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Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo
Open accessAbstract
Emerging evidence suggests that extracellular vesicles (EVs) are secreted by diverse tissues and play important roles in cell-cell communication, organ interactions and tissue homeostasis. Studies have reported the use of EVs to stimulate tissue regeneration, such as hepatic cell regeneration, and to treat diseases, such as pulmonary hypertension. However, little is known about the osteogenic effect of EVs. In this study, we explore the role of bone marrow stromal cell-derived EVs in the regulation of osteoblast activity and bone regeneration. We isolated bone marrow stromal/stem cell (BMSC)-derived EVs through gradient ultracentrifugation and ultrafiltration, and tested the influence of the EVs on osteogenesis both in vivo and in vitro . The results indicated that EVs positively regulated osteogenic genes and osteoblastic differentiation but did not inhibit proliferation in vitro . Furthermore, we constructed an EVs delivery system to stimulate bone formation in Sprague Dawley (SD) rats with calvarial defects. We found that BMSC-derived EVs led to more bone formation in the critical-size calvarial bone defects. Moreover, we found that miR-196a plays an essential role in the regulation of osteoblastic differentiation and the expression of osteogenic genes. We anticipate that our assay using bone marrow stromal cell-derived EVs will become a valuable tool for promoting bone regeneration.
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“Additional research emphasizes the prominence of pro-osteogenic miRNAs, such as miR-196a, miR-27a, and miR-206, within BM-MSCs EVs [49,51,52].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [51]
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Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Extracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042
Optimized exosome isolation protocol for cell culture supernatant and human plasma
Lobb, R. J., Becker, M., Wen, S., Wong, C. S. F., Wiegmans, A. P., Leimgruber, A., & Möller, A. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27031 · Cited by 1,763
Functional delivery of viral miRNAs via exosomes
Pegtel, D. M., Cosmopoulos, K., Thorley‐Lawson, D. A., van Eijndhoven, M. A. J., Hopmans, E. S., Lindenberg, J. L., de Gruijl, T. D., Würdinger, T., & Middeldorp, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914843107 · Cited by 1,672
Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075
Molecular Characterization of Dendritic Cell-Derived Exosomes
Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065
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Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640
Toh, W. S., Lai, R. C., Hui, J. H. P., & Lim, S. K. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.11.008 · Cited by 511
Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
Ju, Y., Hu, Y., Pu, Y., Xie, X., & Fang, B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100522 · Cited by 471
Bone Tissue Engineering in the Treatment of Bone Defects
Xue, N., Ding, X., Huang, R., Jiang, R., Huang, H., Pan, X., Min, W., Chen, J., Duan, J., Liu, P., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15070879 · Cited by 475
Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., Zhang, X., Wu, G., & Zhou, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17620 · Cited by 463
Bone physiology as inspiration for tissue regenerative therapies
Lopes, D., Martins‐Cruz, C., Oliveira, M. B., & Mano, J. F. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.028 · Cited by 458
Brennan, M. Á., Layrolle, P., & Mooney, D. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909125 · Cited by 399
Zhang, L., Jiao, G., Ren, S., Zhang, X., Li, C., Wu, W., Wang, H., Liu, H., Zhou, H., & Chen, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-1562-9 · Cited by 365
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Gimona, M., Pachler, K., Laner‐Plamberger, S., Schallmoser, K., & Rohde, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061190 · Cited by 330
Tsiapalis, D., & O’Driscoll, L. (2020) · Cells · doi:10.3390/cells9040991 · Cited by 317
Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
Eleuteri, S., & Fierabracci, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184597 · Cited by 311
