Starving Neurons Show Sex Difference in Autophagy

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Brewer, G. J., Torricelli, J. R., Evege, E. K., & Price, P. J. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350513 · Cited by 2,094 · see citing works

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075 · see citing works

A ubiquitin-like system mediates protein lipidation

Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., et al. (2000) · Nature · doi:10.1038/35044114 · Cited by 2,064 · see citing works

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

Seglen, P. O., & Gordon, P. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.1889 · Cited by 1,360 · see citing works

Molecular dissection of autophagy: two ubiquitin-like systems

Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240 · see citing works

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108 · see citing works

Methods for monitoring autophagy

Mizushima, N. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.005 · Cited by 884 · see citing works

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070876 · Cited by 486 · see citing works

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death.

Zhu, J.-H., Horbinski, C., Guo, F.-L., Watkins, S. C., Uchiyama, Y., & Chu, C. T. (2007) · American Journal of Pathology · doi:10.2353/ajpath.2007.060524 · Cited by 469 · see citing works

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

Akbar, M. D., Calderón, F. H., Wen, Z., & Kim, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502903102 · Cited by 466 · see citing works

Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway

Du, L., Bayır, H., Lai, Y., Zhang, X., Kochanek, P. M., Watkins, S. C., Graham, S. H., & Clark, R. S. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405461200 · Cited by 351 · see citing works

Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

Zeng, X., Overmeyer, J. H., & Maltese, W. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02735 · Cited by 331 · see citing works

Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients

Wolf, I., Sadetzki, S., Kanety, H., Kundel, Y., Pariente, C., Epstein, N., Oberman, B., Catane, R., Kaufman, B., & Shimon, I. (2006) · Cancer · doi:10.1002/cncr.21690 · Cited by 184 · see citing works

Direct qualitative analysis of triacylglycerols by electrospray mass spectrometry using a linear ion trap

McAnoy, A. M., Wu, C. C., & Murphy, R. C. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.04.017 · Cited by 173 · see citing works

Autophagy is Increased after Traumatic Brain Injury in Mice and is Partially Inhibited by the Antioxidant γ-glutamylcysteinyl Ethyl Ester

Lai, Y.-C., Hickey, R., Chen, Y.-M., Bayır, H., Sullivan, M. L. G., Chu, C. T., Kochanek, P., Dixon, C., Jenkins, L., Graham, S., et al. (2008) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/sj.jcbfm.9600551 · Cited by 171 · see citing works

Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets

Bakewell, L., Burdge, G. C., & Calder, P. C. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061801 · Cited by 165 · see citing works

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

Clark, R. S. B., Bayir, H., Chu, C. T., Alber, S. M., Kochanek, P. M., & Watkins, S. C. (2008) · Autophagy · doi:10.4161/auto.5173 · Cited by 148 · see citing works

Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons

Patil, S. P., & Chan, C. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.003 · Cited by 138 · see citing works

Changes in Autophagy after Traumatic Brain Injury

Liu, C. L., Chen, S., Dietrich, D., & Hu, B.-R. (2008) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/sj.jcbfm.9600587 · Cited by 137 · see citing works

3‐Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism

P., L. H., PLOMP, P. J. A. M., Wolvetang, E. J., KERKHOF, C., & Meijer, A. J. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14200.x · Cited by 136 · see citing works

Palmitic and stearic fatty acids induce caspase‐dependent and ‐independent cell death in nerve growth factor differentiated PC12 cells

Ulloth, J. E., Casiano, C. A., & León, M. D. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01571.x · Cited by 135 · see citing works

The response of the sexes to nutritional stress

Widdowson, E. M. (1976) · Proceedings of the Nutrition Society · doi:10.1079/pns19760030 · Cited by 115 · see citing works

Gender and energy balance: Sex differences in adaptations for feast and famine

Hoyenga, K. B., & Hoyenga, K. T. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90153-6 · Cited by 113 · see citing works

Group IVA Phospholipase A2 Is Necessary for the Biogenesis of Lipid Droplets

Gubern, A., Casas, J., Barceló-Torns, M., Barneda, D., de la Rosa, X., Masgrau, R., Picatoste, F., Balsinde, J., Balboa, M. A., & Claro, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800696200 · Cited by 110 · see citing works

Inhibition of human platelet phospholipase A2 activity by unsaturated fatty acids.

