Evolution of enzymes and pathways for the biosynthesis of cofactors

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works

SCOP: A structural classification of proteins database for the investigation of sequences and structures

Murzin, A. G., Brenner, S. E., Hubbard, T., & Chothia, C. (1995) · Journal of Molecular Biology · doi:10.1016/s0022-2836(05)80134-2 · Cited by 6,412 · see citing works

Unravelling angiosperm genome evolution by phylogenetic analysis of chromosomal duplication events

Bowers, J., Chapman, B., Rong, J., & Paterson, A. H. (2003) · Nature · doi:10.1038/nature01521 · Cited by 1,595 · see citing works

Biochemistry of methanogenesis: a tribute to Marjory Stephenson:1998 Marjory Stephenson Prize Lecture

Thauer, R. K. (1998) · Microbiology · doi:10.1099/00221287-144-9-2377 · Cited by 1,112 · see citing works

ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION

Jensen, R. A. (1976) · Annual Review of Microbiology · doi:10.1146/annurev.mi.30.100176.002205 · Cited by 1,108 · see citing works

Ribonucleotide Reductases

Nordlund, P., & Reichard, P. A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142443 · Cited by 1,082 · see citing works

Many paths to methyltransfer: a chronicle of convergence

Schubert, H. L., Blumenthal, R. M., & Cheng, X. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00090-2 · Cited by 876 · see citing works

Tetrahydrobiopterin biosynthesis, regeneration and functions

Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/bj3470001 · Cited by 867 · see citing works

The emergence of life from iron monosulphide bubbles at a submarine hydrothermal redox and pH front

RUSSELL, M. J., & HALL, A. J. (1997) · Journal of the Geological Society · doi:10.1144/gsjgs.154.3.0377 · Cited by 822 · see citing works

The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes

Banerjee, R. V., & Ragsdale, S. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161828 · Cited by 795 · see citing works

Evolution of the first metabolic cycles.

Wächtershäuser, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.200 · Cited by 751 · see citing works

Iron‐sulphur clusters and the problem with oxygen

Imlay, J. A. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05028.x · Cited by 717 · see citing works

Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions

Huber, C., & Wächtershäuser, G. (1997) · Science · doi:10.1126/science.276.5310.245 · Cited by 714 · see citing works

On the Evolution of Biochemical Syntheses

Horowitz, N. H. (1945) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.31.6.153 · Cited by 610 · see citing works

COBALAMIN (COENZYME B 12 ): Synthesis and Biological Significance

Roth, J., Lawrence, J., & Bobik, T. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.137 · Cited by 566 · see citing works

Crystalline Vitamin B 12

Rickes, E. L., Brink, N. G., Koniuszy, F. R., Wood, T. R., & Folkers, K. (1948) · Science · doi:10.1126/science.107.2781.396 · Cited by 545 · see citing works

VITAMIN B12 DEFICIENCY AS A WORLDWIDE PROBLEM

Stabler, S. P., & Allen, R. H. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132440 · Cited by 539 · see citing works

TREATMENT OF PERNICIOUS ANEMIA BY A SPECIAL DIET

MINOT, G. R. (1926) · JAMA · doi:10.1001/jama.1926.02680070016005 · Cited by 504 · see citing works

Coenzymes as fossils of an earlier metabolic state

White, H. B. (1976) · Journal of Molecular Evolution · doi:10.1007/bf01732468 · Cited by 493 · see citing works

The biosynthesis of adenosylcobalamin (vitamin B12)

Warren, M. J., Raux, E., Schubert, H., & Escalante‐Semerena, J. C. (2002) · Natural Product Reports · doi:10.1039/b108967f · Cited by 484 · see citing works

Modern metabolism as a palimpsest of the RNA world

Benner, S. A., Ellington, A. D., & Tauer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7054 · Cited by 478 · see citing works

Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes

Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305837200 · Cited by 472 · see citing works

Vitamin B₁₂: Experiments Concerning the Origin of Its Molecular Structure

Eschenmoser, A. (1988) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198800051 · Cited by 374 · see citing works

Cell biology of molybdenum

Mendel, R. R., & Bittner, F. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.013 · Cited by 356 · see citing works

MOLYBDENUM COFACTOR BIOSYNTHESIS AND MOLYBDENUM ENZYMES

Schwarz, G., & Mendel, R. R. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105437 · Cited by 347 · see citing works

UBA 1: an essential yeast gene encoding ubiquitin‐activating enzyme.

McGrath, J. P., Jentsch, S., & Varshavsky, A. J. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07940.x · Cited by 286 · see citing works

Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium

Roth, J. R., Lawrence, J. G., Rubenfield, M., Kieffer-Higgins, S., & Church, G. M. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3303-3316.1993 · Cited by 277 · see citing works

Structure of Vitamin B12

Hodgkin, D. C., Kamper, J., Mackay, M. F., Pickworth, J., Trueblood, K. N., & WHITE, J. G. (1956) · Nature · doi:10.1038/178064a0 · Cited by 270 · see citing works

Purification of Anti-pernicious Anæmia Factors from Liver

Smith, E. L. (1948) · Nature · doi:10.1038/161638a0 · Cited by 242 · see citing works

On earlier states of the biochemical system

Yčas, M. (1974) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(74)80035-4 · Cited by 228 · see citing works

Recycled plastids: a ‘green movement’ in eukaryotic evolution

Archibald, J. M., & Keeling, P. J. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02777-4 · Cited by 227 · see citing works

S-Adenosylmethionine: A Wolf in Sheep's Clothing, or a Rich Man's Adenosylcobalamin?

