk Onderzoek (FWO G 0.666.10N)
  • Ministerio de Economía y Competitividad (SAF2013-45392, CSD-2010-00045)
  • KU Leuven
  • Vlaamse regering
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
brain energy metabolism, CPT2, lipid droplets, ketone bodies, Drosophila brain, glial cells
MeSH terms
Aging, Amino Acid Sequence, Animals, Brain, Carnitine O-Palmitoyltransferase, Drosophila melanogaster, Energy Metabolism, Homeostasis, Humans, Larva, Molecular Sequence Data, Mutation, Neuroglia, Obesity, Oxidation-Reduction, Phospholipids, RNA, Messenger, Triglycerides, Survival Analysis, Sequence Alignment, Drosophila Proteins, Lipid Metabolism, Lipid Droplets

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