Ballou, L. R., & Cheung, W. Y. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.371 · Cited by 107 · see citing works

Solution Structure of Microtubule-associated Protein Light Chain 3 and Identification of Its Functional Subdomains

Kouno, T., Mizuguchi, M., Tanida, I., Ueno, T., Kanematsu, T., Mori, Y., Shinoda, H., Hirata, M., Kominami, E., & Kawano, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413565200 · Cited by 103 · see citing works

Hippocampal volume and cognitive function in anorexia nervosa

Connan, F., Murphy, F., Connor, S. E. J., Rich, P., Murphy, T. L., Bara-Carill, N., Landau, S., Krljes, S., Ng, V., Williams, S., et al. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.10.006 · Cited by 103 · see citing works

Starving the brain: Structural abnormalities and cognitive impairment in adolescents with anorexia nervosa

Katzman, D. K., Christensen, B. K., Young, A., & Zipursky, R. B. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.22263 · Cited by 90 · see citing works

Gender differences in the regulation of amino acid metabolism

Lamont, L. S., McCullough, A. J., & Kalhan, S. C. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01028.2002 · Cited by 78 · see citing works

The neurotrophic effect of oleic acid includes dendritic differentiation and the expression of the neuronal basic helix‐loop‐helix transcription factor NeuroD2

Rodríguez‐Rodríguez, R. A., Tabernero, A., Velasco, A. L., Lavado, E. M., & Medina, J. M. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02262.x · Cited by 64 · see citing works

Cytoplasmic Lipid Droplets

Fujimoto, T., & Ohsaki, Y. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.010 · Cited by 64 · see citing works

Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss

Niskanen, L., Haffner, S. M., Karhunen, L., Turpeinen, A., Miettinen, H. M., & Uusitupa, M. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370061 · Cited by 64 · see citing works

Neurological complications of prolonged hunger strike

Başoğlu, M., Yetımalar, Y., Gürgör, N., Satıcı, S. B., Kurt, T., Seçıl, Y., & Yeniocak, A. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01531.x · Cited by 50 · see citing works

Effects of docosapentaenoic acid on neuronal apoptosis

Kim, H., Akbar, M. D., & Lau, A. O. T. (2003) · Lipids · doi:10.1007/s11745-003-1083-z · Cited by 41 · see citing works

Localization of products of endogenous proteolysis in lysosomes of perfused rat liver

Neely, A. N., & Mortimore, G. E. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(74)80033-1 · Cited by 38 · see citing works

The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of brain dysfunction

Hopkins, R. O., Ely, E. W., & Jackson, J. C. (2007) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e3282efd19c · Cited by 22 · see citing works

Evidence for two distinct lysophospholipase activities that degrade lysophosphatidylcholine and lysophosphatidic acid in neuronal nuclei of cerebral cortex

Baker, R. R., & Chang, H.-Y. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00057-8 · Cited by 18 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Mechanistic Pathways of Sex Differences in Cardiovascular Disease

Regitz‐Zagrosek, V., & Kararigas, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 738 · see citing works

Autophagy Failure in Alzheimer's Disease – Locating the Primary Defect

Nixon, R., & Yang, D.-S. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.021 · Cited by 634 · see citing works

Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know

Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533 · see citing works

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

Zhang, X., Yan, H., Yuan, Y., Gao, J., Shen, Z., Cheng, Y., Shen, Y., Wang, R.-R., Wang, X., Hu, W.-W., et al. (2013) · Autophagy · doi:10.4161/auto.25132 · Cited by 510 · see citing works

Not Just Fat: The Structure and Function of the Lipid DropletPreprint

Fujimoto, T., & Parton, R. G. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004838 · Cited by 485 · see citing works

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

Pol, A., Gross, S. P., & Parton, R. G. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201311051 · Cited by 466 · see citing works

