The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Flavoenzymes: Versatile catalysts in biosynthetic pathways
Open accessAbstract
Riboflavin-based coenzymes, tightly bound to enzymes catalyzing substrate oxidations and reductions, enable an enormous range of chemical transformations in biosynthetic pathways. Flavoenzymes catalyze substrate oxidations involving amine and alcohol oxidations and desaturations to olefins, the latter setting up Diels-Alder cyclizations in lovastatin and solanapyrone biosyntheses. Both C(4a) and N(5) of the flavin coenzymes are sites for covalent adduct formation. For example, the reactivity of dihydroflavins with molecular oxygen leads to flavin-4a-OOH adducts which then carry out a diverse range of oxygen transfers, including Baeyer-Villiger type ring expansions, olefin epoxidations, halogenations via transient HOCl generation, and an oxidative Favorskii rerrangement during enterocin assembly.
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Fischbach, M. A., & Walsh, C. T. (2006) · Chemical Reviews · doi:10.1021/cr0503097 · Cited by 1,464
Self-citationThe Biosynthetic Logic of Polyketide Diversity
Hertweck, C. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200806121 · Cited by 1,346
Activation of molecular oxygen by flavins and flavoproteins.
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Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
Self-citationCyclopiazonic Acid is a Specific Inhibitor of the Ca2+-ATPase of Sarcoplasmic Reticulum
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Bleomycins: towards better therapeutics
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Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
Hertweck, C., Luzhetskyy, A., Rebets, Y., & Bechthold, A. (2007) · Nat. Prod. Rep. · doi:10.1039/b507395m · Cited by 591
Mechanisms of flavoprotein‐catalyzed reactions
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Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate
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Self-citationBiological formation of pyrroles: Nature's logic and enzymatic machinery
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Flavin dependent monooxygenases
Huijbers, M. M. E., Montersino, S., Westphal, A. H., Tischler, D., & van Berkel, W. J. H. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.12.005 · Cited by 527
Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds
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Metadata
- Authors
- Walsh, C. T., & Wencewicz, T. A.
- Venue
- Nat. Prod. Rep.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 30
- Issue
- 1
- Pages
- 175-200
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2130775475
- Cited by
- 373
- References
- 98
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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