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Cited by 41

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Associations between serum 25-hydroxyvitamin D and bone turnover markers in a population based sample of German children

Thiering, E., Brüske, I., Kratzsch, J., Hofbauer, L. C., Berdel, D., von Berg, A., Lehmann, I., Hoffmann, B., Bauer, C. P., Koletzko, S., Heinrich, J.·2015·Scientific Reports
DOI 10.1038/srep18138
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Abstract

Severe vitamin D deficiency is known to cause rickets, however epidemiological studies and RCTs did not reveal conclusive associations for other parameters of bone health. In our study, we aimed to investigate the association between serum levels of 25(OH) vitamin D and bone turnover markers in a population-based sample of children. 25(OH)D, calcium (Ca), osteocalcin (OC) and β-Crosslaps (β-CTx) were measured in 2798 ten-year-old children from the German birth cohorts GINIplus and LISAplus. Linear regression was used to determine the association between bone turnover markers and 25(OH)D levels. 25(OH)D, OC and β-CTx showed a clear seasonal variation. A 10 nmol/l increase in 25(OH)D was significantly associated with a 10.5 ng/l decrease (p < 0.001) in β-CTx after adjustment for design, sex, fasting status, time of blood drawn, BMI, growth rate and detectable testosterone/estradiol. For OC alone no significant association with 25(OH)D was observed, whereas the β-CTx-to-OC ratio was inversely associated with 25(OH)D (−1.7% change, p < 0.001). When stratifying the analyses by serum calcium levels, associations were stronger in children with Ca levels below the median. This study in school-aged children showed a seasonal variation of 25(OH)D and the bone turnover markers OC and β-CTx. Furthermore a negative association between 25(OH)D and the bone resorption marker β-CTx was observed.

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Research works printed but not linked: 29

  1. Jones, G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88, 582S–586S (2008). · DOI · Paper page
  2. Atkins, G. J. et al. Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3. Bone 40, 1517–28 (2007). · DOI · Paper page
  3. van Driel, M. & van Leeuwen. J. P. Vitamin D endocrine system and osteoblasts. Bonekey Rep 3, 493 (2014). · DOI
  4. Winzenberg, T., Powell, S., Shaw, K. A. & Jones, G. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ 342, c7254 (2011). · DOI
  5. Reid, I. R., Bolland, M. J. & Grey, A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 383, 146–55 (2014). · DOI · Paper page
  6. Berg, A. et al. Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course - the GINIplus study up to the age of 6 years. Clin Exp Allergy 40, 627–36 (2010). · DOI
  7. Zutavern, A. et al. Timing of solid food introduction in relation to atopic dermatitis and atopic sensitization: results from a prospective birth cohort study. Pediatrics 117, 401–11 (2006). · DOI · Paper page
  8. Knudsen, C. S., Nexo, E., Højskov, C. S. & Heickendorff, L. Analytical validation of the Roche 25-OH Vitamin D Total assay. Clin Chem Lab Med 50(11), 1965–8 (2012). · DOI
  9. Emmen, J. M., Wielders, J. P., Boer, A. K., van den Ouweland, J. M. & Vader, H. L. The new Roche Vitamin D Total assay: fit for its purpose? Clin Chem Lab Med 8, 0(0):1–4 (2012). · DOI
  10. Janssen, I. Physical activity guidelines for children and youth. Can J Public Health 98 Suppl 2, S109–21 (2007).
  11. Gracia-Marco, L. et al. Bone mass and bone metabolism markers during adolescence: The HELENA Study. Horm Res Paediatr 74, 339–50 (2010). · DOI
  12. Kanbur, N. O., Derman, O., Sen, T. A. & Kinik, E. Osteocalcin. A biochemical marker of bone turnover during puberty. Int J Adolesc Med Health 14(3), 235 44. · DOI
  13. Matsukura, T. et al. The characteristics of bone turnover in the second decade in relation to age and puberty development in healthy Japanese male and female subjects–Japanese Population-based Osteoporosis Study. Ann Hum Biol 30(1), 13–25. · DOI
  14. Kuchuk, N. O. et al. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons J Clin Endocrinol Metab 94, 1244–50 (2009). · DOI · Paper page
  15. Ardawi, M. S., Qari, M. H., Rouzi, A. A., Maimani, A. A. & Raddadi, R. M. Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. Osteoporos Int 22, 463–75 (2011). · DOI
  16. Jones, G., Dwyer, T., Hynes, K. L., Parameswaran, V. & Greenaway, T. M. Vitamin D insufficiency in adolescent males in Southern Tasmania: prevalence, determinants and relationship to bone turnover markers. Osteoporos Int 16, 636–41 (2005). · DOI
  17. Viljakainen, H. T. et al. A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study. Br J Nutr 96, 124–30 (2006). · DOI
  18. Fares, J. E. et al. Effect of gender, puberty and vitamin D status on biochemical markers of bone remodedeling. Bone 33, 242–7 (2003). · DOI
  19. Rajakumar, K. et al. Impact of seasonal flux on 25-hydroxyvitamin D and bone turnover in pre- and early pubertal youth. Pediatr Int 56, 35–42 (2014). · DOI
  20. Ginty, F. et al. Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents. Eur J Clin Nutr 58, 1257–65 (2004). · DOI
  21. Foo, L. H. et al. Low vitamin D status has an adverse influence on bone mass, bone turnover and muscle strength in Chinese adolescent girls. J Nutr 139, 1002–7 (2009). · DOI
  22. Ilich, J. Z. et al. Calcitriol and bone mass accumulation in females during puberty. Calcif Tissue Int 61, 104–9 (1997). · DOI
  23. Cashman, K. D. et al. Low vitamin D status adversely affects bone health parameters in adolescents. Am J Clin Nutr 87, 1039–44 (2008). · DOI · Paper page
  24. Hill, T. R. et al. Vitamin D status and parathyroid hormone relationship in adolescents and its association with bone health parameters: analysis of the Northern Ireland Young Heart’s Project. Osteoporos Int 21, 695–700 (2010). · DOI
  25. Hill, K. M. et al. Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children. Bone 51, 795–9 (2012). · DOI
  26. Mølgaard, C. et al. Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization? Bone 46, 432–9 (2010). · DOI
  27. Enko, D. et al. 25-hydroxy-Vitamin D status: limitations in comparison and clinical interpretation of serum-levels across different assay methods. Clin Lab 60(9), 1541–50 (2014). · DOI
  28. Lämmle, L., Bergmann, K., Bös, K. & Koletzko, B. Predictors of differences in vitamin D levels in children and adolescents and their relation to endurance performance. Ann Nutr Metab 62(1), 55–62 (2013). · DOI
  29. Looker, A. C. et al. Vitamin D status: United States, 2001-2006. NCHS Data Brief 2011(59), 1–8.

Cited by

Metadata

Authors
Thiering, E., Brüske, I., Kratzsch, J., Hofbauer, L. C., Berdel, D., von Berg, A., Lehmann, I., Hoffmann, B., Bauer, C. P., Koletzko, S., & Heinrich, J.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2015-12-15
Volume
5
Issue
1
ISSN
2045-2322
DOI
10.1038/srep18138
Cited by
41
References
1
Language
en
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