Systematic review and meta-analysis of the reliability and discriminative validity of cartilage compositional MRI in knee osteoarthritis

MacKay, J.W.; Low, S.B.L.; Smith, T.O.; Toms, A.P.; McCaskie, A.W.; Gilbert, F.J.

doi:10.1016/j.joca.2017.11.018

Cited by 148Osteoarthritis Treatment and MechanismsKnee injuries and reconstruction techniquesHip disorders and treatments

Systematic review and meta-analysis of the reliability and discriminative validity of cartilage compositional MRI in knee osteoarthritis

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MacKay, J.W., Low, S.B.L., Smith, T.O., Toms, A.P., McCaskie, A.W., Gilbert, F.J.·2018·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2017.11.018

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Abstract

Objective To assess reliability and discriminative validity of cartilage compositional magnetic resonance imaging (MRI) in knee osteoarthritis (OA). Design The study was carried out per PRISMA recommendations. We searched MEDLINE and EMBASE (1974 - present) for eligible studies. We performed qualitative synthesis of reliability data. Where data from at least two discrimination studies were available, we estimated pooled standardized mean difference (SMD) between subjects with and without OA. Discrimination analyses compared controls and subjects with mild OA (Kellgren-Lawrence (KL) grade 1-2), severe OA (KL grade 3-4) and OA not otherwise specified (NOS) where not possible to stratify. We assessed quality of the evidence using Quality Appraisal of Diagnostic Reliability (QAREL) and Quality Assessment of Diagnostic Accuracy (QUADAS-2) tools. Results Fifty-eight studies were included in the reliability analysis and 26 studies were included in the discrimination analysis, with data from a total of 2,007 knees. Intra-observer, inter-observer and test-retest reliability of compositional techniques were excellent with most intraclass correlation coefficients >0.8 and coefficients of variation <10%. T1rho and T2 relaxometry were significant discriminators between subjects with mild OA and controls, and between subjects with OA (NOS) and controls (P < 0.001). T1rho showed best discrimination for mild OA (SMD [95% CI] = 0.73 [0.40 to 1.06], P < 0.001) and OA (NOS) (0.60 [0.41 to 0.80], P < 0.001). Quality of evidence was moderate for both parts of the review. Conclusions Cartilage compositional MRI techniques are reliable and, in the case of T1rho and T2 relaxometry, can discriminate between subjects with OA and controls.

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Integration of T2 mapping with other quantitative MRI techniques such as T1rho, DTI, and sodium imaging enhances early compositional changes.
“Early compositional changes are enhanced by integration with other quantitative MRI techniques (e.g., T1rho, DTI, sodium imaging) [62].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [62]

