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Cited by 90Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesRedox biology and oxidative stress

A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes

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Allhorn, Maria, Arve, Sabine, Brüggemann, Holger, Lood, Rolf·2016·Scientific Reports
DOI 10.1038/srep36412PMC PMC5090349
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Abstract

The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for r adical ox ygenase of P ropionibacterium acnes . RoxP is uniquely produced by the predominant skin bacterium P. acnes , with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxidation. Strikingly, RoxP is crucial for the survival of P. acnes in oxic conditions and for skin colonization of P. acnes ex vivo . Taken together, our study strongly suggests that RoxP facilitates P. acnes ’ survival on human skin, and is an important beneficial factor for the host-commensal interaction. Thus, RoxP is the first described skin microbiota-derived mutualistic factor that potentially can be exploited for human skin protection.

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Cited by

Sorted by citations

Authors
Allhorn, M., Arve, S., Brüggemann, H., & Lood, R.
Affiliations
  • Lund University (SE)
  • Aarhus University (DK)
Corresponding author
Lood, Rolf
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-11-02
Volume
6
Issue
1
Pages
36412-36412
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep36412
PMC
PMC5090349
OpenAlex
W2548591662
Cited by
90
References
1
Citations by year
2026: 7 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 11 · 2020: 4 · 2019: 11 · 2018: 8 · 2017: 4
FWCI
9.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Lunds Universitet
  • Kungliga Fysiografiska Sällskapet i Lund
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
Propionibacterium acnes, antioxidant enzymes, skin microbiome, skin colonization, heme binding, free radical scavenging, oxidative stress resistance, skin protection
MeSH terms
Antioxidants, Bacterial Proteins, Heme, Humans, Oxidation-Reduction, Oxygenases, Phylogeny, Propionibacterium acnes, Protein Binding, RNA, Bacterial, Skin, Mutagenesis, Sequence Analysis, RNA, Microbiota

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