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Ion mobility spectrometry: a review. Part 1. Structural analysis by mobility measurement
Abstract
Ion mobility spectrometry (IMS) is an electrophoretic technique that allows ionised analyte molecules to be separated on the basis of their mobilities in the gas phase. The technique has found widespread application as a detector, most noticeably for chemical warfare agents on the battlefield and for explosives and narcotics at ports and airports. The application of IMS to structural studies of small molecules has also been recognised since the advent of the technique in the 1970s. The coupling of IMS with electrospray (ESI) and MALDI ion sources has opened up exciting possibilities for the study of the conformations and structures of a wide range of biomolecules in the gas-phase, including proteins, peptides and oligonucletoides. This tutorial review discusses the principles, instrumentation and applications of IMS for the elucidation of molecular structural characteristics.
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Cited by
Electronic Nose: Current Status and Future Trends
Röck, F., Barsan, N., & Weimar, U. (2008) · Chemical Reviews · doi:10.1021/cr068121q · Cited by 1,437
Ion mobility–mass spectrometry
Kanu, A. B., Dwivedi, P., Tam, M., Matz, L., & Hill, H. H. (2008) · Journal of Mass Spectrometry · doi:10.1002/jms.1383 · Cited by 1,154
Lanucara, F., Holman, S. W., Gray, C. J., & Eyers, C. E. (2014) · Nature Chemistry · doi:10.1038/nchem.1889 · Cited by 901
Ion mobility mass spectrometry of proteins and proteinassemblies
Uetrecht, C., Rose, R. J., van Duijn, E., Lorenzen, K., & Heck, A. J. R. (2010) · Chem. Soc. Rev. · doi:10.1039/b914002f · Cited by 462
Lapthorn, C., Pullen, F., & Chowdhry, B. Z. (2013) · Mass Spectrometry Reviews · doi:10.1002/mas.21349 · Cited by 398
Metadata
- Authors
- Creaser, C. S., Griffiths, J. R., Bramwell, C. J., Noreen, S., Hill, C. A., & Thomas, C. L. P.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2004
- Volume
- 129
- Issue
- 11
- Pages
- 984
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2076067099
- Cited by
- 235
- References
- 0
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Creaser, C. S., Griffiths, J. R., Bramwell, C. J., Noreen, S., Hill, C. A., & Thomas, C. L. P. (2004). Ion mobility spectrometry: a review. Part 1. Structural analysis by mobility measurement. The Analyst. https://doi.org/10.1039/b404531a
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