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Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0 T in patients with early stage osteoarthritis
van Tiel, J., Bron, E. E., Tiderius, C. J., Bos, P. K., Reijman, M., Klein, S., Verhaar, J. A. N., Krestin, G. P., Weinans, H., Kotek, G., et al. (2012) · European Radiology · doi:10.1007/s00330-012-2616-x · Cited by 44 · see citing works
T1ρ and T2 quantitative magnetic resonance imaging analysis of cartilage regeneration following microfracture and mosaicplasty cartilage resurfacing procedures
Holtzman, D. J., Theologis, A. A., Carballido‐Gamio, J., Majumdar, S., Li, X., & Benjamin, C. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22300 · Cited by 43 · see citing works
T1ρ is superior to T2 mapping for the evaluation of articular cartilage denaturalization with osteoarthritis: Radiological–pathological correlation after total knee arthroplasty
Takayama, Y., Hatakenaka, M., Tsushima, H., Okazaki, K., Yoshiura, T., Yonezawa, M., Nishikawa, K., Iwamoto, Y., & Honda, H. (2012) · European Journal of Radiology · doi:10.1016/j.ejrad.2012.11.031 · Cited by 42 · see citing works
Repeatability of T1‐quantification in dGEMRIC for three different acquisition techniques: Two‐dimensional inversion recovery, three‐dimensional look locker, and three‐dimensional variable flip angle
Siversson, C., Tiderius, C. J., Neuman, P., Dahlberg, L., & Svensson, J. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22159 · Cited by 39 · see citing works
A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage
Juráš, V., Bohndorf, K., Heule, R., Kronnerwetter, C., Szomolányi, P., Hager, B., Bieri, O., Zbýň, Š., & Trattnig, S. (2015) · European Radiology · doi:10.1007/s00330-015-3979-6 · Cited by 37 · see citing works
Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T
Liu, F., Choi, K. W., Samsonov, A. A., Spencer, R. G. S., Wilson, J. J., Block, W. F., & Kijowski, R. (2015) · Radiology · doi:10.1148/radiol.2015142201 · Cited by 36 · see citing works
Reproducibility of sodium MRI measures of articular cartilage of the knee in osteoarthritis
Newbould, R. D., Miller, S. R., Tielbeek, J. A. W., Toms, L., Rao, A. W., Gold, G. E., Strachan, R. K., Taylor, P. C., Matthews, P. M., & Brown, A. P. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.10.007 · Cited by 34 · see citing works
Delayed contrast‐enhanced MRI of cartilage: Comparison of nonionic and ionic contrast agents
Li, W., Scheidegger, R., Wu, Y. G., Edelman, R. R., Farley, M. L., Krishnan, N., Burstein, D., & Prasad, P. V. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22555 · Cited by 34 · see citing works
Feasibility of in vivo diffusion tensor imaging of articular cartilage with coverage of all cartilage regions
Raya, J. G., Dettmann, E., Notohamiprodjo, M., Krasnokutsky, S., Abramson, S. B., & Gläser, C. (2014) · European Radiology · doi:10.1007/s00330-014-3155-4 · Cited by 33 · see citing works
Association between delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and joint space narrowing and osteophytes: a cohort study in patients with partial meniscectomy with 11 years of follow-up
Owman, H., Ericsson, Y. B., Englund, M., Tiderius, C. J., Tjörnstrand, J., Roos, E. M., & Dahlberg, L. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.02.929 · Cited by 32 · see citing works
Radiofrequency (RF) coil impacts the value and reproducibility of cartilage spin–spin (T2) relaxation time measurements
Dardzinski, B. J., & Schneider, E. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.01.006 · Cited by 32 · see citing works
Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping
Nishioka, H., Hirose, J., Nakamura, E., Okamoto, N., Karasugi, T., Taniwaki, T., Okada, T., Yamashita, Y., & Mizuta, H. (2013) · European Journal of Radiology · doi:10.1016/j.ejrad.2013.04.038 · Cited by 32 · see citing works
T2 values of articular cartilage in clinically relevant subregions of the asymptomatic knee
Surowiec, R. K., Lucas, E. P., Fitzcharles, E. K., Petre, B. M., Dornan, G. J., Giphart, J. E., LaPrade, R. F., & Ho, C. P. (2013) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-013-2779-2 · Cited by 31 · see citing works
Spatial variation inT1of healthy human articular cartilage of the knee joint