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441 · see citing works

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Qi, G., Mi, Y., Shi, X., Gu, H., Brinton, R. D., & Yin, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108572 · Cited by 379 · see citing works

Sex differences in cancer mechanisms

Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. I., et al. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00291-x · Cited by 370 · see citing works

Mitochondria: A central target for sex differences in pathologies

Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371 · see citing works

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

Petan, T., Jovičić, E. J., & Jusović, M. (2018) · Molecules · doi:10.3390/molecules23081941 · Cited by 369 · see citing works

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

Millar, L., Shi, L., Hoerder-Suabedissen, A., & Molnár, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00078 · Cited by 323 · see citing works

Short-term fasting induces profound neuronal autophagy

Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., & Kiosses, W. B. (2010) · Autophagy · doi:10.4161/auto.6.6.12376 · Cited by 312 · see citing works

Lipid Droplets and the Management of Cellular Stress.

Jovičić, E. J., & Petan, T. (2019) · Europe PMC (PubMed Central) · Cited by 309 · see citing works

Sex differences in stroke: Challenges and opportunities

Bushnell, C., Chaturvedi, S., Gage, K. R., Herson, P. S., Hurn, P. D., Jiménez, M. C., Kittner, S. J., Madsen, T. E., McCullough, L. D., McDermott, M., et al. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18793324 · Cited by 309 · see citing works

Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis

Sugimoto, C. R., Ahn, Y., Smith, E. M. R., Macaluso, B., & Larivière, V. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32995-7 · Cited by 309 · see citing works

Treatment advances in neonatal neuroprotection and neurointensive care

Johnston, M. V., Fatemi, A. S., Wilson, M. A., & Northington, F. J. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70016-3 · Cited by 279 · see citing works

Lipid droplets in neurodegenerative disorders

Farmer, B. C., Walsh, A. E., Kluemper, J. C., & Johnson, L. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00742 · Cited by 270 · see citing works

Hypoxic-Ischemic Encephalopathy in the Term Infant

Fatemi, A. S., Wilson, M. A., & Johnston, M. V. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.07.011 · Cited by 267 · see citing works

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

Zhang, X., Yuan, Y., Jiang, L., Zhang, J., Gao, J., Shen, Z., Zheng, Y., Deng, T., Yan, H., Li, W., et al. (2014) · Autophagy · doi:10.4161/auto.32136 · Cited by 259 · see citing works

The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Vegeto, E., Villa, A. M., Torre, S. D., Crippa, V., Rusmini, P., Cristofani, R., Galbiati, M., Maggi, A. C., & Poletti, A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz005 · Cited by 231 · see citing works

Mitophagy and Parkinson's disease: The PINK1–parkin link

Deas, E., Wood, N. W., & Plun‐Favreau, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.08.007 · Cited by 222 · see citing works

Lipid droplets: size matters

Suzuki, M., Shinohara, Y., Ohsaki, Y., & Fujimoto, T. (2011) · Microscopy · doi:10.1093/jmicro/dfr016 · Cited by 196 · see citing works

Sex differences in mitochondrial (dys)function: Implications for neuroprotection

Demarest, T. G., & McCarthy, M. M. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9583-7 · Cited by 192 · see citing works

Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling

Seo, J. H., Maki, T., Maeda, M., Miyamoto, N., Liang, A. C., Hayakawa, K., Pham, L. D., Suwa, F., Taguchi, A., Matsuyama, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103174 · Cited by 181 · see citing works

The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases

Yue, Z., Friedman, L. G., Komatsu, M., & Tanaka, K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.01.016 · Cited by 173 · see citing works

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.255 · Cited by 163 · see citing works

Cell Survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-Oxidation of Fatty Acids*

Cabodevilla, A. G., Sánchez-Caballero, L., Nintou, E., Boiadjieva, V. G., Picatoste, F., Gubern, A., & Claro, E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.466656 · Cited by 154 · see citing works

Nutrition and human health from a sex–gender perspective

Marino, M., Masella, R., Bulzomi, P., Campesi, I., Malorni, W., & Franconi, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.02.001 · Cited by 152 · see citing works

