The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
Abstract
Since the discovery of Cu(I)-catalysed click chemistry, the field of peptidomimetics has expanded to include 1,4-connected 1,2,3-triazoles as useful peptide bond isosteres. Here, we report the synthesis of triazole-containing analogues of the naturally occurring tyrosinase inhibitor cyclo-[Pro-Val-Pro-Tyr] and show that the analogues retain enzyme inhibitory activity, demonstrating the effectiveness of a 1,4-connected 1,2,3-triazole as a trans peptide bond isostere.
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Citations
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Cited by
Cu-Catalyzed Azide−Alkyne Cycloaddition
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Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
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Metadata
- Authors
- Bock, V. D., Speijer, D., Hiemstra, H., & van Maarseveen, J. H.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 5
- Issue
- 6
- Pages
- 971
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W2133857972
- Cited by
- 287
- References
- 32
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- closed
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