Frey, P. A., & Magnússon, Ó. Þ. (2003) · Chemical Reviews · doi:10.1021/cr020422m · Cited by 222 · see citing works

On the Origin of Metabolic Pathways

Lazcano, A., & Miller, S. L. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00006565 · Cited by 219 · see citing works

Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum

Raux, E., Schubert, H., & Warren, M. J. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000670 · Cited by 211 · see citing works

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

Knighton, D. R., Kan, C., Howland, E. F., Janson, C. A., Hostomska, Z., Welsh, K. M., & Matthews, D. A. (1994) · Nature Structural Biology · doi:10.1038/nsb0394-186 · Cited by 197 · see citing works

Magnesium-protoporphyrin chelatase of Rhodobacter sphaeroides: reconstitution of activity by combining the products of the bchH, -I, and -D genes expressed in Escherichia coli.

Gibson, L. C. D., Willows, R. D., Kannangara, C. G., von WETTSTEIN, D., & Hunter, C. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1941 · Cited by 184 · see citing works

tRNAGlu as a cofactor in δ-aminolevulinate biosynthesis: steps that regulate chlorophyll synthesis

Gamini Kannangara, C., Gough, S. P., Bruyant, P., Kenneth Hoober, J., Kahn, A., & von Wettstein, D. (1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90071-0 · Cited by 172 · see citing works

Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase

Fodje, M. N., Hansson, A., HANSSON, M. G., Olsen, J. G., Gough, S. P., Willows, R. D., & Al‐Karadaghi, S. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4834 · Cited by 171 · see citing works

The relationship between structure and function for the sulfite reductases

Crane, B. R., & Getzoff, E. D. (1996) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(96)80003-0 · Cited by 157 · see citing works

Vitamin B12: How the Problem of Its Biosynthesis Was Solved

Blanche, F., Cameron, B., Crouzet, J., Debüssche, L., Thibaut, D., Vuilhorgne, M., Leeper, F. J., & Battersby, A. R. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199503831 · Cited by 142 · see citing works

Purification and characterization of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Pseudomonas denitrificans

Blanche, F., Debüssche, L., Thibaut, D., Crouzet, J., & Cameron, B. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.8.4222-4231.1989 · Cited by 139 · see citing works

A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A

Keefe, A. D., Newton, G. L., & Miller, S. L. (1995) · Nature · doi:10.1038/373683a0 · Cited by 136 · see citing works

Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans

Debüssche, L., Couder, M., Thibaut, D., Cameron, B., Crouzet, J., & Blanche, F. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.22.7445-7451.1992 · Cited by 136 · see citing works

Metabolites: a helping hand for pathway evolution?

Schmidt, S., Sunyaev, S. R., Peer Bork, B., & Dandekar, T. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00114-2 · Cited by 136 · see citing works

Tetrapyrrole assembly and modification into the ligands of biologically functional cofactors

Warren, M. J., & Scott, A. I. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90304-t · Cited by 135 · see citing works

Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock

Thompson, C. L., & Sancar, A. (2002) · Oncogene · doi:10.1038/sj.onc.1205958 · Cited by 129 · see citing works

Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli

Raux, E., Lanois, A., Levillayer, F., Warren, M. J., Brody, E. N., Rambach, A., & Thermes, C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.3.753-767.1996 · Cited by 129 · see citing works

Hydrogen-based carbon fixation in the earliest known photosynthetic organisms

Tice, M. M., & Lowe, D. R. (2005) · Geology · doi:10.1130/g22012.1 · Cited by 114 · see citing works

Elucidating biosynthetic pathways for vitamins and cofactors

Webb, M. E., Marquet, A., Mendel, R. R., Rébeillé, F., & Smith, A. G. (2007) · Natural Product Reports · doi:10.1039/b703105j · Cited by 113 · see citing works

BLOOD REGENERATION IN SEVERE ANEMIA

Robscheit-Robbins, F. S., & Whipple, G. H. (1925) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1925.72.3.408 · Cited by 108 · see citing works

Common Chelatase Design in the Branched Tetrapyrrole Pathways of Heme and Anaerobic Cobalamin Synthesis

Schubert, H., Raux, E., Wilson, K. S., & Warren, M. J. (1999) · Biochemistry · doi:10.1021/bi9906773 · Cited by 105 · see citing works

AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation

Nicolet, Y. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh728 · Cited by 105 · see citing works

Ribonucleotide Reductases: Divergent Evolution of an Ancient Enzyme

Torrents, E., Aloy, P., Gibert, I., & Rodrı́guez-Trelles, F. (2002) · Journal of Molecular Evolution · doi:10.1007/s00239-002-2311-7 · Cited by 104 · see citing works

