Near-infrared (NIR) up-conversion optogenetics
Open accessAbstract
Non-invasive remote control technologies designed to manipulate neural functions have been long-awaited for the comprehensive and quantitative understanding of neuronal network in the brain as well as for the therapy of neurological disorders. Recently, it has become possible for the neuronal activity to be optically manipulated using biological photo-reactive molecules such as channelrhodopsin (ChR)-2. However, ChR2 and its relatives are mostly reactive to visible light, which does not effectively penetrate through biological tissues. In contrast, near-infrared (NIR) light (650-1450 nm) penetrates deep into the tissues because biological systems are almost transparent to light within this so-called 'imaging window'. Here we used lanthanide nanoparticles (LNPs), composed of rare-earth elements, as luminous bodies to activate ChRs since they absorb low-energy NIR light to emit high-energy visible light (up-conversion). Here, we created a new type of optogenetic system which consists of the donor LNPs and the acceptor ChRs. The NIR laser irradiation emitted visible light from LNPs, then induced the photo-reactive responses in the near-by cells that expressed ChRs. However, there remains room for large improvements in the energy efficiency of the LNP-ChR system.
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NIR light appears to mitigate some issues of effective transmission distance such as tissue opacity, scattering, and absorption.
“However, NIR light appears to mitigate some of these issues (Hososhima et al., 2015).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Hososhima et al., 2015
The wavelength of light for optical charging is usually selected to be in the near-infrared (NIR) range because of its deeper penetration into biological tissues.
“The wavelength of light is usually selected to be in the near-infrared (NIR) range, owing to its deeper penetration into biological tissues (Hososhima et al., 2015).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Hososhima et al., 2015
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- Authors
- Hososhima, S., Yuasa, H., Ishizuka, T., Hoque, M. R., Yamashita, T., Yamanaka, A., Sugano, E., Tomita, H., & Yawo, H.
- Affiliations
- Tohoku University (JP)
- Tokyo Institute of Technology (JP)
- Research Institute of Environmental Medicine, Nagoya University (JP)
- Iwate University (JP)
- Corresponding author
- Yawo, Hiromu
- ORCID
- Venue
- Scientific Reports
- Published
- 2015-11-10
- Volume
- 5
- Issue
- 1
- Pages
- 16533-16533
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4639720
- OpenAlex
- W2100847211
- Cited by
- 126
- References
- 38
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 17 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 1
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Iwate University Repository (Iwate University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (25250001, 15K15025, 15H01413, 25670103, CREST, 25290002, 25115701)
- National Institute of Biomedical Innovation
- Japan Society for the Promotion of Science (25462747, 25115701, 15H01413, 25250001, 15K14313, 25670103, CREST, 13J06372, 15K15025, 25290002, 26670750)
- Japan Science and Technology Agency (CREST)
- Core Research for Evolutional Science and Technology
- Collaborative Research Based on Industrial Demand
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- optogenetics, near-infrared light, lanthanide nanoparticles, upconversion, channelrhodopsin-2, deep tissue penetration, energy efficiency
- MeSH terms
- Animals, Infrared Rays, Neurons, Spectroscopy, Near-Infrared, Lanthanoid Series Elements, Mice, Rats, Metal Nanoparticles, Optogenetics
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