Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control
Open accessAbstract
The yellow fever mosquito,Aedes aegypti, particularly in Neotropical regions, is the principal vector of dengue, yellow fever, Zika and Chikungunya viruses. Pyrethroids remain one of the most used insecticides to control Aedes mosquitoes, despite the development of pyrethroid resistance in many mosquito populations worldwide. Here, we report a Brazilian strain of A. aegypti with high levels (approximately 100–60,000 fold) of resistance to both type I and type II pyrethroids. We detected two mutations (V410L and F1534C) in the sodium channel from this resistant strain. This study is the first report of the V410L mutation in mosquitoes. Alone or in combination with the F1534C mutation, the V410L mutation drastically reduced the sensitivity of mosquito sodium channels expressed in Xenopus oocytes to both type I and type II pyrethroids. The V410L mutation presents a serious challenge for the control of A. aegypti and will compromise the use of pyrethroids for the control of A. aegypti in Brazil; therefore, early monitoring of the frequency of the V410L mutation will be a key resistance management strategy to preserve the effectiveness of pyrethroid insecticides.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In at least one study, kdr mutations were the more important mechanism of resistance to pyrethroids in adult Ae. aegypti.
“In at least one study, however, kdr mutations were the more important mechanism of resistance to pyrethroids in adult Ae. aegypti.[13]”
From Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes (2018) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,865 · see citing works
Comprehensive Molecular Insect Science
Gilbert, L. I., Iatrou, K., & Gill, S. S. (2025) · Elsevier eBooks · doi:10.1016/c2021-1-02770-5 · Cited by 1,712 · see citing works
The molecular basis of insecticide resistance in mosquitoes
Hemingway, J., Hawkes, N. J., McCarroll, L., & Ranson, H. (2004) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2004.03.018 · Cited by 1,117 · see citing works
Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions
Liu, N. (2015) · Annual Review of Entomology · doi:10.1146/annurev-ento-010814-020828 · Cited by 1,057 · see citing works
Ranson, H., & Lissenden, N. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2015.11.010 · Cited by 989 · see citing works
Robertson, J. L., Jones, M. M., Olguin, E., & Alberts, B. (2007) · CRC Press eBooks · doi:10.1201/9781315373775 · Cited by 879 · see citing works
Cytochromes P450 and insecticide resistance
Scott, J. G. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00038-7 · Cited by 775 · see citing works
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances
Soderlund, D. M. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0726-x · Cited by 646 · see citing works
Molecular biology of insect sodium channels and pyrethroid resistance
Dong, K., Du, Y., Rinkevich, F. D. L., Nomura, Y., Xu, P., Wang, L., Silver, K., & Zhorov, B. S. (2014) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2014.03.012 · Cited by 550 · see citing works
Self-citationOverview of Insecticide Resistance
Georghiou, G. P. (1990) · ACS symposium series · doi:10.1021/bk-1990-0421.ch002 · Cited by 470 · see citing works
Feyereisen, R. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00049-1 · Cited by 421 · see citing works
Smith, L. B., Kasai, S., & Scott, J. G. (2016) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2016.03.005 · Cited by 405 · see citing works
Diversity and convergence of sodium channel mutations involved in resistance to pyrethroids
Rinkevich, F. D. L., Du, Y., & Dong, K. (2013) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2013.02.007 · Cited by 327 · see citing works
Self-citationAn Overview of Insecticide Resistance
Hemingway, J., Field, L. M., & VONTAS, J. G. (2002) · Science · doi:10.1126/science.1078052 · Cited by 325 · see citing works
Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel
Du, Y., Nomura, Y., Satar, G., Hu, Z., Nauen, R., He, S. Y., Zhorov, B. S., & Dong, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305118110 · Cited by 324 · see citing works
Self-citationModelling insecticide-binding sites in the voltage-gated sodium channel
O’Reilly, A. O., Khambay, B. P. S., Williamson, M. S., Field, L. M., Wallace, B. A., & Davies, T. G. E. (2006) · Biochemical Journal · doi:10.1042/bj20051925 · Cited by 285 · see citing works
Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats
Devine, G. J., Perea, E. Z., Killeen, G. F., Stancil, J. D., Clark, S. J., & Morrison, A. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901369106 · Cited by 216 · see citing works
Functional Expression ofDrosophila paraSodium Channels
