Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state

Trevelin, Silvia Cellone; dos Santos, Célio Xavier; Ferreira, Raphael Gomes; de Sá Lima, Larissa; Silva, Rangel Leal; Scavone, Cristoforo; Curi, Rui; Alves-Filho, José Carlos; Cunha, Thiago Mattar; Roxo-Júnior, Pérsio; Cervi, Maria-Célia; Laurindo, Francisco Rafael Martins; Hothersall, John Stephen; Cobb, Andrew M.; Zhang, Min; Ivetic, Aleksandar; Shah, Ajay M.; Lopes, Lucia Rossetti; Cunha, Fernando Queiroz

doi:10.1038/srep34581

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state

The reactive-oxygen-species-(ROS)-generating-enzyme Nox2 is essential for leukocyte anti-microbial activity. However its role in cellular redox homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear. Herein, we show Nox2 activation favors thioredoxin-1 (TRX-…