A Story of Chelatase Evolution

Brindley, A. A., Raux, E., Leech, H. K., Schubert, H. L., & Warren, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302468200 · Cited by 102 · see citing works

Catalysing New Reactions during Evolution: Economy of Residues and Mechanism

Bartlett, G. J., Borkakoti, N., & Thornton, J. M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00734-4 · Cited by 100 · see citing works

Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing

Albert, A., Dhanaraj, V., Genschel, U., Khan, G., Ramjee, M. K., PULIDO, R., Sibanda, B. L., von Delft, F., Witty, M., Blundell, T. L., et al. (1998) · Nature Structural Biology · doi:10.1038/nsb0498-289 · Cited by 97 · see citing works

Biosynthesis of vitamin B12

Scott, A. I., Roessner, C. A., Stolowich, N. J., Spencer, J. B., Min, C., & Ozaki, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80306-f · Cited by 94 · see citing works

The Molybdenum Cofactor Biosynthetic Protein Cnx1 Complements Molybdate-Repairable Mutants, Transfers Molybdenum to the Metal Binding Pterin, and Is Associated with the Cytoskeleton

Schwarz, G., Schulze, J., Bittner, F., Eilers, T., Kuper, J., Bollmann, G., Nerlich, A., Brinkmann, H., & Mendel, R. R. (2000) · The Plant Cell · doi:10.1105/tpc.12.12.2455 · Cited by 90 · see citing works

Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans

Debüssche, L., Thibaut, D., Cameron, B., Crouzet, J., & Blanche, F. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.22.7430-7440.1993 · Cited by 87 · see citing works

A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis

Raux, E., Thermes, C., Heathcote, P., Rambach, A., & Warren, M. J. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.10.3202-3212.1997 · Cited by 82 · see citing works

How Nature Synthesizes Vitamin B12A Survey of the Last Four Billion Years

Scott, A. I. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199312233 · Cited by 82 · see citing works

Pathway evolution, structurally speaking

Rison, S. C. G., & Thornton, J. M. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00331-7 · Cited by 78 · see citing works

A primitive pathway of porphyrin biosynthesis and enzymology in Desulfovibrio vulgaris

Ishida, T., Yu, L., Akutsu, H., Ozawa, K., Kawanishi, S., Seto, A., Inubushi, T., & Sano, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4853 · Cited by 75 · see citing works

Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities

Mouillon, J., Ravanel, S., Douce, R., & Rébeillé, F. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630313 · Cited by 70 · see citing works

The Crystal Structure of E. coli Pantothenate Synthetase Confirms It as a Member of the Cytidylyltransferase Superfamily

von Delft, F., Lewendon, A., Dhanaraj, V., Blundell, T. L., Abell, C., & Smith, A. G. (2001) · Structure · doi:10.1016/s0969-2126(01)00604-9 · Cited by 69 · see citing works

The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase

Schubert, H., Wilson, K. S., Raux, E., Woodcock, S. C., & Warren, M. J. (1998) · Nature Structural Biology · doi:10.1038/846 · Cited by 69 · see citing works

On the origin of respiration: electron transport proteins from archaea to man

Schäfer, G., Purschke, W. G., & Schmidt, C. L. (1996) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1996.tb00235.x · Cited by 65 · see citing works

Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis

Vévodová, J., Graham, R. M., Raux, E., Schubert, H., Roper, D. I., Brindley, A. A., Scott, A. I., Roessner, C. A., Stamford, N. P. J., Stroupe, M. E., et al. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.09.020 · Cited by 63 · see citing works

The cradle chemistry of life: On the origin of natural products in a pyrite-pulled chemoautotrophic origin of life

Wächtershäuser, G. (1993) · Pure and Applied Chemistry · doi:10.1351/pac199365061343 · Cited by 60 · see citing works

Did primitive microorganisms use nonhem iron proteins in place of NAD/P?

Daniel, R. M., & Danson, M. J. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00160501 · Cited by 59 · see citing works

Identification and Characterization of a Novel Vitamin B12 (Cobalamin) Biosynthetic Enzyme (CobZ) from Rhodobacter capsulatus, Containing Flavin, Heme, and Fe-S Cofactors

McGoldrick, H. M., Roessner, C. A., Raux, E., Lawrence, A. D., McLean, K. J., Munro, A. W., Santabarbara, S., Rigby, S. E. J., Heathcote, P., Scott, A. I., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411884200 · Cited by 59 · see citing works

The ATPase Activity of the ChlI Subunit of Magnesium Chelatase and Formation of a Heptameric AAA+Ring

Reid, J. D., Siebert, C. A., Bullough, P. A., & Hunter, C. N. (2003) · Biochemistry · doi:10.1021/bi034082q · Cited by 57 · see citing works

Roles of vitamins B5, B8, B9, B12 and molybdenum cofactor at cellular and organismal levels