Warmke, J. W., Reenan, R. A., Wang, P., Qian, S., Arena, J. P., Wang, J., Wunderler, D., Liu, K., Kaczorowski, G. J., der Ploeg, L. H. T. V., et al. (1997) · The Journal of General Physiology · doi:10.1085/jgp.110.2.119 · Cited by 216 · see citing works
Feng, G., Deák, P., Chopra, M., & Hall, L. M. (1995) · Cell · doi:10.1016/0092-8674(95)90279-1 · Cited by 215 · see citing works
Assessing the Effects of Aedes aegypti kdr Mutations on Pyrethroid Resistance and Its Fitness Cost
Brito, L. P., Linss, J., Lima‐Camara, T. N., Belinato, T. A., Peixoto, A. A., Lima, J. B. P., Valle, D., & Martins, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060878 · Cited by 214 · see citing works
Jones, C. M., Liyanapathirana, M., Agossa, F. R., Weetman, D., Ranson, H., Donnelly, M. J., & Wilding, C. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201475109 · Cited by 206 · see citing works
Voltage-Gated Sodium Channels as Insecticide Targets
Silver, K., Du, Y., Nomura, Y., de Oliveira, E. E., Salgado, V. L., Zhorov, B. S., & Dong, K. (2014) · Advances in insect physiology · doi:10.1016/b978-0-12-417010-0.00005-7 · Cited by 183 · see citing works
Self-citationTatebayashi, H., & Narahashi, T. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22418-1 · Cited by 173 · see citing works
Hirata, K., Komagata, O., Itokawa, K., Yamamoto, A., Tomita, T., & Kasai, S. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003085 · Cited by 166 · see citing works
Activation ofDrosophilaSodium Channels Promotes Modification by Deltamethrin
Vais, H., Williamson, M. S., Goodson, S. J., DEVONSHIRE, A. L., Warmke, J. W., Usherwood, P. N. R., & Cohen, C. J. (2000) · The Journal of General Physiology · doi:10.1085/jgp.115.3.305 · Cited by 166 · see citing works
Linss, J., Brito, L. P., Garcia, G. A., Araki, A. S., Bruno, R. V., Lima, J. B. P., Valle, D., & Martins, A. J. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-25 · Cited by 164 · see citing works
Liu, N., Li, T., Reid, W. R., Yang, T., & Zhang, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023403 · Cited by 155 · see citing works
Davies, T. G. E., Field, L. M., Usherwood, P. N. R., & Williamson, M. S. (2007) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2007.00733.x · Cited by 145 · see citing works
Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
Tan, J., Liu, Z., Wang, R., Huang, Z., Chen, A. C., Gurevitz, M., & Dong, K. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.006205 · Cited by 137 · see citing works
Self-citationBellinato, D. F., Viana-Medeiros, P. F., Araújo, S. C., Martins, A. J., Lima, J. B. P., & Valle, D. (2016) · BioMed Research International · doi:10.1155/2016/8603263 · Cited by 101 · see citing works
State-dependent modification of voltage-gated sodium channels by pyrethroids
Soderlund, D. M. (2009) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2009.06.010 · Cited by 97 · see citing works
Hu, Z., Du, Y., Nomura, Y., & Dong, K. (2010) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2010.09.005 · Cited by 96 · see citing works
Self-citationChediak, M., Pimenta, F. G., Coelho, G. E., Braga, I. A., Lima, J. B. P., Cavalcante, K. R. L. J., de Sousa, L. C., de Melo-Santos, M. A. V., Macoris, M. D. L. D. G., de Araújo, A. P., et al. (2016) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150409 · Cited by 81 · see citing works
Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel
Zhorov, B. S., & Dong, K. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.08.013 · Cited by 71 · see citing works
Self-citationRanson, H., & Hemingway, J. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00074-0 · Cited by 56 · see citing works
Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel
Du, Y., Nomura, Y., Zhorov, B. S., & Dong, K. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098707 · Cited by 39 · see citing works
Self-citationde Oliveira, E. E., Du, Y., Nomura, Y., & Dong, K. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.06.001 · Cited by 34 · see citing works
Self-citationControl of Urban Zika Vectors: Should We Return to the Successful PAHO/WHO Strategy?
Reiter, P. L. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004769 · Cited by 28 · see citing works
Marriel, N. B., Tomé, H. V. V., Guedes, R. N. C., & Martins, G. F. (2016) · Acta Tropica · doi:10.1016/j.actatropica.2016.02.021 · Cited by 25 · see citing works
Self-citationDu, Y., Song, W., Groome, J. R., Nomura, Y., Luo, N., & Dong, K. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.05.016 · Cited by 23 · see citing works
Self-citationChapadense, F. G. G., Fernandes, É. K. K., Lima, J. B. P., Martins, A. J., Carrara, L., da Rocha, W. T., dos Santos, A. H., & Cravo, P. (2015) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0046-2015 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Araújo, A. P. Análise da resistência a inseticidas químicos em populações de Aedes aegypti (Diptera: Culicidae), de Municípios do Estado de Pernambuco PhD thesis, Fundação Oswaldo Cruz, Recife-PE, 120p (2013).
