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An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities
Abstract
This paper presents the development and characterization of an integrated microfluidic biochemical detection system for fast and low-volume immunoassays using magnetic beads, which are used as both immobilization surfaces and bio-molecule carriers. Microfluidic components have been developed and integrated to construct a microfluidic biochemical detection system. Magnetic bead-based immunoassay, as a typical example of biochemical detection and analysis, has been successfully performed on the integrated microfluidic biochemical analysis system that includes a surface-mounted biofilter and electrochemical sensor on a glass microfluidic motherboard. Total time required for an immunoassay was less than 20 min including sample incubation time, and sample volume wasted was less than 50 microl during five repeated assays. Fast and low-volume biochemical analysis has been successfully achieved with the developed biofilter and immunosensor, which is integrated to the microfluidic system. Such a magnetic bead-based biochemical detection system, described in this paper, can be applied to protein analysis systems.
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Citations
Cited by
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
Chikkaveeraiah, B. V., Bhirde, A. A., Morgan, N. Y., Eden, H. S., & Chen, X. (2012) · ACS Nano · doi:10.1021/nn3023969 · Cited by 719
BioMEMS: state-of-the-art in detection, opportunities and prospects
Bashir, R. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.03.002 · Cited by 462
Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies
Ahadian, S., Civitarese, R., Bannerman, D., Mohammadi, M. H., Lu, R., Wang, E., Davenport‐Huyer, L., Lai, B., Zhang, B., Zhao, Y., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700506 · Cited by 315
Microfluidic systems in proteomics
Lion, N., Rohner, T. C., Dayon, L., Arnaud, I. L., Damoc, E., Youhnovski, N., Wu, Z., Roussel, C., Josserand, J., Jensen, H., et al. (2003) · ELECTROPHORESIS · doi:10.1002/elps.200305629 · Cited by 262
Metadata
- Authors
- Choi, J.-W., Oh, K. W., Thomas, J. H., Heineman, W. R., Halsall, H. B., Nevin, J. H., Helmicki, A. J., Henderson, H. T., & Ahn, C. H.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2002
- Volume
- 2
- Issue
- 1
- Pages
- 27
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2013992558
- Cited by
- 364
- References
- 0
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Choi, J.-W., Oh, K. W., Thomas, J. H., Heineman, W. R., Halsall, H. B., Nevin, J. H., Helmicki, A. J., Henderson, H. T., & Ahn, C. H. (2002). An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities. Lab on a Chip. https://doi.org/10.1039/b107540n
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