The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models
Open accessAbstract
Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer’s disease (AD). Neurodegenerative effects of particulate air pollutants were examined in a US-wide cohort of older women from the Women’s Health Initiative Memory Study (WHIMS) and in experimental mouse models. Residing in places with fine PM exceeding EPA standards increased the risks for global cognitive decline and all-cause dementia respectively by 81 and 92%, with stronger adverse effects in APOE ɛ4/4 carriers. Female EFAD transgenic mice (5xFAD+/−/human APOE ɛ 3 or ɛ 4+/+) with 225 h exposure to urban nanosized PM (nPM) over 15 weeks showed increased cerebral β-amyloid by thioflavin S for fibrillary amyloid and by immunocytochemistry for Aβ deposits, both exacerbated by APOE ɛ4. Moreover, nPM exposure increased Aβ oligomers, caused selective atrophy of hippocampal CA1 neurites, and decreased the glutamate GluR1 subunit. Wildtype C57BL/6 female mice also showed nPM-induced CA1 atrophy and GluR1 decrease. In vitro nPM exposure of neuroblastoma cells (N2a-APP/swe) increased the pro-amyloidogenic processing of the amyloid precursor protein (APP). We suggest that airborne PM exposure promotes pathological brain aging in older women, with potentially a greater impact in ɛ4 carriers. The underlying mechanisms may involve increased cerebral Aβ production and selective changes in hippocampal CA1 neurons and glutamate receptor subunits.
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Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study
Chen, H., Kwong, J. C., Copes, R., Hystad, P., van Donkelaar, A., Tu, K., Brook, J. R., Goldberg, M. S., Martin, R. V., Murray, B. J., et al. (2017) · Environment International · doi:10.1016/j.envint.2017.08.020 · Cited by 394
Metadata
- Authors
- Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., Gatz, M., Chui, H. C., Shumaker, S. A., Resnick, S. M., Espeland, M. A., Finch, C. E., & Chen, J. C.
- Venue
- Translational Psychiatry
- Published
- 2017-01-31
- Volume
- 7
- Issue
- 1
- Pages
- e1022-e1022
- ISSN
- 2158-3188 (ISSN-L)
- OpenAlex
- W2584621797
- Cited by
- 432
- References
- 59
- FWCI
- 26.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., Gatz, M., Chui, H. C., Shumaker, S. A., Resnick, S. M., Espeland, M. A., Finch, C. E., & Chen, J. C. (2017). Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Translational Psychiatry. https://doi.org/10.1038/tp.2016.280
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