- Feyereisen R. In Comprehensive Molecular Insect Sciencevol. 4, Elsevier, Oxford, pp. 1– 77. (eds Gilbert L. I., Latrou K. & Gill S.) (2005).
- Ranson H. & Hemingway J. In Comprehensive Molecular Insect Science, vol. 5, Elsevier, Oxford, pp. 383– 402. (eds Gilbert L. I., Latrou K. & Gill S.) (2005).
- Warmke J. W.. Functional expression of Drosophila para sodium channels modulation by the membrane protein TipE and toxin pharmacology. The Journal of general physiology 110, 119– 133 (1997). 9236205 PMC2233785
Cited by
Sorted by citations
Bioremediation of Agricultural Soils Polluted with Pesticides: A Review
Raffa, C. M., & Chiampo, F. (2021) · Bioengineering · doi:10.3390/bioengineering8070092 · Cited by 219 · see citing works
Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: a review
Gan, S. J., Leong, Y. Q., bin Barhanuddin, M. F. H., Wong, S. T., Wong, S. F., Mak, J. W., & Ahmad, R. B. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04785-4 · Cited by 182 · see citing works
Saavedra-Rodríguez, K., Vera-Maloof, F. Z., Campbell, C. L., Garcia-Rejon, J. E., Lenhart, A. E., Penilla-Navarro, R. P., Rodríguez, A. D., Sandoval, A. A., Flores, A. E., Ponce‐García, G., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25222-0 · Cited by 131 · see citing works
Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use
Scott, J. G. (2019) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-112420 · Cited by 116 · see citing works
Estep, A. S., Sanscrainte, N. D., Waits, C. M., Bernard, S. J., Lloyd, A. M., Lucas, K. J., Buckner, E. A., Vaidyanathan, R., Morreale, R., Conti, L., et al. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006544 · Cited by 108 · see citing works
Marcombe, S., Fustec, B., Cattel, J., Chonephetsarath, S., Thammavong, P., Phommavanh, N., David, J., Corbel, V., Sutherland, I. W., Hertz, J. C., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007852 · Cited by 100 · see citing works
Ferreira, T. P., Haddi, K., Corrêa, R. F. T., Zapata, V. L. B., Piau, T. B., de Souza, L. F. N., Santos, S.-M. G., de Oliveira, E. E., Jumbo, L. O. V., Ribeiro, B. M., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007624 · Cited by 97 · see citing works
Self-citationBadolo, A., Sombié, A., Pignatelli, P. M., Sanon, A., Yameogo, F., Wangrawa, D. W., Sanon, A., Kanuka, H., McCall, P. J., & Weetman, D. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007439 · Cited by 90 · see citing works
Chen, M., Du, Y., Wu, S., Nomura, Y., Zhu, G., Zhorov, B. S., & Dong, K. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007432 · Cited by 79 · see citing works
Self-citationBowman, N. M., Akialis, K., Cave, G., Barrera, R., Apperson, C. S., & Meshnick, S. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196410 · Cited by 72 · see citing works
Fan, Y., O’Grady, P., Yoshimizu, M. H., Ponlawat, A., Kaufman, P. E., & Scott, J. G. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008154 · Cited by 72 · see citing works
Impact of the microbiome on mosquito-borne diseases
Shi, H., Yu, X., & Cheng, G. (2023) · Protein & Cell · doi:10.1093/procel/pwad021 · Cited by 71 · see citing works
Larvicidal effect of essential oils from Brazilian cultivars of guava on Aedes aegypti L.
Mendes, L. A., Martins, G. F., Valbon, W. R., de Souza, T. D. S., Menini, L., Ferreira, A., & Ferreira, M. F. D. S. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.07.034 · Cited by 70 · see citing works
Self-citationAyres, C. F. J., Seixas, G., Borrego, S., Marques, C., Monteiro, I. Q. D. R., Marques, C. S., de Gouveia, B. R. F. O., Leal, S. D. V., Troco, A. D., Fortes, F., et al. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008216 · Cited by 62 · see citing works
Luo, D.-Y., Yan, Z., Che, L.-R., Zhu, J., & Chen, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-09190-0 · Cited by 63 · see citing works
Widespread insecticide resistance in Aedes aegypti L. from New Mexico, U.S.A.
