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The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention

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Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, Lan, Yu, Jin-Tai·2021·The Journal of Prevention of Alzheimer's Disease
DOI 10.14283/jpad.2021.15PMC PMC12280729
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Abstract

Mild Alzheimer's disease is the leading cause of dementia, accounting for 50-70% of cases. Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life activities and social functioning. As life expectancy increases and demographic ageing occurs, the global prevalence of Alzheimer's disease is expected to continue to rise especially in developing countries, leading to a costly burden of disease. Alzheimer's disease is a complex and multifactorial disorder that is determined by the interaction of genetic susceptibility and environmental factors across the life course. Epidemiological studies have identified potential modifiable risk and protective factors for Alzheimer's disease prevention. Moreover, Alzheimer's disease is considered to start decades earlier before clinical symptoms occur, thus interventions targeting several risk factors in non-demented elderly people even middle-aged population might prevent or delay Alzheimer's disease onset. Here, we provide an overview of current epidemiological advances related to Alzheimer's disease modifiable risk factors, highlighting the concept of early prevention.

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Cited by

Sorted by citations

Authors
Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T.
Affiliations
  • Qingdao University (CN)
  • Shanghai Medical College of Fudan University (CN)
Corresponding author
  • Tan, Lan
  • Yu, Jin-Tai
ORCID
Venue
The Journal of Prevention of Alzheimer's Disease
Publisher
Elsevier BV
Published
2021-07
Volume
8
Issue
3
Pages
313-321
ISSN
2274-5807 (ISSN-L)
DOI
10.14283/jpad.2021.15
PMC
PMC12280729
OpenAlex
W3151714526
Cited by
789
References
16
Citations by year
2026: 161 · 2025: 223 · 2024: 204 · 2023: 134 · 2022: 58 · 2021: 9
FWCI
18.05
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Prevention of Alzheimer s Disease (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Fudan University (2018SHZDZX01)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
Alzheimer's disease, modifiable risk factors, dementia prevention, early prevention, neurodegeneration, genetic susceptibility, environmental factors, life course, disease burden, population aging, protective factors
MeSH terms
Alzheimer Disease, Cardiovascular Diseases, Humans, Life Style, Risk Factors, Exercise, Prevalence, Protective Factors

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