The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Measuring the metabolome: current analytical technologies
Abstract
The post-genomics era has brought with it ever increasing demands to observe and characterise variation within biological systems. This variation has been studied at the genomic (gene function), proteomic (protein regulation) and the metabolomic (small molecular weight metabolite) levels. Whilst genomics and proteomics are generally studied using microarrays (genomics) and 2D-gels or mass spectrometry (proteomics), the technique of choice is less obvious in the area of metabolomics. Much work has been published employing mass spectrometry, NMR spectroscopy and vibrational spectroscopic techniques, amongst others, for the study of variations within the metabolome in many animal, plant and microbial systems. This review discusses the advantages and disadvantages of each technique, putting the current status of the field of metabolomics in context, and providing examples of applications for each technique employed.
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Cites
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Cited by
The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.335 · Cited by 3,294
Self-citationCurrent approaches and challenges for the metabolite profiling of complex natural extracts
Wolfender, J.-L., Marti, G., Thomas, A., & Bertrand, S. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.10.091 · Cited by 635
Organization of GC/MS and LC/MS metabolomics data into chemical libraries
DeHaven, C. D., Evans, A. M., Dai, H., & Lawton, K. A. (2010) · Journal of Cheminformatics · doi:10.1186/1758-2946-2-9 · Cited by 601
Bonneau, R., Reiss, D. J., Shannon, P., Facciotti, M., Hood, L., Baliga, N. S., & Thorsson, V. (2006) · Genome Biology · doi:10.1186/gb-2006-7-5-r36 · Cited by 510
National Algal Biofuels Technology Roadmap
USDOE Office of Energy Efficiency and Renewable Energy (EERE), O. O. S. T. B. T. O. (., Ferrell, J., US Department of Energy (USDOE), W., & Sarisky-Reed, V. (2010) · doi:10.2172/1218560 · Cited by 470
Metadata
- Authors
- Dunn, W. B., Bailey, N. J. C., & Johnson, H. E.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2005
- Volume
- 130
- Issue
- 5
- Pages
- 606
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2137585293
- Cited by
- 924
- References
- 5
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
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