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Chemical double-mutant cycles: dissecting non-covalent interactions
Abstract
Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.
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Cited by
Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
Salonen, L. M., Ellermann, M., & Diederich, F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007560 · Cited by 1,539
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
Beno, B. R., Yeung, K.-S., Bartberger, M. D., Pennington, L. D., & Meanwell, N. A. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501853m · Cited by 772
Local Nature of Substituent Effects in Stacking Interactions
Wheeler, S. E. (2011) · Journal of the American Chemical Society · doi:10.1021/ja202932e · Cited by 466
Solís, D., Bovin, N. V., Davis, A. P., Jiménez-Barbero, J., Romero, A., Roy, R., Smetana, K., & Gabius, H.-J. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.03.016 · Cited by 222
Adib, M., Islam, R., Ahsan, M., Rahman, A., Hossain, M., Rahman, M. M., Alshehri, S. M., Kazi, M., & Mazid, M. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.03.063 · Cited by 19
Metadata
- Authors
- Cockroft, S. L., & Hunter, C. A.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 36
- Issue
- 2
- Pages
- 172-188
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2145602919
- Cited by
- 281
- References
- 0
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
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