The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
HIV-1 protease: mechanism and drug discovery
Abstract
A graphical abstract is available for this content
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy
Coffin, J. M. (1995) · Science · doi:10.1126/science.7824947 · Cited by 1,981
Mechanisms of Viral Membrane Fusion and Its Inhibition
Eckert, D. M., & Kim, P. S. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.777 · Cited by 1,282
Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease
Wlodawer, A., Miller, M., Jaskólski, M., Sathyanarayana, B. K., Baldwin, E., Weber, I. T., Selk, L. M., Clawson, L., Schneider, J., & Kent, S. B. H. (1989) · Science · doi:10.1126/science.2548279 · Cited by 1,168
Rational Design of Peptide-Based HIV Proteinase Inhibitors
Roberts, N. A., Martin, J. A., Kinchington, D., Broadhurst, A. V., Craig, J. C., Duncan, I. B., Galpin, S. A., Handa, B. K., Kay, J., Kröhn, A., et al. (1990) · Science · doi:10.1126/science.2183354 · Cited by 929
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
Babine, R. E., & Bender, S. L. (1997) · Chemical Reviews · doi:10.1021/cr960370z · Cited by 892
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
Lam, P. Y. S., Jadhav, P. K., Eyermann, C. J., Hodge, C. N., Ru, Y., Bacheler, L. T., Meek, J. L., Otto, M. J., Rayner, M. M., Wong, Y. N., et al. (1994) · Science · doi:10.1126/science.8278812 · Cited by 834
STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE
Wlodawer, A., & Erickson, J. W. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002551 · Cited by 833
Miller, M., Schneider, J., Sathyanarayana, B. K., Toth, M. V., Marshall, G. R., Clawson, L., Selk, L., Kent, S. B. H., & Wlodawer, A. (1989) · Science · doi:10.1126/science.2686029 · Cited by 684
ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
Sham, H. L., Kempf, D. J., Molla, A., Marsh, K. C., Kumar, G. N., Chen, C.-M., Kati, W., Stewart, K., Lal, R., Hsu, A., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.12.3218 · Cited by 471
Lapatto, R., Blundell, T., Hemmings, A., Overington, J., Wilderspin, A., Wood, S., Merson, J. R., Whittle, P. J., Danley, D. E., Geoghegan, K. F., et al. (1989) · Nature · doi:10.1038/342299a0 · Cited by 456
Cited by
Modeling water molecules in protein-ligand docking using GOLD.
Verdonk, M. L., Chessari, G., Cole, J. C., Hartshorn, M. J., Murray, C. W., Nissink, J. W. M., Taylor, R. D., & Taylor, R. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050543p · Cited by 393
Synthesis of proteins by automated flow chemistry
Hartrampf, N., Saebi, A., Poskus, M., Gates, Z. P., Callahan, A. J., Cowfer, A. E., Hanna, S., Antilla, S., Schissel, C. K., Quartararo, A. J., et al. (2020) · Science · doi:10.1126/science.abb2491 · Cited by 367
BERTology Meets Biology: Interpreting Attention in Protein Language Models
Vig, J., Madani, A., Varshney, L. R., Xiong, C., Socher, R., & Rajani, N. F. (2020) · doi:10.1101/2020.06.26.174417 · Cited by 338
A Force Field with Discrete Displaceable Waters and Desolvation Entropy for Hydrated Ligand Docking
Forli, S., & Olson, A. J. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2005145 · Cited by 290
Bacterial proteases, untapped antimicrobial drug targets
Culp, E., & Wright, G. D. (2017) · The Journal of Antibiotics · doi:10.1038/ja.2016.138 · Cited by 244
Metadata
- Authors
- Brik, A., & Wong, C.-H.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2002-11-26
- Volume
- 1
- Issue
- 1
- Pages
- 5-14
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W2104270610
- Cited by
- 455
- References
- 29
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: HIV-1 protease: mechanism and drug discovery. https://app.cochat.ai/papers/10.1039/b208248a
- The paper
- Brik, A., & Wong, C.-H. (2003). HIV-1 protease: mechanism and drug discovery. Organic & Biomolecular Chemistry. https://doi.org/10.1039/b208248a
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
