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FLASH: A rapid method for prototyping paper-based microfluidic devices
Open accessAbstract
This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of microfluidic devices in paper. Paper-based microfluidic devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 microm in width and 70 microm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based microfluidic devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based microfluidic devices in regions where the technological support for conventional photolithography is not available.
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Cited by
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995
Flexographically Printed Fluidic Structures in Paper
Olkkonen, J., Lehtinen, K., & Erho, T. (2010) · Analytical Chemistry · doi:10.1021/ac1027066 · Cited by 369
Point of care testing: The impact of nanotechnology
Syedmoradi, L., Daneshpour, M., Alvandipour, M., Gomez, F. A., Hajghassem, H., & Omidfar, K. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.084 · Cited by 367
Nano/Microfluidics for diagnosis of infectious diseases in developing countries
Lee, W. G., Kim, Y.-G., Chung, B. G., Demirci, U., & Khademhosseini, A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.016 · Cited by 357
Metadata
- Authors
- Martinez, A. W., Phillips, S. T., Wiley, B. J., Gupta, M., & Whitesides, G. M.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 8
- Issue
- 12
- Pages
- 2146
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2061120454
- Cited by
- 695
- References
- 0
- FWCI
- 20.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Martinez, A. W., Phillips, S. T., Wiley, B. J., Gupta, M., & Whitesides, G. M. (2008). FLASH: A rapid method for prototyping paper-based microfluidic devices. Lab on a Chip. https://doi.org/10.1039/b811135a
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