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Cited by 391

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The type I fatty acid and polyketide synthases: a tale of two megasynthases

Open access
Smith, Stuart, Tsai, Shiou-Chuan·2007·Natural Product Reports
DOI 10.1039/b603600g
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Abstract

This review chronicles the synergistic growth of the fields of fatty acid and polyketide synthesis over the last century. In both animal fatty acid synthases and modular polyketide synthases, similar catalytic elements are covalently linked in the same order in megasynthases. Whereas in fatty acid synthases the basic elements of the design remain immutable, guaranteeing the faithful production of saturated fatty acids, in the modular polyketide synthases, the potential of the basic design has been exploited to the full for the elaboration of a wide range of secondary metabolites of extraordinary structural diversity.

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Metadata

Authors
Smith, S., & Tsai, S.-C.
Venue
Natural Product Reports
Publisher
Royal Society of Chemistry (RSC)
Published
2007
Volume
24
Issue
5
Pages
1041
ISSN
  • 0265-0568 (ISSN-L)
  • 1460-4752
DOI
10.1039/b603600g
OpenAlex
W2004481736
Cited by
391
References
0
FWCI
13.32
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The type I fatty acid and polyketide synthases: a tale of two megasynthases. https://app.cochat.ai/papers/10.1039/b603600g
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Smith, S., & Tsai, S.-C. (2007). The type I fatty acid and polyketide synthases: a tale of two megasynthases. Natural Product Reports. https://doi.org/10.1039/b603600g

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.