Rébeillé, F., Ravanel, S., Marquet, A., Mendel, R. R., Smith, A. G., & Warren, M. J. (2007) · Natural Product Reports · doi:10.1039/b703104c · Cited by 56 · see citing works

Characterization of the Cobaltochelatase CbiXL

Leech, H. K., Raux, E., McLean, K. J., Munro, A. W., Robinson, N. J., Borrelly, G. P. M., Malten, M., Jahn, D., Rigby, S. E. J., Heathcote, P., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306112200 · Cited by 56 · see citing works

Structure of E. coli Ketopantoate Hydroxymethyl Transferase Complexed with Ketopantoate and Mg2+, Solved by Locating 160 Selenomethionine Sites

von Delft, F., Tsuyoshi Inoue, A., Saldanha, S. A., Ottenhof, H. H., Schmitzberger, F., Birch, L. M., Dhanaraj, V., Witty, M., Smith, A. G., Blundell, T. L., et al. (2003) · Structure · doi:10.1016/s0969-2126(03)00158-8 · Cited by 55 · see citing works

Vitamin B12: Insights into Biosynthesis's Mount Improbable

Raux, E., Schubert, H., Roper, J. M., Wilson, K. S., & Warren, M. J. (1999) · Bioorganic Chemistry · doi:10.1006/bioo.1998.1125 · Cited by 54 · see citing works

Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism

Matak‐Vinković, D., Vinković, M., Saldanha, S. A., Ashurst, J. L., von Delft, F., Tsuyoshi Inoue, A., Miguel, R. N., Smith, A. G., Blundell, T. L., & Abell, C. (2001) · Biochemistry · doi:10.1021/bi011020w · Cited by 54 · see citing works

Parallels and Decisive Differences in Vitamin B12 Biosyntheses

Blanche, F., Thibaut, D., Debüssche, L., Hertle, R., Zipfel, F., & Müller, G. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199316511 · Cited by 52 · see citing works

Enzymic synthesis and structure of precorrin-3, a trimethyldipyrrocorphin intermediate in vitamin B12 biosynthesis

Warren, M. J., Roessner, C. A., Ozaki, S., Stolowich, N. J., Santander, P. J., & Scott, A. I. (1992) · Biochemistry · doi:10.1021/bi00117a043 · Cited by 52 · see citing works

How corrinoids are synthesized without oxygen: nature's first pathway to vitamin B12

Santander, P. J., Roessner, C. A., Stolowich, N. J., Holderman, M. T., & Scott, A. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90221-0 · Cited by 52 · see citing works

The FAD-Dependent Tricarballylate Dehydrogenase (TcuA) Enzyme of Salmonella enterica Converts Tricarballylate into cis -Aconitate

Lewis, J. A., & Escalante‐Semerena, J. C. (2006) · Journal of Bacteriology · doi:10.1128/jb.00514-06 · Cited by 51 · see citing works

Assay and purification of S-adenosyl-L-methionine:precorrin-2 methyltransferase from Pseudomonas denitrificans

Thibaut, D., Couder, M., Crouzet, J., Debüssche, L., Cameron, B., & Blanche, F. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.11.6245-6251.1990 · Cited by 49 · see citing works

The role of 4′‐phosphopantetheine in the biosynthesis of fatty acids, polyketides and peptides

Kleinkauf, H. (2000) · BioFactors · doi:10.1002/biof.5520110126 · Cited by 45 · see citing works

Current understanding of the function of magnesium chelatase

Reid, J. D., & Hunter, C. N. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300643 · Cited by 44 · see citing works

EM single particle analysis of the ATP-dependent BchI complex of magnesium chelatase: an AAA+ hexamer

Willows, R. D., Hansson, A., Birch, D., Al‐Karadaghi, S., & HANSSON, M. G. (2003) · Journal of Structural Biology · doi:10.1016/j.jsb.2003.11.019 · Cited by 44 · see citing works

Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus SB1003

Vlček, Č., Pačes, V., Maltsev, N., Pačes, J., Haselkorn, R., & Fonstein, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9384 · Cited by 43 · see citing works

Cytosolic Hydroxymethyldihydropterin Pyrophosphokinase/Dihydropteroate Synthase from Arabidopsis thaliana

Storozhenko, S., Navarrete, O. U., Ravanel, S., Brouwer, V. D., Chaerle, P., Zhang, G., Bastien, O., Lambert, W. E., Rébeillé, F., & Straeten, D. V. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701158200 · Cited by 42 · see citing works

Iron–sulfur proteins as initiators of radical chemistry

Marquet, A., Bui, B. T. S., Smith, A. G., & Warren, M. J. (2007) · Natural Product Reports · doi:10.1039/b703109m · Cited by 41 · see citing works

The Tricarballylate Utilization ( tcuRABC ) Genes of Salmonella enterica Serovar Typhimurium LT2

Lewis, J. A., Horswill, A. R., Schwem, B. E., & Escalante‐Semerena, J. C. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.6.1629-1637.2004 · Cited by 41 · see citing works