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 153 · see citing works

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

Haspel, J., Shaik, R. S., Ifedigbo, E., Nakahira, K., Dolinay, T., Englert, J. A., & Choi, A. M. K. (2011) · Autophagy · doi:10.4161/auto.7.6.15100 · Cited by 152 · see citing works

Neurons require glucose uptake and glycolysis in vivo

Li, H., Guglielmetti, C., Sei, Y. J., Zilberter, M. Y., Page, L. M. L., Shields, L. Y., Yang, J. L., Nguyen, K., Tiret, B., Gao, X. Z., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112335 · Cited by 143 · see citing works

A role for autophagy in Huntington's disease

Croce, K. R., & Yamamoto, A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.010 · Cited by 139 · see citing works

Sex and Life Expectancy

Seifarth, J., McGowan, C. L. M., & Milne, K. J. (2012) · Gender Medicine · doi:10.1016/j.genm.2012.10.001 · Cited by 139 · see citing works

Autophagy in Neurotrauma: Good, Bad, or Dysregulated

Wu, J., & Lipinski, M. M. (2019) · Cells · doi:10.3390/cells8070693 · Cited by 125 · see citing works

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

Oh, T. S., Cho, H., Cho, J. H., Yu, S.-W., & Kim, E. K. (2016) · Autophagy · doi:10.1080/15548627.2016.1215382 · Cited by 121 · see citing works

Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells

Addis, R., Campesi, I., Fois, M., Capobianco, G., Dessole, S., Fenu, G., Montella, A., Cattaneo, M. G., Vicentini, L. M., & Franconi, F. (2014) · Biology of Sex Differences · doi:10.1186/s13293-014-0018-2 · Cited by 120 · see citing works

Regulation and Roles of Autophagy at Synapses

Nikoletopoulou, V., & Tavernarakis, N. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.006 · Cited by 115 · see citing works

Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

Fujimoto, K., Hanson, P. T., Tran, H. D., Ford, E. L., Han, Z., Johnson, J. D., Schmidt, R. E., Green, K. G., Wice, B. M., & Polonsky, K. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041616 · Cited by 116 · see citing works

Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity

Ruggieri, A., Barbati, C., & Malorni, W. (2010) · International Journal of Cancer · doi:10.1002/ijc.25298 · Cited by 114 · see citing works

Sexual Dimorphism in Ischemic Stroke: Lessons from the Laboratory

Manwani, B., & McCullough, L. D. (2011) · Women s Health · doi:10.2217/whe.11.22 · Cited by 110 · see citing works

Clinical translational failure in neuroprotective agents: the steps from animal experiments to clinical trials

Xu, S.-Y., & Pan, S.-Y. (2013) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.883750 · Cited by 108 · see citing works

Lipid Droplet Biogenesis Induced by Stress Involves Triacylglycerol Synthesis That Depends on Group VIA Phospholipase A2

Gubern, A., Barceló-Torns, M., Casas, J., Barneda, D., Masgrau, R., Picatoste, F., Balsinde, J., Balboa, M. A., & Claro, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806173200 · Cited by 107 · see citing works

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

Gabryel, B., Kost, A., & Kasprowska, D. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70725-9 · Cited by 107 · see citing works

Sex differences in ischaemic stroke: potential cellular mechanisms

Chauhan, A., Moser, H., & McCullough, L. D. (2017) · Clinical Science · doi:10.1042/cs20160841 · Cited by 105 · see citing works

Emerging Links between Lipid Droplets and Motor Neuron Diseases

Pennetta, G., & Welte, M. A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.002 · Cited by 103 · see citing works

Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing

Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y., & Ren, J. T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101129 · Cited by 103 · see citing works

The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods

Hou, K., Xu, D., Li, F., Chen, S., & Li, Y. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.03.015 · Cited by 98 · see citing works

Sex differences in lipid metabolism and metabolic disease risk

Sugiyama, M. G., & Agellon, L. B. (2012) · Biochemistry and Cell Biology · doi:10.1139/o11-067 · Cited by 96 · see citing works

Autophagy in acute brain injury: Feast, famine, or folly?