Wiener, E., Pfirrmann, C. W. A., & Hodler, J. (2010) · British Journal of Radiology · doi:10.1259/bjr/62779246 · Cited by 31 · see citing works
T1-Weighted Sodium MRI of the Articulator Cartilage in Osteoarthritis: A Cross Sectional and Longitudinal Study
Newbould, R. D., Miller, S. R., Upadhyay, N., Rao, A. W., Swann, P., Gold, G. E., Strachan, R. K., Matthews, P. M., Taylor, P. C., & Brown, A. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073067 · Cited by 30 · see citing works
Quantitative T2* assessment of knee joint cartilage after running a marathon
Hesper, T., Miese, F. R., Hosalkar, H. S., Behringer, M., Zilkens, C., Antoch, G., Krauspe, R., & Bittersohl, B. (2014) · European Journal of Radiology · doi:10.1016/j.ejrad.2014.11.021 · Cited by 29 · see citing works
Improved differentiation between knees with cartilage lesions and controls using 7T relaxation time mapping
Wyatt, C. R., Guha, A., Venkatachari, A., Li, X., Krug, R., Kelley, D. E., Link, T. M., & Majumdar, S. (2015) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2015.05.003 · Cited by 28 · see citing works
MR T1ρ quantification of cartilage focal lesions in acutely injured knees: correlation with arthroscopic evaluation
Gupta, R., Virayavanich, W., Kuo, D. Z., Su, F., Link, T. M., Ma, B., & Li, X. (2014) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2014.07.015 · Cited by 28 · see citing works
Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis: Data from the Osteoarthritis Initiative (OAI)
Wirth, W., Maschek, S., Roemer, F. W., & Eckstein, F. (2016) · Scientific Reports · doi:10.1038/srep34202 · Cited by 23 · see citing works
Glycosaminoglycan chemical exchange saturation transfer at 3T MRI in asymptomatic knee joints
Schleich, C., Bittersohl, B., Miese, F. R., Schmitt, B., Müller‐Lutz, A., Sondern, M., Antoch, G., Krauspe, R., & Zilkens, C. (2015) · Acta Radiologica · doi:10.1177/0284185115598811 · Cited by 22 · see citing works
Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge
Athelogou, M., Kim, H. J., Dima, A. A., Obuchowski, N. A., Peskin, A. P., Gavrielides, M. A., Petrick, N., Saiprasad, G., Colditz, D. C., Beaumont, H., et al. (2016) · Academic Radiology · doi:10.1016/j.acra.2016.02.018 · Cited by 21 · see citing works
The repeatability of T2 relaxation time measurement of human knee articular cartilage
Hannila, I., Lammentausta, E., Tervonen, O. A., & Nieminen, M. T. (2015) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-015-0494-3 · Cited by 21 · see citing works
Bone and cartilage characteristics in postmenopausal women with mild knee radiographic osteoarthritis and those without radiographic osteoarthritis.
Multanen, J., Heinonen, A. O., HÄKKINEN, A. H., Kautiainen, H., Kujala, U. M., Lammentausta, E., Jämsä, T. J., Kiviranta, I., & Nieminen, M. T. (2015) · PubMed Central · Cited by 20 · see citing works
Evaluation of the relationship between T 1 ρ and T 2 values and patella cartilage degeneration in patients of the same age group
Nishioka, H., Hirose, J., Okamoto, N., Okada, T., Oka, K., Taniwaki, T., Nakamura, E., Yamashita, Y., & Mizuta, H. (2014) · European Journal of Radiology · doi:10.1016/j.ejrad.2014.11.015 · Cited by 18 · see citing works
Cross-relaxation imaging of human patellar cartilage in vivo at 3.0T
Sritanyaratana, N., Samsonov, A. A., Mossahebi, P., Wilson, J. J., Block, W. F., & Kijowski, R. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.06.004 · Cited by 15 · see citing works
Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis
Guha, A., Wyatt, C. R., Karampinos, D. C., Nardo, L., Link, T. M., & Majumdar, S. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2015.06.004 · Cited by 13 · see citing works
Detection of early cartilage deterioration associated with meniscal tear using T1ρ mapping magnetic resonance imaging
Matsubara, H., Okazaki, K., Takayama, Y., Osaki, K., Matsuo, Y., Honda, H., & Iwamoto, Y. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0487-4 · Cited by 11 · see citing works
Integration of accelerated MRI and post-processing software: a promising method for studies of knee osteoarthritis
Duryea, J., Cheng, C., Schaefer, L. F., Smith, S. E., & Madore, B. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.06.001 · Cited by 6 · see citing works

