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Exosome mediated biological functions within skeletal microenvironment

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Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

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Immunomodulatory and Regenerative Functions of MSC-Derived Exosomes in Bone Repair

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Bone marrow mesenchymal stem cell’s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type

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Different exosomes are loaded in hydrogels for the application in the field of tissue repair

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Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration

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Adipose stem cells-derived exosomes modified gelatin sponge promotes bone regeneration

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Extracellular vesicles as a novel therapeutic tool for cell‐free regenerative medicine in oral rehabilitation

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Biomaterials and extracellular vesicles in cell-free therapy for bone repair and regeneration: Future line of treatment in regenerative medicine

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MicroRNAs-containing extracellular vesicles in bone remodeling: An emerging frontier

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Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disorders

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Comparison Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation

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The Potential Roles of Exosomal miR-214 in Bone Metastasis of Lung Adenocarcinoma

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Exploring a Chemotactic Role for EVs from Progenitor Cell Populations of Human Exfoliated Deciduous Teeth for Promoting Migration of Naïve BMSCs in Bone Repair Process

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Micro‐Nanostructures of Cellulose‐Collagen for Critical Sized Bone Defect Healing

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Bone aging and extracellular vesicles

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Overexpressed miR‐196a accelerates osteogenic differentiation in osteoporotic mice via GNAS‐dependent Hedgehog signaling pathway

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Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future

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Potential Effects of Exosomes and their MicroRNA Carrier on Osteoporosis

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Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Use in Central Nervous System Demyelinating Disorders

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Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells

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Exosomes: A Friend or Foe for Osteoporotic Fracture?

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PLGA Containing Human Adipose‐Derived Stem Cell‐Derived Extracellular Vesicles Accelerates the Repair of Alveolar Bone Defects via Transfer of CGRP

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Human umbilical cord mesenchymal stem cells derived extracellular vesicles alleviate salpingitis by promoting M1–to–M2 transformation

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Extracellular vesicles: Emerged as a promising strategy for regenerative medicine

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Role of nano-hydrogels coated exosomes in bone tissue repair

Pan, Y., Li, Y., Dong, W., Jiang, B., Yu, Y., & Chen, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1167012 · Cited by 24

Effect of psoralen on the regulation of osteogenic differentiation induced by periodontal stem cell-derived exosomes

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Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells

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Mesenchymal stromal cell-derived extracellular vesicles for bone regeneration therapy

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Biomaterials constructed for MSC-derived extracellular vesicle loading and delivery—a promising method for tissue regeneration

Yu, L., Yu, Y., Liu, S., & Ge, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.898394 · Cited by 23

Exosomes Enhance Adhesion and Osteogenic Differentiation of Initial Bone Marrow Stem Cells on Titanium Surfaces

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Simple application of adipose-derived stem cell-derived extracellular vesicles coating enhances cytocompatibility and osteoinductivity of titanium implant

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Extracellular Vesicles: Potential Mediators of Psychosocial Stress Contribution to Osteoporosis?

He, Y., Wuertz‐Kozak, K., Kuehl, L. K., & Wippert, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115846 · Cited by 20

An injectable hydroxypropyl-β-cyclodextrin cross-linked gelatin-based hydrogel loaded bone mesenchymal stem cell for osteogenic and in vivo bone regeneration of femoral head necrosis

Yuan, S. S., Han, Y., Xiang, D., Wang, B., Chen, Y., & Hao, Y. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102521 · Cited by 22

How Do Extracellular Vesicles Play a Key Role in the Maintenance of Bone Homeostasis and Regeneration? A Comprehensive Review of Literature

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Using Pre-Clinical Studies to Explore the Potential Clinical Uses of Exosomes Secreted from Induced Pluripotent Stem Cell-Derived Mesenchymal Stem cells

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Advances in the Study of Extracellular Vesicles for Bone Regeneration

Yao, J., Liu, Y., Du, J., Xu, J., Luo, Z., Liu, Y. F., & Guo, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063480 · Cited by 24

Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration

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Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Samal, S., Dash, P., & Dash, M. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s307843 · Cited by 22

Exosomes in bone remodeling and breast cancer bone metastasis

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Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

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Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

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Fracture Healing and the Underexposed Role of Extracellular Vesicle-Based Cross Talk

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Dexamethasone-Activated MSCs Release MVs for Stimulating Osteogenic Response

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MSC-Derived Extracellular Vesicles: New Emergency Treatment to Limit the Development of Radiation-Induced Hematopoietic Syndrome?

