The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
Open accessAbstract
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC 50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins αvβ3, αvβ5, αvβ6, αvβ8, α5β1, αIIbβ3, using homogenous ELISA-like solid phase binding assay.
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Exploring the Role of RGD-Recognizing Integrins in Cancer
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Self-citationFertala, A. (2020) · Bioengineering · doi:10.3390/bioengineering7040155 · Cited by 109
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
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Cell adhesion molecules in fibrotic diseases
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Metadata
- Authors
- Kapp, T. G., Rechenmacher, F., Neubauer, S., Maltsev, O. V., Cavalcanti-Adam, E. A., Zarka, R., Reuning, U., Notni, J., Wester, H.-J., Mas-Moruno, C., Spatz, J., Geiger, B., & Kessler, H.
- Venue
- Scientific Reports
- Published
- 2017-01-11
- Volume
- 7
- Issue
- 1
- Pages
- 39805-39805
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2578530566
- Cited by
- 620
- References
- 89
- FWCI
- 34.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kapp, T. G., Rechenmacher, F., Neubauer, S., Maltsev, O. V., Cavalcanti-Adam, E. A., Zarka, R., Reuning, U., Notni, J., Wester, H.-J., Mas-Moruno, C., Spatz, J., Geiger, B., & Kessler, H. (2017). A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins. Scientific Reports. https://doi.org/10.1038/srep39805
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