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Imaging in Osteoarthritis
Roemer, F. W., Guermazi, A., Demehri, S., Wirth, W., & Kijowski, R. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.04.018 · Cited by 146 · see citing works
MRI T2 and T1ρ relaxation in patients at risk for knee osteoarthritis: a systematic review and meta-analysis
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The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage
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Imaging of knee osteoarthritis: a review of multimodal diagnostic approach
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The relation between the biochemical composition of knee articular cartilage and quantitative MRI: a systematic review and meta-analysis
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Quantitative MRI for Evaluation of Musculoskeletal Disease
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Use of Computational Modeling to Study Joint Degeneration: A Review
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Imaging of knee osteoarthritis: A review of current evidence and clinical guidelines
Lee, L. S., Ping Keung, C. H. A. N., Fung, W. C., Chan, V. W. K., Yan, C. H., & Chiu, P. (2021) · Musculoskeletal Care · doi:10.1002/msc.1536 · Cited by 57 · see citing works
Knee MRI Underestimates the Grade of Cartilage Lesions
Krakowski, P., Karpiński, R., Jojczuk, M., Nogalska, A., & Jonak, J. (2021) · Applied Sciences · doi:10.3390/app11041552 · Cited by 49 · see citing works
Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage
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MRI T2 Mapping of the Knee Providing Synthetic Morphologic Images: Comparison to Conventional Turbo Spin-Echo MRI
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High tibial osteotomy to neutral alignment improves medial knee articular cartilage composition
Atkinson, H. F., Birmingham, T. B., Schulz, J. M., Primeau, C. A., Leitch, K. M., Pritchett, S., Holdsworth, D. W., & Giffin, J. R. (2021) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-021-06516-9 · Cited by 44 · see citing works
The effects of weight loss on imaging outcomes in osteoarthritis of the hip or knee in people who are overweight or obese: a systematic review
Daugaard, C. L., Hangaard, S., Bartels, E. M., Gudbergsen, H., Christensen, R., Bliddal, H., Englund, M., Conaghan, P. G., & Boesen, M. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.10.013 · Cited by 41 · see citing works
Updates on Compositional MRI Mapping of the Cartilage: Emerging Techniques and Applications
Zibetti, M. V. W., Menon, R. G., de Moura, H. L., Zhang, X., Kijowski, R., & Regatte, R. R. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28689 · Cited by 40 · see citing works
High-Impact Exercise Increased Femoral Neck Bone Density With No Adverse Effects on Imaging Markers of Knee Osteoarthritis in Postmenopausal Women
Hartley, C., Folland, J. P., Kerslake, R. W., & Brooke-Wavell, K. S. F. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3867 · Cited by 39 · see citing works
Correlations between radiological classification systems and confirmed cartilage loss in severe knee osteoarthritis
Keenan, O. J. F., Holland, G., Maempel, J. F., Keating, J. F., & Scott, C. E. H. (2020) · The Bone & Joint Journal · doi:10.1302/0301-620x.102b3.bjj-2019-0337.r1 · Cited by 37 · see citing works
New advances in MRI diagnosis of degenerative osteoarthropathy of the peripheral joints
Bruno, F., Arrigoni, F., Palumbo, P., Natella, R., Maggialetti, N., Reginelli, A., Splendiani, A., Cesare, E. D., Brunese, L., Guglielmi, G., et al. (2019) · La radiologia medica · doi:10.1007/s11547-019-01003-1 · Cited by 35 · see citing works
Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis diagnosis and prognosis
Martel‐Pelletier, J., Paiement, P., & Pelletier, J. (2023) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x231165560 · Cited by 35 · see citing works
Imaging of early-stage osteoarthritis: the needs and challenges for diagnosis and classification
Oei, E. H. G., & Runhaar, J. (2023) · Skeletal Radiology · doi:10.1007/s00256-023-04355-y · Cited by 35 · see citing works
Early knee OA definition–what do we know at this stage? An imaging perspective
Li, X., Roemer, F. W., Cicuttini, F., MacKay, J. W. B., Turmezei, T. D., & Link, T. M. (2023) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x231158204 · Cited by 32 · see citing works
Self-citation
Chondrocalcinosis of the Knee and the Risk of Osteoarthritis Progression: Data From the Knee and Hip Osteoarthritis Long‐term Assessment Cohort
Latourte, A., Rat, A., Sime, W. N., Ea, H., Bardin, T., Mazières, B., Roux, C. H., Guillemin, F., & Richette, P. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41186 · Cited by 31 · see citing works
