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Quadruplex DNA: sequence, topology and structure

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Burge, Sarah, Parkinson, Gary N., Hazel, Pascale, Todd, Alan K., Neidle, Stephen·2006·Nucleic Acids Research
DOI 10.1093/nar/gkl655
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Abstract

G-quadruplexes are higher-order DNA and RNA structures formed from G-rich sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential quadruplex sequences have been identified in G-rich eukaryotic telomeres, and more recently in non-telomeric genomic DNA, e.g. in nuclease-hypersensitive promoter regions. The natural role and biological validation of these structures is starting to be explored, and there is particular interest in them as targets for therapeutic intervention. This survey focuses on the folding and structural features on quadruplexes formed from telomeric and non-telomeric DNA sequences, and examines fundamental aspects of topology and the emerging relationships with sequence. Emphasis is placed on information from the high-resolution methods of X-ray crystallography and NMR, and their scope and current limitations are discussed. Such information, together with biological insights, will be important for the discovery of drugs targeting quadruplexes from particular genes.

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Metadata

Authors
Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K., & Neidle, S.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2006-09-29
Volume
34
Issue
19
Pages
5402-5415
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/gkl655
OpenAlex
W2171830519
Cited by
2,408
References
1
FWCI
26.03
Type
journal article
Language
en
Open access
gold

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Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K., & Neidle, S. (2006). Quadruplex DNA: sequence, topology and structure. Nucleic Acids Research. https://doi.org/10.1093/nar/gkl655

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