Smith, C. M., Chen, Y., Sullivan, M. L. G., Kochanek, P. M., & Clark, R. S. B. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.014 · Cited by 93 · see citing works

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

Smith, E. D., Prieto, G. A., Tong, L., Sears‐Kraxberger, I., Rice, J. D., Steward, O., & Cotman, C. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568659 · Cited by 90 · see citing works

A C9orf72–CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stressPreprint

Liu, Y., Wang, T., Ji, Y. J., Johnson, K., Liu, H., Johnson, K., Bailey, S., Suk, Y., Lu, Y., Liu, M., et al. (2018) · Genes & Development · doi:10.1101/gad.315564.118 · Cited by 83 · see citing works

Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model

Muralimanoharan, S., Gao, X., Weintraub, S. T., Myatt, L., & Maloyan, A. (2016) · Autophagy · doi:10.1080/15548627.2016.1156822 · Cited by 83 · see citing works

Glial β-oxidation regulates Drosophila energy metabolism

Schulz, J. G., Laranjeira, A., Van Huffel, L., Gärtner, A., Vilain, S., Bastianen, J., Van Veldhoven, P. P., & Dotti, C. G. (2015) · Scientific Reports · doi:10.1038/srep07805 · Cited by 82 · see citing works

Review: Autophagy and neurodegeneration: survival at a cost?

Cherra, S. J., Dagda, R., & Chu, C. T. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01062.x · Cited by 99 · see citing works

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Congdon, E. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00372 · Cited by 81 · see citing works

Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells

Bennett, H. L., Fleming, J., O’Prey, J., Ryan, K. M., & Leung, H. Y. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.50 · Cited by 78 · see citing works

Does cellular sex matter? Dimorphic transcriptional differences between female and male endothelial cells

Lorenz, M., Koschate, J., Kaufmann, K., Kreye, C., Mertens, M., Kuebler, W. M., Baumann, G., Gossing, G., Márki, A., Zakrzewicz, A., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.02.018 · Cited by 77 · see citing works

AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance

Benito‐Cuesta, I., Ordóñez‐Gutiérrez, L., & Wandosell, F. G. (2020) · Autophagy · doi:10.1080/15548627.2020.1728095 · Cited by 76 · see citing works

Sex differences in cerebral ischemia: Possible molecular mechanisms

Siegel, C. S., Turtzo, L. C., & McCullough, L. D. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22406 · Cited by 74 · see citing works

Autophagy and Ischemic Stroke

Zhang, Y., Cao, Y., & Liu, C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-4272-5_7 · Cited by 72 · see citing works

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

Wang, M.-D., Wu, H., Huang, S., Zhang, H., Qin, C., Zhao, L., Fu, G., Zhou, X., Wang, X., Tang, L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6817 · Cited by 72 · see citing works

Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: Effects of age and sex

Ahern, T. H., Krug, S., Carr, A. V., Murray, E. K., Fitzpatrick, E. G., Bengston, L., McCutcheon, J., Vries, G. J. D., & Forger, N. G. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23298 · Cited by 70 · see citing works

Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia

Demarest, T. G., Waite, E. L., Kristián, T., Puché, A. C., Waddell, J., McKenna, M. C., & Fiskum, G. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.026 · Cited by 70 · see citing works

Mitochondrial maintenance failure in aging and role of sexual dimorphism

Tower, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.10.008 · Cited by 67 · see citing works

Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases

Hu, Z., Yang, B., Mo, X., & Xiao, H. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8921-4 · Cited by 68 · see citing works

Sex differences in pediatric traumatic brain injury

Arambula, S. E., Reinl, E. L., Demerdash, N. E., McCarthy, M. M., & Robertson, C. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.02.016 · Cited by 65 · see citing works

Inhibition of autophagy as a therapeutic strategy of iron-induced brain injury after hemorrhage

Chen, C.-W., Chen, T.-Y., Tsai, K.-L., Lin, C., Yokoyama, K. K., Lee, W., Chiueh, C. C., & Hsu, C. (2012) · Autophagy · doi:10.4161/auto.21289 · Cited by 65 · see citing works

