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High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets
Abstract
A high-performance flow-focusing geometry for spontaneous generation of monodispersed droplets is demonstrated. In this geometry, a two-phase flow is forced through a circular orifice integrated inside a silicon-based microchannel. The orifice with its cusp-like edge exerts a ring of maximized stress around the flow and ensures controlled breakup of droplets for a wide range of flow rates, forming highly periodic and reproducible dispersions. The droplet generation can be remarkably rapid, exceeding 10(4) s(-1) for water-in-oil droplets and reaching 10(3) s(-1) for oil-in-water droplets, being largely controlled by flow rate of the continuous phase. The droplet diameter and generation frequency are compared against a quasi-equilibrium model based on the critical Capillary number. The droplets are obtained despite the low Capillary number, below the critical value identified by the ratio of viscosities between the two phases and simple shear-flow.
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Citations
Cited by
Teh, S.-Y., Lin, R., Hung, L.-H., & Lee, A. P. (2008) · Lab on a Chip · doi:10.1039/b715524g · Cited by 2,690
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Zhu, P., & Wang, L. (2017) · Lab on a Chip · doi:10.1039/c6lc01018k · Cited by 1,238
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Surfactants in droplet-based microfluidics
Baret, J.-C. (2012) · Lab Chip · doi:10.1039/c1lc20582j · Cited by 649
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594
Metadata
- Authors
- Yobas, L., Martens, S., Ong, W.-L., & Ranganathan, N.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 6
- Issue
- 8
- Pages
- 1073
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2062573677
- Cited by
- 293
- References
- 0
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yobas, L., Martens, S., Ong, W.-L., & Ranganathan, N. (2006). High-performance flow-focusing geometry for spontaneous generation of monodispersed droplets. Lab on a Chip. https://doi.org/10.1039/b602240e
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