Kandel, Y., Vulcan, J., Rodriguez, S. D., Moore, E., Chung, H.-N., Mitra, S., Cordova, J. J., Martinez, K. J. L., Moon, A. S., Kulkarni, A., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212693 · Cited by 62 · see citing works
Kasai, S., Itokawa, K., Uemura, N., Takaoka, A., Furutani, S., Maekawa, Y., Kobayashi, D., Imanishi-Kobayashi, N., Amoa‐Bosompem, M., Murota, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq7345 · Cited by 61 · see citing works
Filho, A. A. P., Pessoa, G. C. D., Yamaguchi, L. F., Stanton, M. A., Serravite, A. M., Pereira, R. H. M., Neves, W. S., & Kato, M. J. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.685864 · Cited by 60 · see citing works
Andreazza, F., de Oliveira, E. E., & Martins, G. F. (2021) · Insects · doi:10.3390/insects12100917 · Cited by 61 · see citing works
Self-citationChronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti
Chen, M., Du, Y., Nomura, Y., Zhorov, B. S., & Dong, K. (2020) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21686 · Cited by 59 · see citing works
Self-citationRahman, R. U., Souza, B. N. R. F., Uddin, I., Carrara, L., Brito, L. P., Costa, M. M., Mahmood, M. A., Khan, S., Lima, J. B. P., & Martins, A. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-83465-w · Cited by 59 · see citing works
Naggar, Y. A., Fahmy, N. M., Alkhaibari, A. M., Al-Akeel, R. K., Alharbi, H. M., Mohamed, A. A., Eleftherianos, I., El-Seedi, H. R., Giesy, J. P., & Alharbi, H. A. (2025) · Toxics · doi:10.3390/toxics13080681 · Cited by 65 · see citing works
Granada, Y., Mejía‐Jaramillo, A. M., Strode, C., & Triana‐Chávez, O. (2018) · Insects · doi:10.3390/insects9010023 · Cited by 57 · see citing works
Kushwah, R. B. S., Kaur, T., Dykes, C. L., Kumar, H. R., Kapoor, N., & Singh, O. P. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04201-3 · Cited by 57 · see citing works
Konan, L. Y., Oumbouke, W. A., Silué, U. G., Coulibaly, I. Z., Ziogba, J.-C. T., N’Guessan, R., Coulibaly, D., Bénié, J. B. V., & Lenhart, A. E. (2021) · Journal of Medical Entomology · doi:10.1093/jme/tjab045 · Cited by 53 · see citing works
Fan, Y., & Scott, J. G. (2020) · Pest Management Science · doi:10.1002/ps.5763 · Cited by 52 · see citing works
Kdr genotyping in Aedes aegypti from Brazil on a nation-wide scale from 2017 to 2018
Costa, M. M., Campos, K. B., Brito, L. P., Roux, E., Rodovalho, C. D. M., Bellinato, D. F., Lima, J. B. P., & Martins, A. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70029-7 · Cited by 51 · see citing works
Fernando, H. S. D., Hapugoda, M. D., Perera, R. M., Saavedra-Rodríguez, K., Black, W. C., & Silva, N. K. D. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-3113-0 · Cited by 49 · see citing works
Insecticide resistance status of Aedes aegypti in Bangladesh
Al‐Amin, H. M., Johora, F. T., Irish, S. R., Hossainey, M. R. H., Vizcaino, L., Paul, K. K., Khan, W. A., Haque, R., Alam, M. S., & Lenhart, A. E. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04503-6 · Cited by 47 · see citing works
Djiappi-Tchamen, B., Nana-Ndjangwo, M. S., Mavridis, K., Talipouo, A., Nchoutpouen, E., Makoudjou, I., Bamou, R., Mayi, M. P. A., Awono‐Ambene, P., Tchuinkam, T., et al. (2021) · Genes · doi:10.3390/genes12060828 · Cited by 48 · see citing works
Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity
Fernandes, K. M., Tomé, H. V. V., Miranda, F. R., Gonçalves, W. G., Pascini, T. V., Serrão, J. É., & Martins, G. F. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.01.068 · Cited by 45 · see citing works
Self-citationWilliams, J., Cowlishaw, R., Sanou, A., Ranson, H., & Grigoraki, L. (2021) · Pest Management Science · doi:10.1002/ps.6731 · Cited by 45 · see citing works
Tancredi, A., Papandrea, D., Marconcini, M., Carballar‐Lejarazú, R., Casas‐Martínez, M., Lo, E., Chen, X., Malacrida, A. R., & Bonizzoni, M. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008350 · Cited by 44 · see citing works