New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer’s disease

Cao, Y., Zhao, L., Chen, Z., & Li, S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1430465 · Cited by 58 · see citing works

Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen–glucose deprivation) models

Meloni, B. P., Meade, A. J., Kitikomolsuk, D., & Knuckey, N. W. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.11.023 · Cited by 62 · see citing works

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

Ramamurthy, S., & Ronnett, G. V. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.2.52 · Cited by 60 · see citing works

JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase A2

Gubern, A., Barceló-Torns, M., Barneda, D., López, J. M., Masgrau, R., Picatoste, F., Chalfant, C. E., Balsinde, J., Balboa, M. A., & Claro, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061515 · Cited by 60 · see citing works

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

Sadasivan, S., Zhang, Z., Larner, S. F., Liu, M. C., Zheng, W., Kobeissy, F. H., Hayes, R. L., & Wang, K. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-21 · Cited by 56 · see citing works

Sex Differences in Constitutive Autophagy

Oliván, S., Calvo, A. C., Manzano, R., Zaragoza, P., & Osta, R. (2014) · BioMed Research International · doi:10.1155/2014/652817 · Cited by 55 · see citing works

Gangliosides induce autophagic cell death in astrocytes

Hwang, J., Lee, S., Lee, J. T., Kwon, T. K., Kim, D. R., Kim, H., Park, H., & Suk, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00563.x · Cited by 54 · see citing works

Links between autophagy and lipid droplet dynamics

Xu, C., & Fan, J. (2022) · Journal of Experimental Botany · doi:10.1093/jxb/erac003 · Cited by 54 · see citing works

Cell sex determines anoikis resistance in vascular smooth muscle cells

Straface, E., Vona, R., Gambardella, L., Ascione, B., Marino, M., Bulzomi, P., Canu, S., Coinu, R., Rosano, G. M. C., Malorni, W., et al. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.052 · Cited by 52 · see citing works

Lipid Droplets: Their Role in Nanoparticle-Induced Oxidative Stress

Khatchadourian, A., & Maysinger, D. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900098p · Cited by 51 · see citing works

The Potential for Bio-Mediators and Biomarkers in Pediatric Traumatic Brain Injury and Neurocritical Care

Kochanek, P. M., Berger, R. P., Fink, E. L., Au, A. K., Bayır, H., Bell, M. J., Dixon, C. E., & Clark, R. S. B. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00040 · Cited by 51 · see citing works

The Effect of Specialist Neurosciences Care on Outcome in Adult Severe Head Injury

Fuller, G. W., Bouamra, O., Woodford, M., Jenks, T., Patel, H., Coats, T., Oakley, P. A., Mendelow, A. D., Pigott, T., Hutchinson, P. J., et al. (2011) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e3182161816 · Cited by 51 · see citing works

The role of autophagy in acute brain injury: A state of flux?

Wolf, M. S., Bayır, H., Kochanek, P. M., & Clark, R. S. B. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.04.018 · Cited by 51 · see citing works

Preclinical models in the study of sex differences

Buoncervello, M., Marconi, M., Carè, A., Piscopo, P., Malorni, W., & Matarrese, P. (2017) · Clinical Science · doi:10.1042/cs20160847 · Cited by 47 · see citing works

Protein oxidation seems to be linked to constitutive autophagy: A sex study

Campesi, I., Straface, E., Occhioni, S., Montella, A., & Franconi, F. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.06.001 · Cited by 42 · see citing works

Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective

Kalra, P., Khan, H., Kaur, A., & Singh, T. G. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03500-0 · Cited by 41 · see citing works

Gender-related disparities in non-small cell lung cancer

Paggi, M. G., Vona, R., Abbruzzese, C., & Malorni, W. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.08.009 · Cited by 40 · see citing works

The impact of gender on stroke pathology and treatment

Gibson, C. L., & Attwood, L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.020 · Cited by 39 · see citing works

Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients

Li, H., Qiu, S., Li, X., Li, M., & Peng, Y. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0726-3 · Cited by 38 · see citing works

Gender Differences Involved in the Pathophysiology of the Perinatal Hypoxic-Ischemic Damage

