The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Photobiomodulation (blue and green light) encourages osteoblastic-differentiation of human adipose-derived stem cells: role of intracellular calcium and light-gated ion channels
Open accessAbstract
Human adipose-derived stem cells (hASCs) have the potential to differentiate into several different cell types including osteoblasts. Photobiomodulation (PBM) or low level laser therapy (LLLT) using red or near-infrared wavelengths has been reported to have effects on both proliferation and osteogenic differentiation of stem cells. We examined the effects of delivering four different wavelengths (420 nm, 540 nm, 660 nm, 810 nm) at the same dose (3 J/cm 2) five times (every two days) on hASCs cultured in osteogenic medium over three weeks. We measured expression of the following transcription factors by RT-PCR: RUNX2, osterix and the osteoblast protein, osteocalcin. The 420 nm and 540 nm wavelengths were more effective in stimulating osteoblast differentiation compared to 660 nm and 810 nm. Intracellular calcium was higher after 420 nm and 540 nm and could be inhibited by capsazepine and SKF96365, which also inhibited osteogenic differentiation. We hypothesize that activation of light-gated calcium ion channels by blue and green light could explain our results.
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Bailes, H. J., & Lucas, R. J. (2013) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2012.2987 · Cited by 319
Cited by
Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation
Hamblin, M. R. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12864 · Cited by 820
Self-citationNon‐mammalian Hosts and Photobiomodulation: Do All Life‐forms Respond to Light?
Hamblin, M. R., Huang, Y., & Heiskanen, V. (2019) · Photochemistry and Photobiology · doi:10.1111/php.12951 · Cited by 58
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Metadata
- Authors
- Wang, Y., Huang, Y.-Y., Wang, Y., Lyu, P., & Hamblin, M. R.
- Venue
- Scientific Reports
- Published
- 2016-09-21
- Volume
- 6
- Issue
- 1
- Pages
- 33719-33719
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2521371484
- Cited by
- 221
- References
- 1
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- gold
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