Cavallero, S., Riccobono, D., Drouet, M., & François, S. (2020) · Health Physics · doi:10.1097/hp.0000000000001264 · Cited by 21

Mechanism of Exosomes Involved in Osteoimmunity Promoting Osseointegration Around Titanium Implants With Small-Scale Topography

Zhang, T., Jiang, M., Yin, X., Yao, P., & Sun, H. Q. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.682384 · Cited by 21

Extracellular Vesicles and Acute Kidney Injury: Potential Therapeutic Avenue for Renal Repair and Regeneration

Kosanović, M., Milutinovic, B. S., Glamočlija, S., Morlans, I. M., Ortíz, A., & Božić, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073792 · Cited by 23

Extracellular Vesicle-Integrated Biomaterials in Bone Tissue Engineering Applications: Current Progress and Future Perspectives

Huang, Y. L., & Xie, H. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s522198 · Cited by 20

Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients

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Therapeutic application of extracellular vesicles for musculoskeletal repair & regeneration

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Osteoporosis treatment by mesenchymal stromal/stem cells and their exosomes: Emphasis on signaling pathways and mechanisms

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Well-orchestrated physico-chemical and biological factors for enhanced secretion of osteogenic and angiogenic extracellular vesicles by mesenchymal stem cells in a 3D culture format

Holkar, K., Kale, V. P., & Ingavle, G. C. (2022) · Biomaterials Science · doi:10.1039/d2bm00750a · Cited by 19

Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation

Skelton, A. M., Cohen, D. J., Boyan, B. D., & Schwartz, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612770 · Cited by 19

Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis

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Nature-derived epigallocatechin gallate/duck’s feet collagen/hydroxyapatite composite sponges for enhanced bone tissue regeneration

Kook, Y. J., Tian, J., Jeon, Y. S., Choi, M. J., Song, J. E., Park, C. H., Reis, R. L., & Khang, G. (2017) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2017.1414480 · Cited by 19

Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis

Giannandrea, D., Citro, V., Lesma, E. A., Bignotto, M., Platonova, N., & Chiaramonte, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.644109 · Cited by 20

Extracellular Vesicle-Based Coatings Enhance Bioactivity of Titanium Implants—SurfEV

Pansani, T. N., Phan, T. H., Lei, Q., Kondyurin, A. V., Kalionis, B., & Chrzanowski, W. (2021) · Nanomaterials · doi:10.3390/nano11061445 · Cited by 19

Stem cell education for medical students at Tongji University: Primary cell culture and directional differentiation of rat bone marrow mesenchymal stem cells

Jin, C., Tian, H., Li, J., Jia, S., Li, S., Xu, G., Xu, L., & Lü, L. (2017) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.21098 · Cited by 19

Extracellular vesicles secreted from mouse muscle cells improve delayed bone repair in diabetic mice

Takafuji, Y., Kawao, N., Ohira, T., Mizukami, Y., Okada, K., Jo, J., Tabata, Y., & Kaji, H. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej22-0340 · Cited by 18

Stem Cell-Derived Extracellular Vesicles for Cancer Therapy and Tissue Engineering Applications

Lee, C., Lee, M., Na, K., & Hwang, H. S. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00376 · Cited by 18

Bone Regeneration Revolution: Pulsed Electromagnetic Field Modulates Macrophage-Derived Exosomes to Attenuate Osteoclastogenesis

Trentini, M., D’Amora, U., Ronca, A., Lovatti, L., Calvo‐Guirado, J. L., Licastro, D., Monego, S. D., Delogu, L. G., Wieckowski, M. R., Barak, S., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s470901 · Cited by 19

Enrichment of miR-126 enhances the effects of endothelial progenitor cell–derived microvesicles on modulating MC3T3-E1 cell function via Erk1/2-Bcl-2 signalling pathway

Chen, G., Li, P., Liu, Z., Zeng, R., Ma, X., Chen, Y., Xu, H., Li, Z., & Lin, H. (2019) · Prion · doi:10.1080/19336896.2019.1607464 · Cited by 18

