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Radiohalogens for imaging and therapy
Abstract
Radiohalogens play a very important role in radiopharmaceuticals used for medical imaging (now referred to as molecular imaging) and therapy applications. Development of new radiopharmaceuticals that have radiohalogens incorporated requires an understanding of parameters that are unique to chemistry involving these radionuclides. Those parameters include requirement for production and purification of the halogen radionuclides, as well as development of reaction conditions for use with high specific activity short-lived radionuclides. In this tutorial review, several radiohalogens, their radiolabeling chemistry and their application to medical imaging and therapy are discussed.
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Almutairi, A., Rossin, R., Shokeen, M., Hagooly, A., Ananth, A., Capoccia, B., Guillaudeu, S., Abendschein, D., Anderson, C. J., Welch, M. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811757106 · Cited by 235
Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity
Yu, Y., Liu, A., Dhawan, G., Mei, H., Zhang, W., Izawa, K., Soloshonok, V. A., & Han, J. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.05.042 · Cited by 182
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Li, X., Li, X., Zhang, X.-N., Li, X.-D., Chang, J., Zhang, X.-N., Li, X.-D., & Chang, J. (2016) · Cancer Biology & Medicine · doi:10.20892/j.issn.2095-3941.2016.0055 · Cited by 126
Warnier, C., Lemaire, C., Becker, G., Zaragoza, G., Giacomelli, F., Aerts, J., Otabashi, M., Bahri, M. A., Mercier, J., Plenevaux, A., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00905 · Cited by 58
Metadata
- Authors
- Adam, M. J., & Wilbur, D. S.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2005
- Volume
- 34
- Issue
- 2
- Pages
- 153
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2328039313
- Cited by
- 260
- References
- 0
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
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