The DOI matches its Crossref record.
A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis
Abstract
Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.
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Citations
Cited by
The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.335 · Cited by 3,294
Self-citationBridgewater BR, E. A. (2014) · Journal of Postgenomics Drug & Biomarker Development · doi:10.4172/2153-0769.1000132 · Cited by 389
LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics
Theodoridis, G., Gika, H. G., & Wilson, I. D. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.01.008 · Cited by 371
Self-citationQuantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives
Koek, M. M., Jellema, R. H., van der Greef, J., Tas, A. C., & Hankemeier, T. (2011) · Metabolomics · doi:10.1007/s11306-010-0254-3 · Cited by 353
Method validation strategies involved in non-targeted metabolomics
Naz, S., Vallejo, M., García, A., & Barbas, C. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.04.071 · Cited by 332
Metadata
- Authors
- Sangster, T., Major, H., Plumb, R., Wilson, A. J., & Wilson, I. D.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 131
- Issue
- 10
- Pages
- 1075
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2066896487
- Cited by
- 564
- References
- 0
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sangster, T., Major, H., Plumb, R., Wilson, A. J., & Wilson, I. D. (2006). A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. The Analyst. https://doi.org/10.1039/b604498k
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