Uemura, N., Itokawa, K., Komagata, O., & Kasai, S. (2024) · Current Opinion in Insect Science · doi:10.1016/j.cois.2024.101178 · Cited by 43 · see citing works
Endersby‐Harshman, N. M., Schmidt, T. L., Chung, J., van Rooyen, A. R. J., Weeks, A. R., & Hoffmann, A. A. (2020) · Molecular Ecology · doi:10.1111/mec.15430 · Cited by 43 · see citing works
Solís-Santoyo, F., Rodríguez, A. D., Penilla-Navarro, R. P., Sánchez, D., Castillo, A., López-Solís, A. D., Vazquez-Lopez, E. D., Lozano‐Fuentes, S., Black, W. C., & Saavedra-Rodríguez, K. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009746 · Cited by 43 · see citing works
Toé, K. H., Zongo, S., Guelbeogo, M. W., Kamgang, B., Viana, M. S., Tapsoba, M., Sanou, A., Traoré, A., McCall, P. J., & Sagnon, N. (2022) · Medical and Veterinary Entomology · doi:10.1111/mve.12602 · Cited by 41 · see citing works
Conservation of the voltage‐sensitive sodium channel protein within the Insecta
Silva, J. J., & Scott, J. G. (2019) · Insect Molecular Biology · doi:10.1111/imb.12605 · Cited by 39 · see citing works
Rigby, L., Rašić, G., Peatey, C. L., Hugo, L. E., Beebe, N. W., & Devine, G. J. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04238-4 · Cited by 39 · see citing works
Fernando, H. S. D., Saavedra-Rodríguez, K., Perera, R. M., Black, W. C., & Silva, N. K. D. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04284-y · Cited by 42 · see citing works
Devine, G. J., Vazquez‐Prokopec, G. M., Bibiano-Marín, W., Pavía‐Ruz, N., Che‐Mendoza, A., Medina‐Barreiro, A., Villegas‐Chim, J., González‐Olvera, G., Dunbar, M. W., Ong, O. T. W., et al. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009036 · Cited by 39 · see citing works
Cattel, J., Faucon, F., Péron, B. L., Sherpa, S., Monchal, M., Grillet, L., Gaude, T., Laporte, F., Dusfour, I., Reynaud, S., et al. (2019) · Evolutionary Applications · doi:10.1111/eva.12867 · Cited by 38 · see citing works
Granada, Y., Mejía‐Jaramillo, A. M., Zuluaga, S., & Triana‐Chávez, O. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010001 · Cited by 37 · see citing works
Silva, I. M. A., Martins, G., Melo, C., Santana, A., Faro, R., Blank, A., Alves, P., Picanço, M., Cristaldo, P. F., Araújo, A. P., et al. (2018) · Pest Management Science · doi:10.1002/ps.4801 · Cited by 34 · see citing works
Self-citationKamgang, B., Wilson-Bahun, T. A., Yougang, A. P., Lenga, A., & Wondji, C. S. (2020) · Infectious Diseases of Poverty · doi:10.1186/s40249-020-0637-2 · Cited by 36 · see citing works
Permethrin Resistance in Aedes aegypti Affects Aspects of Vectorial Capacity
Chen, T.-Y., Smartt, C. T., & Shin, D. (2021) · Insects · doi:10.3390/insects12010071 · Cited by 37 · see citing works
Yougang, A. P., Kamgang, B., Wilson-Bahun, T. A., Tedjou, A. N., Nguiffo-Nguete, D., Njiokou, F., & Wondji, C. S. (2020) · Infectious Diseases of Poverty · doi:10.1186/s40249-020-00769-1 · Cited by 35 · see citing works
Borges, J. C. M., Haddi, K., de Oliveira, E. E., Andrade, B. S., Nascimento, V. L., Melo, T. S., Didonet, J., Carvalho, J. C. T., Cangussu, A. S. R., Soares, I. M., et al. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.12.022 · Cited by 34 · see citing works
Self-citationRahman, R. U., Cosme, L. V., Costa, M. M., Carrara, L., Lima, J. B. P., & Martins, A. J. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008492 · Cited by 34 · see citing works
Zuharah, W. F., & Sufian, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-84669-w · Cited by 34 · see citing works
Ortega, D. S., Bacca, T., Silva, A. P. N., Canal, N. A., & Haddi, K. (2021) · Journal of Stored Products Research · doi:10.1016/j.jspr.2021.101802 · Cited by 33 · see citing works
Self-citationSaavedra-Rodríguez, K., Campbell, C. L., Lozano‐Fuentes, S., Penilla-Navarro, R. P., López-Solís, A. D., Solís-Santoyo, F., Rodríguez, A. D., Perera, R. M., & Black, W. C. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009606 · Cited by 33 · see citing works
Lima, A. R., Silva, C. M., Caires, C. S. A., Prado, E. D., Rocha, L. R. P., Cabrini, I., de Arruda, E. J., Oliveira, S. L., & Caires, A. R. L. (2018) · Insects · doi:10.3390/insects9030109 · Cited by 32 · see citing works