Leg length discrepancy: A systematic review on the validity and reliability of clinical assessments and imaging diagnostics used in clinical practice
Alfuth, M., Fichter, P., & Knicker, A. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261457 · Cited by 28 · see citing works
SuperMAP: Deep ultrafast MR relaxometry with joint spatiotemporal undersampling
Li, H., Yang, M., Kim, J. J., Zhang, C., Liu, R., Huang, P., Liang, D., Zhang, X., Li, X., & Ying, L. L. (2022) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29411 · Cited by 27 · see citing works
Application of quantitative T1, T2 and T2* mapping magnetic resonance imaging in cartilage degeneration of the shoulder joint
Cao, G., Shubo, G., & Xiong, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-31644-2 · Cited by 25 · see citing works
Current status of functional MRI of osteoarthritis for diagnosis and prognosis
Juráš, V., Chang, G. A., & Regatte, R. R. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000674 · Cited by 24 · see citing works
Three‐Dimensional Surface‐Based Analysis of Cartilage MRI Data in Knee Osteoarthritis: Validation and Initial Clinical Application
Mackay, J., Kaggie, J. D., Treece, G. M., McDonnell, S., Khan, W. S., Roberts, A. R., Janiczek, R. L., Graves, M. J., Turmezei, T. D., McCaskie, A. W., et al. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27193 · Cited by 24 · see citing works
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Establishing compositional MRI of cartilage as a biomarker for clinical practice
Link, T. M., & Li, X. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.02.902 · Cited by 24 · see citing works
2D versus 3D MRI of osteoarthritis in clinical practice and research
Walter, S. S., Fritz, B., Kijowski, R., & Fritz, J. M. (2023) · Skeletal Radiology · doi:10.1007/s00256-023-04309-4 · Cited by 23 · see citing works
Segmentation of knee MRI data with convolutional neural networks for semi-automated three-dimensional surface-based analysis of cartilage morphology and composition
Kessler, D. A., Mackay, J., McDonnell, S., Janiczek, R. L., Graves, M. J., Kaggie, J. D., & Gilbert, F. J. (2022) · Osteoarthritis Imaging · doi:10.1016/j.ostima.2022.100010 · Cited by 22 · see citing works
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Effectively Measuring Exercise‐Related Variations in T1ρ and T2 Relaxation Times of Healthy Articular Cartilage
Kessler, D. A., Mackay, J., McDonald, S., McDonnell, S., Grainger, A. J., Roberts, A. R., Janiczek, R. L., Graves, M. J., Kaggie, J. D., & Gilbert, F. J. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27278 · Cited by 22 · see citing works
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Rapid compositional mapping of knee cartilage with compressed sensing MRI
Zibetti, M. V. W., Baboli, R., Chang, G. A., Otazo, R., & Regatte, R. R. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26274 · Cited by 21 · see citing works
Cartilage compositional MRI—a narrative review of technical development and clinical applications over the past three decades
Li, X., Kim, J., Yang, M., Ok, A. H., Zbýň, Š., Link, T. M., Majumdar, S., Benjamin, C., Spindler, K. P., & Winalski, C. S. (2024) · Skeletal Radiology · doi:10.1007/s00256-024-04734-z · Cited by 21 · see citing works
Quantitative Cartilage T2 and T1rho Mapping: Is There a Clinical Role? From the AJR Special Series on Quantitative Imaging
Mosher, T. J. (2024) · American Journal of Roentgenology · doi:10.2214/ajr.24.31655 · Cited by 21 · see citing works
Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment
Kumar, R. R., Sporn, K., Paladugu, P., Khanna, A., Gowda, C., Ngo, A., Waisberg, E., Ong, J., Jagadeesan, R., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15131648 · Cited by 21 · see citing works
Quantitative evaluation of the tibiofemoral joint cartilage by T2 mapping in patients with acute anterior cruciate ligament injury vs contralateral knees: results from the subacute phase using data from the NACOX study cohort
Casula, V., Tajik, B., Kvist, J., Frobell, R. B., Haapea, M., Nieminen, M. T., Gauffin, H., & Englund, M. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.02.623 · Cited by 21 · see citing works
Setting up distinctive outcome measures for each osteoarthritis phenotype
Roman‐Blas, J. A., Mendoza-Torres, L. A., Largo, R., & Herrero‐Beaumont, G. (2020) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x20937966 · Cited by 21 · see citing works
Optimization of spin‐lock times in T1ρ mapping of knee cartilage: Cramér‐Rao bounds versus matched sampling‐fitting
Zibetti, M. V. W., Sharafi, A., & Regatte, R. R. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29063 · Cited by 21 · see citing works
Defective WNT signaling may protect from articular cartilage deterioration – a quantitative MRI study on subjects with a heterozygous WNT1 mutation