Timing of cobalt insertion in vitamin B12 biosynthesis

Mueller, G., Zipfel, F., Hlineny, K., Savvidis, E., Hertle, R., Traub‐Eberhard, U., Scott, A. I., Williams, H. J., & Stolowich, N. J. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00026a048 · Cited by 41 · see citing works

POSSIBLE ORIGIN FOR PORPHIN DERIVATIVES IN PREBIOTIC CHEMISTRY – A COMPUTATIONAL STUDY

Aylward, N., & Bofinger, N. (2005) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-005-2044-x · Cited by 35 · see citing works

The formation of chromophores through amino acid thermolysis and their possible role as prebiotic photoreceptors

Heinz, B., & Ried, W. (1981) · Biosystems · doi:10.1016/0303-2647(81)90019-8 · Cited by 31 · see citing works

Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway

Frank, S., Brindley, A. A., Deery, E. C., Heathcote, P., Lawrence, A. D., Leech, H. K., Pickersgill, R. W., & Warren, M. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330811 · Cited by 25 · see citing works

Ribonucleotide reduction and the possible role of cobalamin in evolution

Dickman, S. R. (1977) · Journal of Molecular Evolution · doi:10.1007/bf01764600 · Cited by 24 · see citing works

Structural insights into the evolution of the pantothenate-biosynthesis pathway

Lobley, C. M. C., Schmitzberger, F., Kilkenny, M. L., Whitney, H. M., Ottenhof, H. H., Chakauya, E., Webb, M. E., Birch, L. M., Tuck, K. L., Abell, C., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310563 · Cited by 19 · see citing works

Anaerobic protoporphyrin biosynthesis does not require incorporation of methyl groups from methionine

Bollivar, D. W., Elliott, T., & Beale, S. I. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.20.5778-5783.1995 · Cited by 12 · see citing works

Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B12 biosynthesis, and CbiL in complex with S‐adenosylhomocysteine − implications for the reaction mechanism

Wada, K., Harada, J., Yaeda, Y., Tamiaki, H., Oh‐oka, H., & Fukuyama, K. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05611.x · Cited by 11 · see citing works

Vitamin B12 as an allosteric cofactor; dual fluorescence, hysteresis, oscillations and the selection of corrin over porphyrinThe chemistry of vitamin B12. Part 32. For part 31, see ref. 1.

Chemaly, S. M., Jack, L. A., Yellowlees, L. J., Harper, P. L. S., Heeg, B., & Pratt, J. M. (2004) · Dalton Transactions · doi:10.1039/b403065f · Cited by 4 · see citing works

Biosynthesis of the modified tetrapyrroles—the pigments of life

Bryant, D. A., Hunter, C. N., & Warren, M. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.006194 · Cited by 303 · see citing works

Structural Insights into Radical Generation by the Radical SAM Superfamily

Vey, J. L., & Drennan, C. L. (2011) · Chemical Reviews · doi:10.1021/cr9002616 · Cited by 254 · see citing works

Chlorophylls, Symmetry, Chirality, and Photosynthesis

Senge, M. O., Ryan, A. A., Letchford, K. A., MacGowan, S. A., & Mielke, T. (2014) · Symmetry · doi:10.3390/sym6030781 · Cited by 253 · see citing works

Etiology of Potentially Primordial Biomolecular Structures: From Vitamin B12to the Nucleic Acids and an Inquiry into the Chemistry of Life’s Origin: A Retrospective

Eschenmoser, A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103672 · Cited by 192 · see citing works

Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima

Zhang, Y., Thiele, I., Weekes, D., Li, Z., Jaroszewski, L., Ginalski, K., Deacon, A. M., Wooley, J., Lesley, S. A., Wilson, I. A., et al. (2009) · Science · doi:10.1126/science.1174671 · Cited by 188 · see citing works

Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain

Holliday, G. L., Akiva, E., Meng, E. C., Brown, S. D., Calhoun, S., Pieper, U., Šali, A., Booker, S. J., & Babbitt, P. C. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.06.004 · Cited by 124 · see citing works

The origin and evolution of modern metabolism

Caetano‐Anollés, G., Yafremava, L. S., Gee, H., Caetano-Anollés, D., Kim, H. S., & Mittenthal, J. E. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.022 · Cited by 124 · see citing works

Molecular hijacking of siroheme for the synthesis of heme and <i>d</i> ₁ heme

Bali, S., Lawrence, A. D., Lobo, S. A., Saraiva, L. M., Golding, B. T., Palmer, D. J., Howard, M. J., Ferguson, S. J., & Warren, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108228108 · Cited by 120 · see citing works

Elucidating biosynthetic pathways for vitamins and cofactors

Webb, M. E., Marquet, A., Mendel, R. R., Rébeillé, F., & Smith, A. G. (2007) · Natural Product Reports · doi:10.1039/b703105j · Cited by 113 · see citing works

Functional diversity of organic molecule enzyme cofactors

Richter, M. (2013) · Natural Product Reports · doi:10.1039/c3np70045c · Cited by 109 · see citing works

Coenzymes and their role in the evolution of life

Kirschning, A. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.201914786 · Cited by 107 · see citing works