Mukhtar, M. M., & Ibrahim, S. S. (2022) · Insects · doi:10.3390/insects13020187 · Cited by 32 · see citing works
Itokawa, K., Yatsu, K., Sekizuka, T., Maekawa, Y., Komagata, O., Sugiura, M., Sasaki, T., Tomita, T., Kuroda, M., Sawabe, K., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007818 · Cited by 31 · see citing works
Epelboin, Y., Wang, L., Gianetto, Q. G., Choumet, V., Gaborit, P., Issaly, J., Guidez, A., Douché, T., Chaze, T., Matondo, M., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0243992 · Cited by 30 · see citing works
Serrano, R. Y. M., Pareja–Loaiza, P., Gómez‐Camargo, D., Ponce‐García, G., & Flores, A. E. (2018) · Pest Management Science · doi:10.1002/ps.5287 · Cited by 29 · see citing works
de Araújo, A. P., Paiva, M. H. S., Cabral, A., Cavalcanti, A. E. H. D., Pessoa, L. F. F., Diniz, D. F. A., Helvécio, E., da Silva, É. V. G., da Silva, N. M., Anastácio, D. B., et al. (2019) · Journal of Insect Science · doi:10.1093/jisesa/iez054 · Cited by 29 · see citing works
Contreras‐Perera, Y., Ponce‐García, G., Villanueva‐Segura, O. K., López-Monroy, B., Rodriguez-Sanchez, I. P., Lenhart, A. E., Manrique-Saide, P. C., & Flores, A. E. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04093-3 · Cited by 29 · see citing works
Baltzegar, J., Vella, M. R., Gunning, C. E., Vásquez, G. M., Astete, H., Stell, F. M., Fisher, M., Scott, T. W., Lenhart, A. E., Lloyd, A. L., et al. (2021) · Evolutionary Applications · doi:10.1111/eva.13269 · Cited by 29 · see citing works
Hernandez, J. R., Longnecker, M. T., Fredregill, C., Debboun, M., & Pietrantonio, P. V. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009833 · Cited by 29 · see citing works
Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance
Love, R. R., Sikder, J. R., Vivero, R. J., Matute, D. R., & Schrider, D. R. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad072 · Cited by 29 · see citing works
Ecology of Aedes Mosquitoes, the Major Vectors of Arboviruses in Human Population
Kweka, E. J., Baraka, V., Mathias, L., Mwang’onde, B. J., Baraka, G. T., Lyaruu, L. J., & Mahande, A. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81439 · Cited by 29 · see citing works
Pyrethroid resistance mechanisms in the major malaria vector species complex
Ingham, V. A., Grigoraki, L., & Ranson, H. (2023) · Entomologia Generalis · doi:10.1127/entomologia/2023/1880 · Cited by 27 · see citing works
Loss of pyrethroid resistance in newly established laboratory colonies of Aedes aegypti
Vera-Maloof, F. Z., Saavedra-Rodríguez, K., Penilla-Navarro, R. P., Rodríguez, A. D., Dzul-Manzanilla, F., Manrique-Saide, P. C., & Black, W. C. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007753 · Cited by 27 · see citing works
Wuliandari, J. R., Hoffmann, A. A., Tantowijoyo, W., & Endersby‐Harshman, N. M. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04304-x · Cited by 27 · see citing works
Akhir, M. A. M., Wajidi, M. F. F., Lavoué, S., Azzam, G., Jaafar, I. S., Besar, N. A. U. A. B. A., & Ishak, I. H. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05192-z · Cited by 27 · see citing works
Mating behavior of the West Nile virus vector Culex pipiens – role of behavioral asymmetries
Benelli, G. (2017) · Acta Tropica · doi:10.1016/j.actatropica.2017.12.024 · Cited by 26 · see citing works
Yougang, A. P., Keumeni, C. R., Wilson-Bahun, T. A., Tedjou, A. N., Njiokou, F., Wondji, C. S., & Kamgang, B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278779 · Cited by 26 · see citing works
Hernandez, J. R., Liu, S., Fredregill, C., & Pietrantonio, P. V. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011033 · Cited by 26 · see citing works
Villanueva‐Segura, O. K., Ontiveros-Zapata, K., López-Monroy, B., Ponce‐García, G., Gutiérrez-Rodríguez, S. M., Dávila-Barboza, J. A., Mora-Jasso, E. D. J., & Flores, A. E. (2019) · Journal of Medical Entomology · doi:10.1093/jme/tjz148 · Cited by 26 · see citing works
