The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enzymatic synthesis of cyclic triterpenes
Abstract
This review covers recent advances in the chemistry and enzymology of squalene cyclase and oxidosqualene cyclase. The enzymatic cyclizations of squalene and oxidosqualene are the most remarkable steps in the biosynthesis of sterols and triterpenes. The polyenes are converted to various polycyclic triterpenes by different enzyme systems employing only small modification of the active-site. Recent crystallographic and structure-based mutagenesis studies as well as utilization of chemically synthesized active-site probes have begun to reveal intimate structural details of the enzyme-templated cyclization reactions. 126 References are cited.
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Cites
2,3-Oxidosqualene, an Intermediate in the Biological Synthesis of Sterols from Squalene1
Corey, E. J., Russey, W. E., & de Montellano, P. R. O. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00972a056 · Cited by 225
Cited by
Dougherty, D. A. (2013) · Accounts of Chemical Research · doi:10.1021/ar300265y · Cited by 1,155
Jan, R., Asaf, S., Numan, M., Lubna, & Kim, K.-M. (2021) · Agronomy · doi:10.3390/agronomy11050968 · Cited by 832
Triterpene Biosynthesis in Plants
Thimmappa, R., Geisler, K., Louveau, T., O'Maille, P., & Osbourn, A. (2014) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120229 · Cited by 803
Molecular activities, biosynthesis and evolution of triterpenoid saponins
Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Pollier, J., & Goossens, A. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2011.12.022 · Cited by 499
Metadata
- Authors
- Abe, I.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 24
- Issue
- 6
- Pages
- 1311
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2070456262
- Cited by
- 228
- References
- 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