Lehtovirta, S., Mäkitie, R. E., Casula, V., Haapea, M., Niinimäki, J. L., Niinimäki, T., Peuna, A., Lammentausta, E., Mäkitie, O., & Nieminen, M. T. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.07.001 · Cited by 20 · see citing works
Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial
Freitag, J., Chamberlain, M. D., Wickham, J. B., Shah, K., Cicuttini, F., Wang, Y., Solterbeck, A., Kenihan, L., Kelly, L.-A., Castelluccio, R., et al. (2024) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2024.100500 · Cited by 18 · see citing works
Baseline cartilage T1ρ and T2 predicted patellofemoral joint cartilage lesion progression and patient‐reported outcomes after ACL reconstruction
Xie, D., Tanaka, M. S., Pedoia, V., Li, A., Facchetti, L., Neumann, J., Lartey, R., Souza, R. B., Link, T. M., Benjamin, C., et al. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25473 · Cited by 18 · see citing works
Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis
Coburn, S., Crossley, K. M., Kemp, J. L., Warden, S. J., West, T., Bruder, A. M., Mentiplay, B. F., & Culvenor, A. G. (2023) · Sports Medicine - Open · doi:10.1186/s40798-023-00602-7 · Cited by 18 · see citing works
Rapid mono and biexponential 3D-T1ρ mapping of knee cartilage using variational networks
Zibetti, M. V. W., Johnson, P. M., Sharafi, A., Hammernik, K., Knöll, F., & Regatte, R. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-76126-x · Cited by 18 · see citing works
Towards Patient-Specific Computational Modelling of Articular Cartilage on the Basis of Advanced Multiparametric MRI Techniques
Linka, K., Schäfer, A., Hillgärtner, M., Itskov, M., Knobe, M., Kuhl, C. K., Hitpaß, L., Truhn, D., Thüring, J., & Nebelung, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-43389-y · Cited by 17 · see citing works
A multi-purpose force-controlled loading device for cartilage and meniscus functionality assessment using advanced MRI techniques
Truhn, D., Brill, N., Braun, B. J., Merhof, D., Kuhl, C. K., Knobe, M., Thüring, J., & Nebelung, S. (2019) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2019.103428 · Cited by 17 · see citing works
Accelerated mono‐ and biexponential 3D‐T1ρ relaxation mapping of knee cartilage using golden angle radial acquisitions and compressed sensing
Zibetti, M. V. W., Sharafi, A., Otazo, R., & Regatte, R. R. (2019) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28019 · Cited by 17 · see citing works
Multi-vendor multi-site quantitative MRI analysis of cartilage degeneration 10 Years after anterior cruciate ligament reconstruction: MOON-MRI protocol and preliminary results
Xie, D., Murray, J., Lartey, R., Gaj, S., Kim, J. J., Li, M., Eck, B., Winalski, C. S., Altahawi, F. F., Jones, M. H., et al. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.08.006 · Cited by 16 · see citing works
Reproducibility of T1ρ and T2 quantification in a multi-vendor multi-site study
Lartey, R., Nanavati, A. K., Kim, J. J., Li, M., Xu, K., Nakamura, K., Shin, W., Winalski, C. S., Obuchowski, N. A., Bahroos, E., et al. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.10.017 · Cited by 16 · see citing works
Age‐Dependent Changes in Knee Cartilage T1 , T2 , and T1 p Simultaneously Measured Using MRI Fingerprinting
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Authors: MacKay, J. W., Low, S. B. L., Smith, T. O., Toms, A. P., McCaskie, A. W., & Gilbert, F. J.
Affiliations: University of Cambridge (GB)
Norfolk and Norwich University Hospital (GB)
University of East Anglia (GB)
Corresponding author: MacKay, J.W.
Low, S.B.L.
Smith, T.O.
Toms, A.P.
McCaskie, A.W.
Gilbert, F.J.
ORCID: MacKay, J.W.
Smith, T.O.
Toms, A.P.
McCaskie, A.W.
Gilbert, F.J.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2018-09
Volume: 26
Issue: 9
Pages: 1140-1152
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2017.11.018
OpenAlex: W2769705592
Cited by: 148
References: 97
Citations by year: 2026: 13 · 2025: 18 · 2024: 18 · 2023: 29 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 19 · 2018: 3
FWCI: 2.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (acceptedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by)
Apollo (cc-by)
Funders: National Institute for Health Research Cambridge Biomedical Research Centre
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords: knee osteoarthritis, T2 relaxometry, diagnostic accuracy, inter-rater reliability, test-retest reliability, cartilage composition, Kellgren-Lawrence grade
MeSH terms: Aged, Cartilage, Articular, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Reproducibility of Results, Case-Control Studies, Osteoarthritis, Knee

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Systematic review and meta-analysis of the reliability and discriminative validity of cartilage compositional MRI in knee osteoarthritis

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