Insecticide resistance status of Aedes aegypti in southern and northern Ghana
Abdulai, A., Owusu-Asenso, C. M., Akosah-Brempong, G., Mohammed, A. R., Sraku, I. K., Attah, S. K., Forson, A. O., Weetman, D., & Afrane, Y. A. (2023) · Parasites & Vectors · doi:10.1186/s13071-023-05752-x · Cited by 25 · see citing works
Exome‐wide association of deltamethrin resistance in Aedes aegypti from Mexico
Saavedra-Rodríguez, K., Campbell, C. L., Lenhart, A. E., Penilla-Navarro, R. P., Lozano‐Fuentes, S., & Black, W. C. (2019) · Insect Molecular Biology · doi:10.1111/imb.12575 · Cited by 25 · see citing works
Itokawa, K., Furutani, S., Takaoka, A., Maekawa, Y., Sawabe, K., Komagata, O., Tomita, T., Filho, J. L. D. L., Alves, L. C., & Kasai, S. (2021) · Pest Management Science · doi:10.1002/ps.6324 · Cited by 24 · see citing works
Silva, J. J., Kouam, C., & Scott, J. G. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009549 · Cited by 24 · see citing works
Hernandez, J. R., & Pietrantonio, P. V. (2025) · Parasites & Vectors · doi:10.1186/s13071-025-07010-8 · Cited by 26 · see citing works
Mack, L. K., Kelly, E. T., Lee, Y., Brisco, K. K., Shen, K. V., Zahid, A., van Schoor, T., Cornel, A. J., & Attardo, G. M. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04627-3 · Cited by 23 · see citing works
Enayati, A., Valadan, R., Bagherzadeh, M., Cheraghpour, M., Nikookar, S. H., Fazeli‐Dinan, M., Hosseini-Vasoukolaei, N., Sahraei-Rostami, F., Kordshouli, R. S., Raeisi, A., et al. (2024) · Parasites & Vectors · doi:10.1186/s13071-024-06123-w · Cited by 23 · see citing works
Campos, M., Ward, D., Morales, R. F., Gomes, A. R., Silva, K., Sepúlveda, N., Gómez, L. F., Clark, T. G., & Campino, S. G. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04356-z · Cited by 23 · see citing works
de Oliveira, A. C., Sá, I. S. C., Mesquita, R. D. S., Pereira, B. L., Pocrifka, L. A., de Souza, T. P., Amado, J. R. R., Azevedo, S. G., Sanches, E. A., Nunomura, S. M., et al. (2020) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-020-00092-8 · Cited by 22 · see citing works
Montgomery, M., Harwood, J. F., Yougang, A. P., Wilson-Bahun, T. A., Tedjou, A. N., Keumeni, C. R., Kilpatrick, A. M., Wondji, C. S., & Kamgang, B. (2022) · Infectious Diseases of Poverty · doi:10.1186/s40249-022-01013-8 · Cited by 22 · see citing works
Sombié, A., Ouédraogo, W. M., Oté, M., Saiki, E., Sakurai, T., Yameogo, F., Sanon, A., McCall, P. J., Kanuka, H., Weetman, D., et al. (2023) · Parasites & Vectors · doi:10.1186/s13071-023-05743-y · Cited by 22 · see citing works
High throughput sequencing reveals Drosophila suzukii responses to insecticides
Mishra, R., Chiu, J. C., Hua, G., Tawari, N. R., Adang, M. J., & Sial, A. A. (2017) · Insect Science · doi:10.1111/1744-7917.12498 · Cited by 22 · see citing works
Gutiérrez, Y., Ramos, G. S., Tomé, H. V. V., de Oliveira, E. E., & Salaro, A. L. (2017) · Ecotoxicology · doi:10.1007/s10646-017-1840-1 · Cited by 22 · see citing works
Self-citationValbon, W. R., Andreazza, F., de Oliveira, E. E., Liu, F., Bo, F., Hall, M. J., Klimavicz, J. S., Coats, J. R., & Dong, K. (2021) · Pest Management Science · doi:10.1002/ps.6682 · Cited by 20 · see citing works
Self-citationde Oliveira, A. C., Simões, R. D. C., Tavares, C. P. S., Lima, C. A. P., Sá, I. S. C., da Silva, F. M. A., Figueira, É. A. G., Nunomura, S. M., Nunomura, R. D. C. S., & Roque, R. A. (2022) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2022.105265 · Cited by 21 · see citing works
Zardkoohi, A., Castañeda, D., Lol, J. C., Castillo, C., López, F., Rodríguez, R. M., & Padilla, N. (2019) · Journal of Medical Entomology · doi:10.1093/jme/tjz241 · Cited by 21 · see citing works
Transcriptomic and proteomic analysis of pyrethroid resistance in the CKR strain of Aedes aegypti
Sun, H., Mertz, R. W., Smith, L. B., & Scott, J. G. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009871 · Cited by 20 · see citing works