Dabrowska, S., Andrzejewska, A., Janowski, M., & Łukomska, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591065 · Cited by 302
Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics
Ponzetti, M., & Rucci, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136651 · Cited by 310
Bjørge, I. M., Kim, S. Y., Mano, J. F., Kalionis, B., & Chrzanowski, W. (2017) · Biomaterials Science · doi:10.1039/c7bm00479f · Cited by 277
Zhang, Y., Hao, Z., Wang, P., Xia, Y. Q., Wu, J., Xia, D., Fang, S., & Xu, S. (2019) · Cell Proliferation · doi:10.1111/cpr.12570 · Cited by 280
Long-term and sequential treatment for osteoporosis
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Diomede, F., Gugliandolo, A., Cardelli, P., Merciaro, I., Ettorre, V., Traini, T., Bedini, R., Scionti, D., Bramanti, A., Nanci, A., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0850-0 · Cited by 273
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Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering
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Ciferri, M. C., Quarto, R., & Tasso, R. (2021) · Biology · doi:10.3390/biology10050359 · Cited by 234
To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles
Kusuma, G. D., Barabadi, M., Tan, J. L., Morton, D. A. V., Frith, J. E., & Lim, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01199 · Cited by 226
Takeuchi, R., Katagiri, W., Endo, S., & Kobayashi, T. (2019) · PLOS ONE · doi:10.1371/journal.pone.0225472 · Cited by 210
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
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Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
González-González, A., García‐Sánchez, D., Dotta, M., Rodríguez-Rey, J. C., & Pérez-Campo, F. M. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1529 · Cited by 211
Liu, A., Lin, D., Zhao, H., Chen, L., Cai, B., Lin, K., & Shen, S. G. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120718 · Cited by 201
Lee, K. S., Lee, J., Kim, H. K., Yeom, S. H., Woo, C. H., Jung, Y. J., Yun, Y. E., Park, S. Y., Han, J., Kim, E., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12152 · Cited by 202
Functionally engineered extracellular vesicles improve bone regeneration
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Qin, Y., Sun, R., Wu, C., Wang, L. Y., & Zhang, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050712 · Cited by 187
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Liu, L., Guo, S., Shi, W., Liu, Q., Huo, F., Wu, Y., & Tian, W. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0141 · Cited by 176
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Grangier, A., Branchu, J., Volatron, J., Piffoux, M., Gazeau, F., Wilhelm, C., & Silva, A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113843 · Cited by 183
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Kushioka, J., Chow, S. K., Toya, M., Tsubosaka, M., Shen, H., Gao, Q., Li, X., Zhang, N., & Goodman, S. B. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00279-1 · Cited by 176
Hu, Y., Zhang, Y., Ni, C.-Y., Chen, C., Rao, S., Yin, H., Huang, J., Tan, Y., Wang, Z., Cao, J., et al. (2020) · Theranostics · doi:10.7150/thno.39238 · Cited by 170
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New therapeutic approaches of mesenchymal stem cells-derived exosomes
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Cai, J., Wu, J., Wang, J., Li, Y., Hu, X.-B., Luo, S., & Xiang, D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00427-x · Cited by 144
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Self-citationStem cell‐derived exosomes: A promising strategy for fracture healing
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Pizzicannella, J., Diomede, F., Gugliandolo, A., Chiricosta, L., Bramanti, P., Merciaro, I., Orsini, T., Mazzon, E., & Trubiani, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133256 · Cited by 105
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Exosomes: Mediators of bone diseases, protection, and therapeutics potential
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Gualerzi, A., Kooijmans, S. A. A., Niada, S., Picciolini, S., Brini, A. T., Camussi, G., & Bedoni, M. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1568780 · Cited by 99
