The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Molecular hydrogels of therapeutic agents
Abstract
This tutorial review aims to introduce a new kind of biomaterials-molecular hydrogels of therapeutic agents. Based on the molecular self-assembly in water, it is possible to transform therapeutic agents into analogues that form hydrogels without compromising their pharmacological efficacy. This transformation can be beneficial in three aspects: (i) the therapeutic agents become "self-deliverable" in the form of hydrogels; (ii) the self-assembly of hydrogelators of drugs might confer new and useful properties such as multivalency or high local densities; (iii) the exploration of molecular hydrogels of drugs may ultimately lead to bioactive molecules that have dual or multiple roles. By summarizing the reports on the molecular hydrogels made from clinical used drugs or other bioactive molecules, this article presents representative molecular hydrogels of therapeutics and outlines the promises and challenges for developing this new class of biomaterials.
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Cites
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Supramolecular gel chemistry: developments over the last decade
Steed, J. W. (2011) · Chem. Commun. · doi:10.1039/c0cc03293j · Cited by 640
Tao, K., Levin, A., Adler-Abramovich, L., & Gazit, E. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00889a · Cited by 482
Stimuli-responsive gels as reaction vessels and reusable catalysts
Díaz Díaz, D., Kühbeck, D., & Koopmans, R. J. (2011) · Chem. Soc. Rev. · doi:10.1039/c005401c · Cited by 441
Supramolecular hydrogels: synthesis, properties and their biomedical applications
Dong, R., Pang, Y., Su, Y., & Zhu, X. (2015) · Biomaterials Science · doi:10.1039/c4bm00448e · Cited by 302
Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop
Xu, T., Wang, J., Zhao, S., Chen, D., Zhang, H., Fang, Y., Kong, N., Zhou, Z., Li, W., & Wang, H. (2023) · Nature Communications · doi:10.1038/s41467-023-39648-2 · Cited by 132
Metadata
- Authors
- Zhao, F., Ma, M. L., & Xu, B.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 38
- Issue
- 4
- Pages
- 883
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W1969268706
- Cited by
- 493
- References
- 32
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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