Extracellular vesicles derived from starving BMSCs enhance survival of chondrocyte aggregates in grafts by attenuating chondrocyte apoptosis and enabling stable cartilage regeneration for craniofacial reconstruction

Yuan, P., Li, Z., Shao, B., Zeng, T., Wu, X., Wang, Y., Zhao, Y., & Wu, W. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.12.011 · Cited by 19

Modern Approaches to Acellular Therapy in Bone and Dental Regeneration

Aa, I., Kuznetsova, A. V., Попова, О. П., Danilova, T. I., & Yanushevich, O. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413454 · Cited by 21

Therapeutic strategy for exosome-based bone regeneration to osteoporosis: Challenges and potential solutions

Dayanandan, A. P., Bello, A. B., Arai, Y., Lee, S. J., & Lee, S.-H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.042 · Cited by 18

Kinship of conditionally immortalized cells derived from fetal bone to human bone-derived mesenchymal stroma cells

Marozin, S., Simon‐Nobbe, B., Irausek, S., Chung, L. W. K., & Lepperdinger, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-90161-2 · Cited by 17

Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier

Spiers, H. V. M., Stadler, L. K. J., Smith, H., & Kosmoliaptsis, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030891 · Cited by 18

The safety and efficacy of mesenchymal stem cell therapy in diabetic lower extremity vascular disease: a meta-analysis and systematic review

Jin, L., Wang, X., Qiao, Z., & Deng, Y. (2021) · Cytotherapy · doi:10.1016/j.jcyt.2021.08.001 · Cited by 16

Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p/Aplnr axis

Sheng, C., Guo, X., Wan, Z., Bai, X., Liu, H., Zhang, X., Zhang, P., Liu, Y., Li, W., Zhou, Y., et al. (2022) · Nano Research · doi:10.1007/s12274-022-4554-5 · Cited by 16

Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis

Dong, X., Liu, H., Yuan, D., Gulati, K., & Liu, Y. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02628d · Cited by 17

Uncovering the Diversification of Tissue Engineering on the Emergent Areas of Stem Cells, Nanotechnology and Biomaterials

Dubey, S. K., Alexander, A., Munnangi, S. R., Agrawal, M., Singhvi, G., Sharma, S. K., & Dayaramani, R. A. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200103124821 · Cited by 16

Role of miRNAs in conveying message of stem cells via extracellular vesicles

Ghafouri‐Fard, S., Niazi, V., & Taheri, M. N. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104569 · Cited by 16

Extracellular Vesicles: An Emerging Regenerative Treatment for Oral Disease

He, F., Li, L., Fan, R., Wang, X., Chen, X., & Xu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.669011 · Cited by 17

Role of Exosomal Non-Coding RNAs in Bone-Related Diseases

Li, H., Zheng, Q., Xie, X., Wang, J., Zhu, H., Hu, H., He, H., & Lu, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.811666 · Cited by 16

Small Extracellular Vesicles Derived from Human Chorionic MSCs as Modern Perspective towards Cell-Free Therapy

Janočková, J., Matejová, J., Morávek, M., Homolova, L., Slovinská, L., Nagyova, A., Rak, D., Sedlák, M., Harvanová, D., Špaková, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413581 · Cited by 16

Metallic Scaffold with Micron-Scale Geometrical Cues Promotes Osteogenesis and Angiogenesis via the ROCK/Myosin/YAP Pathway

Liu, Y., Yang, Q., Wang, Y., Lin, M., Tong, Y., Huang, H.-W., Yang, C., Wu, J., Tang, B. H., Bai, J., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00225 · Cited by 17

The miR-4739/DLX3 Axis Modulates Bone Marrow-Derived Mesenchymal Stem Cell (BMSC) Osteogenesis Affecting Osteoporosis Progression

Ding, L., Yuan, Q. X., Xiong, L., Li, A., & Xia, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.703167 · Cited by 15

A smart magnetic hydrogel containing exosome promotes osteogenic commitment of human adipose-derived mesenchymal stem cells.

Sadeghian‐Nodoushan, F., Nikukar, H., Soleimani, M., Jahromi, A. J., Hosseinzadeh, S., & Khojasteh, A. (2022) · PubMed Central · doi:10.22038/ijbms.2022.64682.14237 · Cited by 15

Extracellular vesicles in vaccine development and therapeutic approaches for viral diseases

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