Multifunctional sonosensitizers in sonodynamic cancer therapy
Abstract
Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer.
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Inherent limitations of current sonosensitizers for breast cancer include low ROS production efficiency and poor tumor targeting.
“This may be owing to the inherent limitations of current sonosensitizers for breast cancer, such as low ROS production efficiency and poor tumor targeting [21].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [21]
Released energy can cause pyrolysis of nearby water to produce hydroxyl radicals.
“In addition, the released energy can also cause a pyrolysis reaction of the nearby water (H2O) to produce hydroxyl radicals (·OH) [21, 38].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [21]
Excited sonosensitizers release energy to oxygen, causing formation of reactive oxygen species such as superoxide anions and singlet oxygen.
“When the excited sonosensitizers return to the ground state, they can release energy to oxygen (O2), causing the formation of ROS, such as superoxide anions (·O2−) and singlet oxygen (1O2).”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [21]
Cites
Feng, Q., Yang, X., Hao, Y., Wang, N., Feng, X., Hou, L., & Zhang, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10948 · Cited by 155 · see citing works
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Tan, X., Huang, J., Wang, Y., He, S., Jia, L., Zhu, Y., Pu, K., Zhang, Y., & Yang, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202102703 · Cited by 262 · see citing works
Sonodynamic therapy-derived multimodal synergistic cancer therapy
Xu, M., Zhou, L., Zheng, L., Zhou, Q., Liu, K., Mao, Y., & Song, S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.10.037 · Cited by 211 · see citing works
Stimuli responsive nanosonosensitizers for sonodynamic therapy
Jiang, Z., Xiao, W., & Fu, Q. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.003 · Cited by 173 · see citing works
Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy
Zhu, Y., Li, Q., Wang, C., Hao, Y., Yang, N., Chen, M., Ji, J., Feng, L., & Liu, Z. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00822 · Cited by 163 · see citing works
Chen, H., Liu, L., Ma, A., Yin, T., Chen, Z., Liang, R., Qiu, Y., Zheng, M., & Cai, L. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120639 · Cited by 144 · see citing works
Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy
He, Z., Du, J., Miao, Y., & Li, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300234 · Cited by 105 · see citing works
Liu, L., Zhang, J., An, R., Xue, Q., Cheng, X., Hu, Y., Huang, Z., Wu, L., Zeng, W., Miao, Y., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202217055 · Cited by 96 · see citing works
Ferroptosis promotes sonodynamic therapy: a platinum( <scp>ii</scp> )–indocyanine sonosensitizer
Lai, Y., Lu, N., Ouyang, A., Zhang, Q., & Zhang, P. (2022) · Chemical Science · doi:10.1039/d2sc02597c · Cited by 91 · see citing works
Ultrasound-assisted tissue engineering
Melde, K., Athanassiadis, A. G., Missirlis, D., Shi, M., Seneca, S., & Fischer, P. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00166-5 · Cited by 59 · see citing works
Wang, T., Peng, W., Du, M., & Chen, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1167105 · Cited by 58 · see citing works
Nanosensitizer-assisted sonodynamic therapy for breast cancer
Yu, J., Hu, J.-R., Tian, Y., Lei, Y.-M., Hu, H.-M., Lei, B.-S., Zhang, G., Sun, Y., & Ye, H.-R. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03311-3 · Cited by 43 · see citing works
Zhang, C., Wu, J., Liu, W., Zhang, W., Lee, C., & Wang, P. (2022) · Small · doi:10.1002/smll.202202078 · Cited by 39 · see citing works
Self-citationGao, C., Kwong, C. H. T., Wang, Q., Kam, H., Wei, J., Chen, Q., Zhang, J., Lee, S. M. Y., Gu, D., & Wang, R. (2022) · Materials Today · doi:10.1016/j.mattod.2022.06.024 · Cited by 39 · see citing works
Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review
Hao, S., Shi, L., Li, J., Shi, J., Kuang, G., Liang, G., & Gao, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136738 · Cited by 7 · see citing works
- Authors
- Son, S., Kim, J. H., Wang, X., Zhang, C., Yoon, S. A., Shin, J., Sharma, A., Lee, M. H., Cheng, L., Wu, J., & Kim, J. S.
- Affiliations
- Korea University (KR)
- Soochow University (CN)
- Chinese Academy of Sciences (CN)
- Sookmyung Women's University (KR)
- Department of Chemistry
- Central Scientific Instruments Organisation (IN)
- Corresponding author
- Sharma, Amit
- Lee, Min Hee
- Cheng, Liang
- Wu, Jiasheng
- Kim, Jong Seung
- ORCID
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 49
- Issue
- 11
- Pages
- 3244-3261
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W3019242636
- Cited by
- 1,150
- References
- 1
- Citations by year
- 2026: 139 · 2025: 248 · 2024: 243 · 2023: 209 · 2022: 167 · 2021: 119 · 2020: 25
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2018R1C1B6006110, 2019H1A2A1074096)
- Department of Biotechnology, Ministry of Science and Technology (BT/RLF/Re-entry/59/2018)
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- National Natural Science Foundation of China (21673265)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- sonodynamic therapy, sonosensitizer, low-intensity ultrasound, cancer therapy, photodynamic therapy, photothermal therapy, combination therapy, drug delivery, tumor microenvironment, precision medicine
- MeSH terms
- Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Humans, Neoplasms, Photochemotherapy, Ultrasonic Therapy, Drug Delivery Systems, Photosensitizing Agents, Nanoparticles, Precision Medicine, Drug Liberation
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