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Cited by 820

The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.

Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

Open access
Hamblin, Michael R.·2018·Photochemistry and Photobiology
DOI 10.1111/php.12864
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Abstract

Photobiomodulation (PBM) involves the use of red or near‐infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones, and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria and, more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO, thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat‐gated ion channels. This review will cover the redox signaling that occurs in PBM and examine the difference between healthy and stressed cells, where PBM can have apparently opposite effects. PBM has a marked effect on stem cells, and this is proposed to operate via mitochondrial redox signaling. PBM can act as a preconditioning regimen and can interact with exercise on muscles.

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Metadata

Authors
Hamblin, M. R.
Venue
Photochemistry and Photobiology
Publisher
Wiley
Published
2018-01-19
Volume
94
Issue
2
Pages
199-212
ISSN
  • 0031-8655 (ISSN-L)
  • 1751-1097
DOI
10.1111/php.12864
OpenAlex
W2768877461
Cited by
820
References
119
FWCI
23.67
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. https://app.cochat.ai/papers/10.1111/php.12864
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Hamblin, M. R. (2018). Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochemistry and Photobiology. https://doi.org/10.1111/php.12864

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.