Out of fuzzy chemistry: from prebiotic chemistry to metabolic networks

Peretó, J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35054h · Cited by 96 · see citing works

The anaerobic biosynthesis of vitamin B12

Moore, S. J., & Warren, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120066 · Cited by 91 · see citing works

Peptides before and during the nucleotide world: an origins story emphasizing cooperation between proteins and nucleic acids

Fried, S. D., Fujishima, K., Makarov, M., Cherepashuk, I., & Hlouchová, K. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0641 · Cited by 77 · see citing works

Fundamental molecules of life are pigments which arose and co-evolved as a response to the thermodynamic imperative of dissipating the prevailing solar spectrum

Michaelian, K., & Simeonov, A. (2015) · Biogeosciences · doi:10.5194/bg-12-4913-2015 · Cited by 71 · see citing works

Widespread decay of vitamin-related pathways: coincidence or consequence?

Helliwell, K. E., Wheeler, G. L., & Smith, A. G. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.03.003 · Cited by 64 · see citing works

Total Synthesis, Structure, and Biological Activity of Adenosylrhodibalamin, the Non‐Natural Rhodium Homologue of Coenzyme B 12

Widner, F. J., Lawrence, A. D., Deery, E. C., Heldt, D., Frank, S., Gruber, K. F., Wurst, K., Warren, M. J., & Kräutler, B. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201603738 · Cited by 56 · see citing works

The convoluted history of haem biosynthesis

Koreny, L., Oborník, M., Horáková, E., Waller, R. F., & Lukeš, J. (2021) · Biological Reviews of The Cambridge Philosophical Society · doi:10.1111/brv.12794 · Cited by 43 · see citing works

Promiscuous and Adaptable Enzymes Fill “Holes” in the Tetrahydrofolate Pathway in Chlamydia Species

Adams, N. E., Thiaville, J. J., Proestos, J., Juárez-Vázquez, A. L., McCoy, A. J., Barona‐Gómez, F., Iwata‐Reuyl, D., de Crécy‐Lagard, V., & Maurelli, A. T. (2014) · mBio · doi:10.1128/mbio.01378-14 · Cited by 53 · see citing works

Recent advances in the biosynthesis of modified tetrapyrroles: the discovery of an alternative pathway for the formation of heme and heme d 1

Bali, S., Palmer, D. J., Schroeder, S., Ferguson, S. J., & Warren, M. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1563-x · Cited by 53 · see citing works

Ätiologie potentiell primordialer Biomolekül‐Strukturen: Vom Vitamin B12zu den Nukleinsäuren und der Frage nach der Chemie der Entstehung des Lebens – ein Rückblick

Eschenmoser, A. (2011) · Angewandte Chemie · doi:10.1002/ange.201103672 · Cited by 50 · see citing works

HemQ: an iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria

Dailey, H. A., & Gerdes, S. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.017 · Cited by 49 · see citing works

Allostery and the dynamic oligomerization of porphobilinogen synthase

Jaffe, E. K., & Lawrence, S. H. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.10.010 · Cited by 47 · see citing works

Metal and cofactor insertion

Mendel, R. R., Smith, A. G., Marquet, A., & Warren, M. J. (2007) · Natural Product Reports · doi:10.1039/b703112m · Cited by 43 · see citing works

Iron–sulfur proteins as initiators of radical chemistry

Marquet, A., Bui, B. T. S., Smith, A. G., & Warren, M. J. (2007) · Natural Product Reports · doi:10.1039/b703109m · Cited by 41 · see citing works

On the evolution of coenzyme biosynthesis

Kirschning, A. (2022) · Natural Product Reports · doi:10.1039/d2np00037g · Cited by 37 · see citing works

Analysis of differences in oxygen sensitivity of Fe–S clusters

Bruska, M. K., Stiebritz, M. T., & Reiher, M. (2013) · Dalton Transactions · doi:10.1039/c3dt50763g · Cited by 36 · see citing works

Origin of the Regioselective Reduction of Chlorins

Bruhn, T., & Brückner, C. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b00137 · Cited by 30 · see citing works

Pseudo-B 12 Joins the Cofactor Family

Taga, M. E., & Walker, G. C. (2007) · Journal of Bacteriology · doi:10.1128/jb.01892-07 · Cited by 29 · see citing works

Transcriptomics to evaluate the influence mechanisms of ethanol on the ester production of Wickerhamomyces anomalus with the induction of lactic acid

Cai, W., Wan, Y., Chen, Y., Fan, H., Li, M., Wu, S., Lin, P., Zeng, T., Luo, H., Huang, D., et al. (2024) · Food Microbiology · doi:10.1016/j.fm.2024.104556 · Cited by 27 · see citing works

Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes

Newton, M., Arcus, V. L., & Patrick, W. M. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0036 · Cited by 27 · see citing works

A tandem combinatorial model for the prebiogenesis of diverse tetrapyrrole macrocycles

Taniguchi, M., Soares, A. R. M., Chandrashaker, V., & Lindsey, J. S. (2012) · New Journal of Chemistry · doi:10.1039/c2nj21050a · Cited by 24 · see citing works