Amlalo, G., Akorli, J., Akyea-Bobi, N. E., Akporh, S., Acquah-Baidoo, D., Opoku, M., Frempong, K. K., Pi-Bansa, S., Boakye, H. A., Joannides, J., et al. (2022) · Journal of Medical Entomology · doi:10.1093/jme/tjac120 · Cited by 20 · see citing works
Acford-Palmer, H., Campos, M., Bandibabone, J., N’Do, S., Chimanuka, B., Zawadi, B., Walker, T., Phelan, J. E., Messenger, L. A., Clark, T. G., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-44457-0 · Cited by 19 · see citing works
Valbon, W. R., Cruz, F. M., Ramos, G. S., Tomé, H. V. V., & de Oliveira, E. E. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.10.061 · Cited by 20 · see citing works
Self-citationValbon, W. R., Haddi, K., Souza, R. A., Carvalho, G. A., Guedes, R. N. C., Martins, G. F., & de Oliveira, E. E. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.02.008 · Cited by 20 · see citing works
Self-citationMarcombe, S., Shimell, K., Savage, R., Howlett, E., Luangamath, P., Nilaxay, S., Vungkyly, V., Baby, A., King, M., Clarke, J., et al. (2022) · Medical and Veterinary Entomology · doi:10.1111/mve.12580 · Cited by 19 · see citing works
Soleño, J., Parra-Morales, L. B., Cichón, L., Garrido, S. A., Guiñazú, N. L., & Montagna, C. M. (2019) · Bulletin of Entomological Research · doi:10.1017/s0007485319000439 · Cited by 19 · see citing works
Hayd, R. L. N., Carrara, L., Lima, J. D. M., de Almeida, N. C. V., Lima, J. B. P., & Martins, A. J. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04127-w · Cited by 19 · see citing works
Valbon, W. R., Hatano, E., de Oliveira, N. R. X., Ataíde, Á. D., Corrêa, M. J. M., Gomes, S. F., Martins, G. F., Haddi, K., Alvarenga, E. S., & de Oliveira, E. E. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117130 · Cited by 19 · see citing works
Self-citationOmics Approaches in Understanding Insecticide Resistance in Mosquito Vectors
Bharadwaj, N., Sharma, R., Subramanian, M., Ragini, G., Shriram, A. N., & Rahi, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051854 · Cited by 18 · see citing works
Nachaiwieng, W., Yanola, J., Chamnanya, S., Lumjuan, N., & Somboon, P. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104911 · Cited by 18 · see citing works
Maiga, A.-A., Sombié, A., Zanré, N., Yameogo, F., Iro, S. M., Testa, J., Sanon, A., Koita, O., Kanuka, H., McCall, P. J., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304550 · Cited by 18 · see citing works
Valbon, W. R., Haddi, K., Gutiérrez, Y., Cruz, F. M., Azevedo, K. E. X., Campos, J. S. P., Salaro, A. L., & de Oliveira, E. E. (2019) · Neotropical Entomology · doi:10.1007/s13744-019-00710-8 · Cited by 18 · see citing works
Self-citation
- Authors
- Haddi, K., Tomé, H. V. V., Du, Y., Valbon, W. R., Nomura, Y., Martins, G. F., Dong, K., & Oliveira, E. E.
- Affiliations
- Universidade Federal de Viçosa (BR)
- Michigan State University (US)
- Corresponding author
- Haddi, Khalid
- Venue
- Scientific Reports
- Published
- 2017-04-19
- Volume
- 7
- Issue
- 1
- Pages
- 46549-46549
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5396194
- OpenAlex
- W2606667865
- Cited by
- 208
- References
- 41
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 21 · 2023: 20 · 2022: 21 · 2021: 37 · 2020: 31 · 2019: 20 · 2018: 10 · 2017: 6
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Fundação Arthur Bernardes
- National Institutes of Health
- Ciência sem Fronteiras
- National Institute of General Medical Sciences (R01GM057440)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Social Sciences › Sociology and Political Science › Dengue and Mosquito Control Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Keywords
- Aedes aegypti, pyrethroid resistance, F1534C mutation, voltage-gated sodium channels, insecticide resistance, mosquito control, resistance management, dengue vector, Brazil
- MeSH terms
- Mosquito Vectors, Aedes, Animals, Drug Resistance, Mosquito Control, Pyrethrins, Sodium Channels, Insect Proteins, Amino Acid Substitution, Mutation, Missense
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review