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Cited by 345

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Engineering an in vitro air-blood barrier by 3D bioprinting

Open access
Horváth, Lenke, Umehara, Yuki, Jud, Corinne, Blank, Fabian, Petri-Fink, Alke, Rothen-Rutishauser, Barbara·2015·Scientific Reports

Abstract

Intensive efforts in recent years to develop and commercialize in vitro alternatives in the field of risk assessment have yielded new promising two- and three dimensional (3D) cell culture models. Nevertheless, a realistic 3D in vitro alveolar model is not available yet. Here we report on the biofabrication of the human air-blood tissue barrier analogue composed of an endothelial cell, basement membrane and epithelial cell layer by using a bioprinting technology. In contrary to the manual method, we demonstrate that this technique enables automatized and reproducible creation of thinner and more homogeneous cell layers, which is required for an optimal air-blood tissue barrier. This bioprinting platform will offer an excellent tool to engineer an advanced 3D lung model for high-throughput screening for safety assessment and drug efficacy testing.

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Metadata

Authors
Horváth, L., Umehara, Y., Jud, C., Blank, F., Petri-Fink, A., & Rothen-Rutishauser, B.
Venue
Scientific Reports
Published
2015-01-22
Volume
5
Issue
1
Pages
7974-7974
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2084261722
Cited by
345
References
6
FWCI
16.20
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Engineering an in vitro air-blood barrier by 3D bioprinting. https://app.cochat.ai/papers/10.1038/srep07974
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Horváth, L., Umehara, Y., Jud, C., Blank, F., Petri-Fink, A., & Rothen-Rutishauser, B. (2015). Engineering an in vitro air-blood barrier by 3D bioprinting. Scientific Reports. https://doi.org/10.1038/srep07974

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