The use of mass spectrometry in a proteome‐centered multiomics study of human pituitary adenomas

Li, N., Desiderio, D. M., & Zhan, X. (2021) · Mass Spectrometry Reviews · doi:10.1002/mas.21710 · Cited by 24 · see citing works

The coenzyme/protein pair and the molecular evolution of life

Kirschning, A. (2020) · Natural Product Reports · doi:10.1039/d0np00037j · Cited by 21 · see citing works

Crystal Structure of Toxoplasma gondii Porphobilinogen Synthase

Jaffe, E. K., Shanmugam, D., Gardberg, A. S., Dieterich, S. H., Sankaran, B., Stewart, L. J., Myler, P. J., & Roos, D. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.226225 · Cited by 22 · see citing works

Methylations in vitamin B12 biosynthesis and catalysis

Mathur, Y., & Hazra, A. B. (2022) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2022.102490 · Cited by 21 · see citing works

Catalytic diversification upon metal scavenging in a prebiotic model for formation of tetrapyrrole macrocycles

Soares, A. R. M., Anderson, D. R., Chandrashaker, V., & Lindsey, J. S. (2013) · New Journal of Chemistry · doi:10.1039/c3nj00498h · Cited by 20 · see citing works

Primordial Oil Slick and the Formation of Hydrophobic Tetrapyrrole Macrocycles

Soares, A. R. M., Taniguchi, M., Chandrashaker, V., & Lindsey, J. S. (2012) · Astrobiology · doi:10.1089/ast.2012.0857 · Cited by 19 · see citing works

Auxin Signaling in Azospirillum brasilense : A Proteome Analysis

Spaepen, S., & Vanderleyden, J. (2015) · Biological nitrogen fixation · doi:10.1002/9781119053095.ch91 · Cited by 20 · see citing works

Is EC class predictable from reaction mechanism?

Nath, N., & Mitchell, J. B. O. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-60 · Cited by 19 · see citing works

Tracing the Early Emergence of Microbial Sulfur Metabolisms

Morrison, P. R., & Mojzsis, S. J. (2020) · Geomicrobiology Journal · doi:10.1080/01490451.2020.1812773 · Cited by 19 · see citing works

Evidence for corrin biosynthesis in the last universal common ancestor

Modjewski, L. D., Karavaeva, V., Mrnjavac, N., Knopp, M., Martin, W. F., & Sousa, F. L. (2025) · The FEBS Journal · doi:10.1111/febs.17367 · Cited by 15 · see citing works

Exploring the evolution of protein function in Archaea

Goncearenco, A., & Berezovsky, I. N. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-75 · Cited by 15 · see citing works

Binding of Reactive Oxygen Species at FeS Cubane Clusters

Bruska, M. K., Stiebritz, M. T., & Reiher, M. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201503008 · Cited by 14 · see citing works

Biosynthesis of Heme and Vitamin B12

Layer, G., Jahn, D., Deery, E. C., Lawrence, A. D., & Warren, M. J. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00144-1 · Cited by 13 · see citing works

The nickel-sirohydrochlorin formation mechanism of the ancestral class II chelatase CfbA in coenzyme F430 biosynthesis

Fujishiro, T., & Ogawa, S. Y. (2021) · Chemical Science · doi:10.1039/d0sc05439a · Cited by 11 · see citing works

Point Mutations (Q19P and N23K) Increase the Operational Solubility of a 2α-O-Benzoyltransferase that Conveys Various Acyl Groups from CoA to a Taxane Acceptor

Nawarathne, I. N., & Walker, K. D. (2010) · Journal of Natural Products · doi:10.1021/np900524d · Cited by 10 · see citing works

New Insights Into the Biosynthesis of Cobamides and Their Use

Costa, F. G., Deery, E. C., Warren, M. J., & Escalante‐Semerena, J. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14737-7 · Cited by 8 · see citing works

Totalsynthese, Struktur und biologische Aktivität von Adenosylrhodibalamin, dem unnatürlichen Rhodiumhomologen von Coenzym B12

Widner, F. J., Lawrence, A. D., Deery, E. C., Heldt, D., Frank, S., Gruber, K. F., Wurst, K., Warren, M. J., & Kräutler, B. (2016) · Angewandte Chemie · doi:10.1002/ange.201603738 · Cited by 7 · see citing works

Metabolic Engineering of Microbial Chassis Cells for d -Pantothenate Production: A Review

Zhu, F.-Y., Gu, Y., Cai, X., Zhou, J., Chen, Y., Wang, Y., Zhang, B., Liu, Z., & Zheng, Y. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00283 · Cited by 5 · see citing works

Coenzyme-Protein Interactions since Early LifePreprint

Sánchez-Rocha, A. C., Makarov, M., Pravda, L., Novotný, M., & Hlouchová, K. (2024) · eLife · doi:10.7554/elife.94174.1 · Cited by 5 · see citing works

Encasing the paramagnetic copper( ii )-ion by the ring-contracted corrin ligand of vitamin B 12

