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A fluorescent PEBBLE nanosensor for intracellular free zinc
Abstract
The development and characterisation of a fluorescent optical PEBBLE (Probe Encapsulated By Biologically Localised Embedding) nanosensor for the detection of zinc is detailed. A ratiometric sensor has been fabricated that incorporates two fluorescent dyes; one is sensitive to zinc and the other acts as a reference. The sensing components are entrapped within a polymer matrix by a microemulsion polymerisation process that produces spherical sensors that are in the size region of 20 to 200 nm. Cellular measurements are made possible by the small sensor size and the biocompatibility of the matrix. The effects of reversibility, photobleaching and leaching have been examined, as well as the selectivity towards zinc over other cellular ions such as Na+, Ca2+, K+, and Mg2+. The dynamic range of these sensors was found to be 4 to 50 microM Zn2+ with a linear range from 15 to 40 microM. The response time for the PEBBLE is less than 4 s and the sensor is reversible. In addition, the nanosensors are photostable and leaching from the matrix, determined using a novel method, is minimal. These sensors are capable of real-time inter- and intra-cellular imaging and are insensitive to interference from proteins.
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Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Nanotech approaches to drug delivery and imaging
Sahoo, S. K., & Labhasetwar, V. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02903-9 · Cited by 1,203
Jiang, P., & Guo, Z. (2004) · Coordination Chemistry Reviews · doi:10.1016/j.cct.2003.10.013 · Cited by 989
Implications of Nanobiosensors in Agriculture
Rai, V., Acharya, S., & Dey, N. (2012) · Journal of Biomaterials and Nanobiotechnology · doi:10.4236/jbnb.2012.322039 · Cited by 332
Metadata
- Authors
- Sumner, J. P., Aylott, J. W., Monson, E., & Kopelman, R.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2001-12-04
- Volume
- 127
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2022130063
- Cited by
- 160
- References
- 0
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sumner, J. P., Aylott, J. W., Monson, E., & Kopelman, R. (2002). A fluorescent PEBBLE nanosensor for intracellular free zinc. The Analyst. https://doi.org/10.1039/b108568a
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