Cited by 26Cardiomyopathy and Myosin StudiesThyroid Disorders and TreatmentsCardiac Imaging and Diagnostics

Free triiodothyronine level correlates with myocardial injury and prognosis in idiopathic dilated cardiomyopathy: evidence from cardiac MRI and SPECT/PET imaging

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Wang, Wenyao, Guan, Haixia, Fang, Wei, Zhang, Kuo, Gerdes, A. Martin, Iervasi, Giorgio, Tang, Yi-Da·2016·Scientific Reports

Abstract

Abstract Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by 99mTc-MIBI SPECT /18F-FDG PET imaging. Across the quartiles of FT3, decreased percentage of segments with LGE and perfusion/metabolism abnormalities were found. As for FT4 and TSH levels, no significant distribution trend of myocardial injuries could be detected. In logistic analysis, FT3 was independently associated with the presence of LGE (OR: 0.140, 95% CI: 0.035–0.567), perfusion abnormalities (OR: 0.172, 95% CI: 0.040–0.738) and metabolism abnormalities (OR: 0.281, 95% CI: 0.081–0.971). After a median follow-up of 46 months, LGE-positive and FT3 < 2.77 pg/mL was identified as the strongest predictor of cardiac events (HR: 8.623, 95% CI: 3.626–16.438). Low FT3 level is associated with myocardial fibrosis and perfusion/metabolism abnormalities in patients with IDCM. The combination of FT3 level and LGE provides useful information for assessing the prognosis of IDCM.

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  • Low serum triiodothyronine levels are associated with cardiac fibrosis in patients with idiopathic dilated cardiomyopathy.

    “is supported by the association of low serum T 3 levels with the presence of cardiac fibrosis in patients with idiopathic dilated cardiomyopathy (30).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [30]

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Authors
Wang, W., Guan, H., Fang, W., Zhang, K., Gerdes, A. M., Iervasi, G., & Tang, Y.-D.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • First Hospital of China Medical University (CN)
  • New York Institute of Technology (US)
  • Istituto di Fisiologia Clinica (IT)
Corresponding author
Tang, Yi-Da
Venue
Scientific Reports
Published
2016-12-22
Volume
6
Issue
1
Pages
39811-39811
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2566265692
Cited by
26
References
31
Citations by year
2026: 1 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 1
FWCI
2.20
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81470485)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
idiopathic dilated cardiomyopathy, free triiodothyronine, thyroid dysfunction, myocardial injury, myocardial fibrosis, late gadolinium enhancement, myocardial perfusion, myocardial metabolism, 99mTc-MIBI SPECT, 18F-FDG PET, prognosis, cardiac events
MeSH terms
Adult, Cardiomyopathy, Dilated, Contrast Media, Female, Follow-Up Studies, Gadolinium, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Prognosis, Prospective Studies, Triiodothyronine, Positron-Emission Tomography

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