Kieninger, C., Wurst, K., Leitner, D., Peters, L. P., Dinu, D. F., Wiedemair, M., Zaretzke, M., Bröring, M., Hohloch, S., Liedl, K. R., et al. (2025) · Chemical Communications · doi:10.1039/d5cc02129d · Cited by 4 · see citing works

Coenzyme-protein interactions since early lifePreprint

Sánchez-Rocha, A. C., Makarov, M., Pravda, L., Novotný, M., & Hlouchová, K. (2024) · eLife · doi:10.1101/2023.10.28.563965 · Cited by 4 · see citing works

S -Adenosylmethionine: considerations on its role in the origin and evolution of life

Kirschning, A. (2026) · Natural Product Reports · doi:10.1039/d5np00079c · Cited by 4 · see citing works

Artificial intelligence in surgical practice: Truth beyond fancy covering

Ergenç, M. (2025) · Turkish Journal of Surgery · doi:10.47717/turkjsurg.2025.6797 · Cited by 2 · see citing works

Cloning, purification and preliminary crystallographic analysis of cobalamin methyltransferases fromRhodobacter capsulatus

Seyedarabi, A., Hutchison, T., To, T. T., Deery, E. C., Brindley, A. A., Warren, M. J., & Pickersgill, R. W. (2010) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309110042910 · Cited by 2 · see citing works

Coenzyme und ihre Rolle in der Evolution des Lebens

Kirschning, A. (2020) · Angewandte Chemie · doi:10.1002/ange.201914786 · Cited by 2 · see citing works

Cofactors

Haase, I., Fischer, M. J., Bacher, A., Eisenreich, W., & Rohdich, F. (2012) · Wiley eBooks · doi:10.1002/9781118391815.ch10 · Cited by 2 · see citing works

Coenzyme-Protein Interactions since Early LifePreprint

Sánchez-Rocha, A. C., Makarov, M., Pravda, L., Novotný, M., & Hlouchová, K. (2024) · eLife · doi:10.7554/elife.94174.2 · Cited by 2 · see citing works

Methanogenesis and metal leaching on anaerobic decomposition of graptolite argillite

Menert, A., Korb, T., Orupõld, K., Teemusk, A., Sepp, H., Mander, Ü., Ilmjärv, T., Truu, J., Paiste, P., Kirsimäe, K., et al. (2023) · Environmental Technology & Innovation · doi:10.1016/j.eti.2023.103139 · Cited by 1 · see citing works

From Ionizing Radiation to Photosynthesis

Melkozernov, A. N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1148-6_13 · Cited by 1 · see citing works

Synthetic Biology in Metabolic Engineering: From Complex Biochemical Pathways to Compartmentalized Metabolic Processes - a Vitamin Connection

Deery, E. C., Frank, S., Lawrence, A. D., Moore, S. J., Schroeder, S., & Warren, M. J. (2014) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.20120075

ChemInform Abstract: Evolution of Enzymes and Pathways for the Biosynthesis of Cofactors

Holliday, G. L., Thornton, J. M., Marquet, A., Smith, A. G., Rébeillé, F., Mendel, R. R., Schubert, H., Lawrence, A. D., & Warren, M. J. (2007) · ChemInform · doi:10.1002/chin.200801265

A Bioinformatics Approach to Identifying Radical SAM (S-Adenosyl-L-Methionine) Enzymes

Gagliano, E. (2020) · VTechWorks (Virginia Tech)

Cofactors and Coenzymes | Biosynthesis of Vitamin B12 (Cobalamin) and Related Corrinoids

Deery, E. C., Ikeru, P., & Warren, M. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00339-x

Cofactor Biosynthesis

Haase, I., Fischer, M. J., Bacher, A., Eisenreich, W., & Rohdich, F. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb094

Insight into key microbes drive the fatty acid β-oxidation pathway and longevity regulation pathway-worm: Unraveling earthworm detoxification mechanisms and potential remediation strategies under microplastic‑cadmium co-exposure

Ning, Y., Bao, J., Xue, J., Qu, B., Gong, J., Wang, C., & Zhou, D. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180096

On the evolution of coenzyme biosynthesis

Kirschning, A. (2022) · Natural Product Reports · doi:10.1039/d2np00037g · Cited by 37 · see citing works

Elucidating biosynthetic pathways for vitamins and cofactors

Webb, M. E., Marquet, A., Mendel, R. R., Rébeillé, F., & Smith, A. G. (2007) · Natural Product Reports · doi:10.1039/b703105j · Cited by 113 · see citing works

On the levels of enzymatic substrate specificity: Implications for the early evolution of metabolic pathways

Lazcano, A., Villagómez, E. D., Mills, T., & Oro, J. A. (1995) · Advances in Space Research · doi:10.1016/s0273-1177(99)80106-9 · Cited by 30 · see citing works

Cofactor Biosynthesis

Haase, I., Fischer, M. J., Bacher, A., Eisenreich, W., & Rohdich, F. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb094

Metabolites: a helping hand for pathway evolution? Trends Biochem

Schmidt, S., Sunyaev, S. R., Peer Bork, B., & Thomas, D. (2003)