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Cited by 23Osteoarthritis Treatment and MechanismsKnee injuries and reconstruction techniquesHip disorders and treatments

Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis: Data from the Osteoarthritis Initiative (OAI)

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Wirth, W., Maschek, S., Roemer, F.W., Eckstein, F.·2016·Scientific Reports
DOI 10.1038/srep34202PMC PMC5037443
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Abstract

Magnetic resonance imaging (MRI)-based spin-spin relaxation time (T2) mapping has been shown to be associated with cartilage matrix composition (hydration, collagen content & orientation). To determine the impact of early radiographic knee osteoarthritis (ROA) and ROA risk factors on femorotibial cartilage composition, we studied baseline values and one-year change in superficial and deep cartilage T2 layers in 60 subjects (age 60.6 ± 9.6 y; BMI 27.8 ± 4.8) with definite osteophytes in one knee (earlyROA, n = 32) and with ROA risk factors in the contralateral knee (riskROA, n = 28), and 89 healthy subjects (age 55.0 ± 7.5 y; BMI 24.4 ± 3.1) without signs or risk factors of ROA. Baseline T2 did not differ significantly between earlyROA and riskROA knees in the superficial (48.0 ± 3.5 ms vs. 48.1 ± 3.1 ms) or the deep layer (37.3 ± 2.5 ms vs. 37.3 ± 1.8 ms). However, healthy knees showed significantly lower superficial layer T2 (45.4 ± 2.3 ms) than earlyROA or riskROA knees (p ≤ 0.001) and significantly lower deep layer T2 (35.8 ± 1.8 ms) than riskROA knees (p = 0.006). Significant longitudinal change in T2 (superficial: 0.5 ± 1.4 ms; deep: 0.8 ± 1.3 ms) was only detected in healthy knees. These results do not suggest an association of early ROA (osteophytes) with cartilage composition, as assessed by T2 mapping, whereas cartilage composition was observed to differ between knees with and without ROA risk factors.

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  • T2 mapping enables pre-morphological cartilage degradation detection.

    “Technical implementations produce parametric maps by means of multi-echo spin-echo sequences followed by signal decay curve fitting, so enabling pre-morphological cartilage degradation detection [60].”

    From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [60]

    The Methods (T2 analysis of femorotibial cartilage; page unavailable) describe multi-echo imaging and voxelwise signal-decay fitting. The Abstract reports T2 differences between healthy knees and knees with osteoarthritis risk factors, consistent with sensitivity to early compositional differences. But the Discussion says cartilage lesion scores were unavailable for the studied knees, so this paper does not establish detection of degradation before morphological changes. (LLM, conf=0.85)

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Authors
Wirth, W., Maschek, S., Roemer, F. W., & Eckstein, F.
Affiliations
  • Paracelsus Medical University (AT)
  • Boston University (US)
Corresponding author
Wirth, W.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-09-27
Volume
6
Issue
1
Pages
34202-34202
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep34202
PMC
PMC5037443
OpenAlex
W2527123381
Cited by
23
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 1 · 2016: 1
FWCI
3.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Foundation for the National Institutes of Health ((N01-AR-2-2258)
  • U.S. Department of Health and Human Services (N01-AR-2-2258, N01-AR-2-2261, N01-AR-2-2262, N01-AR-2-2259, N01-AR-2-2260)
  • Pfizer (N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262)
  • GlaxoSmithKline (N01‐AR‐2‐2261, N01-AR-2-2258, N01-AR-2-2260, N01-AR-2-2259, N01-AR-2-2262)
  • Novartis Pharmaceuticals Corporation (N01-AR-2-2261, N01-AR-2-2262, N01-AR-2-2260, N01-AR-2-2258, N01-AR-2-2259)
  • Bundesministerium für Bildung und Forschung (N01-AR-2-2260, N01-AR-2-2258, N01-AR-2-2261, N01-AR-2-2262, N01-AR-2-2259, 01EC1408D)
  • National Institutes of Health (N01 AR‐2‐2260, N01-AR-2-2258,N01-AR-2-2259,N01-AR-2-2260,N01-AR-2-2261,N01-AR-2-2262, N01-AR-2-2258, N01‐AR‐2‐2259, N01-AR-2-2261, N01-AR-2-2262)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords
knee osteoarthritis, femorotibial cartilage, T2 relaxation time, cartilage composition, collagen, osteophytes, osteoarthritis risk factors, Osteoarthritis Initiative

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