Diomede, F., D’Aurora, M., Gugliandolo, A., Merciaro, I., Ettorre, V., Bramanti, A., Piattelli, A., Gatta, V., Mazzon, E., Fontana, A., et al. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s162836 · Cited by 98
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Munoz-Perez, E., Gonzalez‐Pujana, A., Igartúa, M., Santos‐Vizcaíno, E., & Hernández, R. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111802 · Cited by 78
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Zhu, Z., Zhang, Y., Zhang, Y., Zhang, H., Liu, W., Zhang, N., Zhang, X., Zhou, G., Wu, L., Hua, K., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey344 · Cited by 79
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Regenerative Potential and Challenges
Fuloria, S., Subramaniyan, V., Dahiya, R., Dahiya, S., Sudhakar, K., Kumari, U., Sathasivam, K. V., Meenakshi, D. U., Wu, Y. S., Sekar, M., et al. (2021) · Biology · doi:10.3390/biology10030172 · Cited by 78
Liu, T., Hu, W., Zou, X., Xu, J., He, S., Chang, L., Li, X., Yin, Y., Tian, M., Li, Z., et al. (2020) · Stem Cells International · doi:10.1155/2020/8852307 · Cited by 75
Wang, L. Y., Shang, Z., Zhou, Y., Hu, X., Chen, Y., Fan, Y., Wei, X., Wu, L. L., Liang, Q., Zhang, J., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0242-x · Cited by 75
Self-citationHu, Y., Xu, R., Chen, C., Rao, S., Xia, K., Huang, J., Yin, H., Wang, Z., Cao, J., Liu, Z., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.009 · Cited by 77
Wang, N., Liu, X., Tang, Z., Wei, X., Dong, H., Liu, Y., Wu, H., Wu, Z., Li, X., Ma, X., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01267-2 · Cited by 74
Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration
Torrecillas-Baena, B., Pulido-Escribano, V., Dorado, G., Gálvez-Moreno, M. Á., Camacho-Cardeñosa, M., & Casado‐Díaz, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134385 · Cited by 75
Man, K., Brunet, M. Y., Fernández‐Rhodes, M., Williams, S., Heaney, L. M., Gethings, L. A., Federici, A., Davies, O. G., Hoey, D. A., & Cox, S. C. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12118 · Cited by 74
Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair
Wang, D., Cao, H., Hua, W., Gao, L., Yuan, Y. J., Zhou, X., & Zeng, Z. (2022) · Membranes · doi:10.3390/membranes12070716 · Cited by 74
Li, X., Si, Y., Liang, J., Li, M., Wang, Z., Qin, Y., & Sun, L. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.05.209 · Cited by 72
Self-citationStem cell secretome, regeneration, and clinical translation: a narrative review
Gwam, C., Mohammed, N., & Ma, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5030 · Cited by 72
The role and therapeutic potential of MSC-derived exosomes in osteoarthritis
Bao, C., & He, C. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109002 · Cited by 73
Exosomes: A Novel Therapeutic Agent for Cartilage and Bone Tissue Regeneration
Liu, Y., Ma, Y., Zhang, J., Yuan, Y., & Wang, J. (2019) · Dose-Response · doi:10.1177/1559325819892702 · Cited by 70
Zhang, H., Li, X., Li, J., Zhong, L., Chen, X., & Chen, S. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01122-0 · Cited by 69
Metadata
- Authors
- Qin, Y., Wang, L., Gao, Z., Chen, G., & Zhang, C.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Guangdong Medical College (CN)
- Corresponding author
- Chen, Genyin
- Zhang, Changqing
- Venue
- Scientific Reports
- Published
- 2016-02-25
- Volume
- 6
- Issue
- 1
- Pages
- 21961-21961
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4766421
- OpenAlex
- W2417871706
- Cited by
- 458
- References
- 29
- Citations by year
- 2026: 19 · 2025: 40 · 2024: 45 · 2023: 53 · 2022: 61 · 2021: 84 · 2020: 59 · 2019: 41 · 2018: 28 · 2017: 23 · 2016: 5
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- extracellular vesicles, mesenchymal stem cells, osteogenic differentiation, bone formation, bone regeneration, miR-196a, calvarial defect, critical-size bone defect, osteogenic gene expression
- MeSH terms
- Extracellular Vesicles, Animals, Bone and Bones, Bone Marrow Cells, Bone Regeneration, Cell Differentiation, Cells, Cultured, Endoplasmic Reticulum, Flow Cytometry, Golgi Apparatus, Humans, Male, Microscopy, Electron, Osteoblasts, Osteogenesis, Osteocalcin, Rats, Sprague-Dawley, Microscopy, Confocal, MicroRNAs, Rats, Osteopontin, X-Ray Microtomography, Mesenchymal Stem Cells, Real-Time Polymerase Chain Reaction
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