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ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer
Open accessAbstract
The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO 2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO 2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO 2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO 2 NPs as sensitizers for sonodynamic therapy in vivo.
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Cited by
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Multifunctional sonosensitizers in sonodynamic cancer therapy
Son, S., Kim, J. H., Wang, X., Zhang, C., Yoon, S. A., Shin, J., Sharma, A., Lee, M. H., Cheng, L., Wu, J., et al. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00648f · Cited by 1,150
Self-citationYang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Ultrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Carbon Nanotubes: Smart Drug/Gene Delivery Carriers
Zare, H., Ahmadi, S., Ghasemi, A., Ghanbari, M., Rabiee, N., Bagherzadeh, M., Karimi, M., Webster, T. J., Hamblin, M. R., & Mostafavi, E. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s299448 · Cited by 452
Metadata
- Authors
- You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., Pomper, M. G., Kwon, I. C., Kim, K., & Park, J. H.
- Venue
- Scientific Reports
- Published
- 2016-03-21
- Volume
- 6
- Issue
- 1
- Pages
- 23200-23200
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2298818955
- Cited by
- 327
- References
- 0
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., Pomper, M. G., Kwon, I. C., Kim, K., & Park, J. H. (2016). ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer. Scientific Reports. https://doi.org/10.1038/srep23200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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