MURDEN, S., Borbélyová, V., Laštůvka, Z., Mysliveček, J., Otáhal, J., & RILJAK, V. (2019) · Physiological Research · doi:10.33549/physiolres.934356 · Cited by 37 · see citing works

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

Jiang, P., Gan, M., Lin, W.-L., & Yen, S.-H. C. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00268 · Cited by 37 · see citing works

Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro

Au, A. K., Chen, Y., Du, L., Smith, C. M., Manole, M. D., Baltagi, S. A., Chu, C. T., Aneja, R. K., Bayır, H., Kochanek, P. M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.06.007 · Cited by 35 · see citing works

Sex-dependent differences in the secretome of human endothelial cells

Cattaneo, M. G., Banfi, C., Brioschi, M., Lattuada, D., & Vicentini, L. M. (2021) · Biology of Sex Differences · doi:10.1186/s13293-020-00350-3 · Cited by 35 · see citing works

Sex-Associated Differences in Neurovascular Dysfunction During Ischemic Stroke

Tang, T., Hu, L., Liu, Y., Fu, X., Li, J., Yan, F., Cao, S., & Chen, G. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.860959 · Cited by 33 · see citing works

Transcriptomic dissection of sexual differences in Bemisia tabaci, an invasive agricultural pest worldwide

Xie, W., Guo, L., Jiao, X., Yang, N., Yang, X., Wu, Q., Wang, S., Zhou, X. J., & Zhang, Y. (2014) · Scientific Reports · doi:10.1038/srep04088 · Cited by 33 · see citing works

In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression

Marı́n, C., & Aguilar, E. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.01.010 · Cited by 33 · see citing works

High-fat feeding does not induce an autophagic or apoptotic phenotype in female rat skeletal muscle

Campbell, T. L., Mitchell, A. S., McMillan, E. M., Bloemberg, D., Pavlov, D., Messa, I., Mielke, J. G., & Quadrilatero, J. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214557223 · Cited by 33 · see citing works

T-cell involvement in sex differences in blood pressure control

Crislip, G. R., & Sullivan, J. C. (2016) · Clinical Science · doi:10.1042/cs20150620 · Cited by 32 · see citing works

Sex and Brain: The Role of Sex Chromosomes and Hormones in Brain Development and Parkinson’s Disease

Terrin, F., Tesoriere, A., Plotegher, N., & Valle, L. D. (2023) · Cells · doi:10.3390/cells12111486 · Cited by 31 · see citing works

Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Moruno-Manchon, J., Noh, B., & McCullough, L. D. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.340406 · Cited by 31 · see citing works

The Role of Sex Differences in Autophagy in the Heart During Coxsackievirus B3-Induced Myocarditis

Koenig, A., Sateriale, A., Budd, R. C., Huber, S. A., & Buskiewicz, I. A. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9525-5 · Cited by 31 · see citing works

Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke

Patrizz, A., Moruno-Manchon, J. F., O’Keefe, L. M., Doran, S. J., Patel, A. R., Venna, V. R., Tsvetkov, A. S., Li, J., & McCullough, L. D. (2021) · Cells · doi:10.3390/cells10071825 · Cited by 24 · see citing works

Sex does not influence neuronal autophagosome biogenesis throughout aging in mice

Rodriguez, M. N., & Stavoe, A. K. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-07-0312 · Cited by 2 · see citing works

Abstract 3432: Sex-dependent Differences in Autophagy After Experimentally-induced Stroke

Adami, A. J., O’Keefe, L. M., Venna, V. R., Li, J., Siegel, C. S., Benashski, S. E., & McCullough, L. D. (2012) · Stroke · doi:10.1161/str.43.suppl_1.a3432

Sex does not Influence Neuronal Autophagy throughout Aging in MicePreprint

Rodruiguez, M. N., & Stavoe, A. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.16.633428

Defective autophagy in Sf1 neurons perturbs the metabolic response to fasting and causes mitochondrial dysfunction

Coupé, B., Leloup, C., Asiedu, K., Maillard, J., Pénicaud, L., Horváth, T. L., & Bouret, S. G. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101186 · Cited by 14 · see citing works